Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)-
- CAS No.
- 1225278-64-7
- Chemical Name:
- Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)-
- Synonyms
- Oliceridine Impurity 20;1,3-Dioxane-5,5-dimethanol,2-(6-methoxyphenyl)-;2-chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine;Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)-
- CBNumber:
- CB62666738
- Molecular Formula:
- C11H5ClF2N2O3
- Molecular Weight:
- 286.62
- MDL Number:
- MFCD19187858
- MOL File:
- 1225278-64-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)- | CS-M2313 | 250mg | $154 |
| 2-Chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine | 3169AH | 100mg | $189 |
| 2-Chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine | 3169AH | 250mg | $273 |
| Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)- | CS-M2313 | 1g | $330 |
| 2-Chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine | 3169AH | 1g | $601 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-M2313 | Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)- | 1225278-64-7 | 250mg | $154 | 2021-12-16 | Buy |
| AK Scientific | 3169AH | 2-Chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine | 1225278-64-7 | 100mg | $189 | 2021-12-16 | Buy |
| AK Scientific | 3169AH | 2-Chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine | 1225278-64-7 | 250mg | $273 | 2021-12-16 | Buy |
| ChemScene | CS-M2313 | Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)- | 1225278-64-7 | 1g | $330 | 2021-12-16 | Buy |
| AK Scientific | 3169AH | 2-Chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine | 1225278-64-7 | 1g | $601 | 2021-12-16 | Buy |
Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)- Chemical Properties,Uses,Production
Synthesis
17368-12-6
2105-61-5
1225278-64-7
Sodium hydride (136 mg, 3.4 mmol, 60% mineral oil dispersion) was added batchwise to an anhydrous N,N-dimethylformamide (DMF, 38 mL) solution of 2-chloro-4-hydroxypyridine (2 g, 15.4 mmol) under argon protection. The reaction mixture was stirred at 0 °C for 1 hour. Subsequently, a solution of 2,4,5-trifluoronitrobenzene (626 mg, 3.1 mmol) in anhydrous DMF (7.6 mL) was added dropwise and the reaction system was warmed up to 90 °C under argon protection with continuous stirring for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and stirring was continued overnight. The solvent was removed by distillation under reduced pressure and the crude product was partitioned with 50 mL of water and 50 mL of ethyl acetate (EtOAc). The aqueous phase was extracted with ethyl acetate (3 x 50 mL) and the combined organic phases were washed with saturated saline and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the target compound 2-chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine (3.57 g, 81% yield) was purified by silica gel column chromatography (eluent: hexane/ethyl acetate gradient). The product was characterized by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (ESI): 1H NMR δ 8.43-8.33 (m, 2H), 7.85-7.79 (m, 1H), 7.33 (d, 1H), 7.20-7.18 (m, 1H); MS (ESI) m/z: 287.0 [M+H]+.
References
[1] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 73-74
[2] Patent: WO2011/137342, 2011, A1. Location in patent: Page/Page column 31
[3] Patent: WO2013/78295, 2013, A2. Location in patent: Paragraph 00171
[4] Patent: WO2014/145004, 2014, A1. Location in patent: Paragraph 0100
[5] Patent: US2014/315917, 2014, A1. Location in patent: Paragraph 0312
Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)- Preparation Products And Raw materials
Raw materials
Preparation Products
Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
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| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
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| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| DebyeTec.com Inc. | 18-086626237 18086626237 | 2693528373@qq.com | China | 2973 | 56 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
