XMU-MP-1
- CAS No.
- 2061980-01-4
- Chemical Name:
- XMU-MP-1
- Synonyms
- 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide;CS-2590;XMU-MP-1;XUM-MP- 1;PubChem ID: 121499143;XMU MP 1,Inhibitor,Hippo (MST),inhibit,XMUMP1;4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide;Benzenesulfonamide, 4-[(6,10-dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]-
- CBNumber:
- CB63122127
- Molecular Formula:
- C17H16N6O3S2
- Molecular Weight:
- 416.48
- MDL Number:
- MFCD30377214
- MOL File:
- 2061980-01-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
XMU-MP-1 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2233 | XMU-MP-1 hydrochloride ≥98% (HPLC) | 2061980-01-4 | 5mg | $206 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2233 | XMU-MP-1 hydrochloride ≥98% (HPLC) | 2061980-01-4 | 25mg | $328.8 | 2024-03-01 | Buy |
| Cayman Chemical | 22083 | XMU-MP-1 ≥98% | 2061980-01-4 | 1mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 22083 | XMU-MP-1 ≥98% | 2061980-01-4 | 5mg | $175 | 2024-03-01 | Buy |
| Cayman Chemical | 22083 | XMU-MP-1 ≥98% | 2061980-01-4 | 10mg | $308 | 2024-03-01 | Buy |
XMU-MP-1 Chemical Properties,Uses,Production
Description
XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2 (IC50s = 71.1 and 38.1 nM, respectively). It is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 μM. XMU-MP-1 inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner. It also prevents cell death induced by overexpression of MST2. XMU-MP-1 (1 mg/kg) enhances liver regeneration in mice post partial hepatectomy and reduces liver fibrosis in a mouse model of chronic liver injury.
Uses
XMU-?MP-?1 an MST1/2 inhibitor.
storage
Store at -20°C
References
1. fuqin fan, zhixiang he, lu-lu kong, et al. pharmacological targeting of kinases mst1 and mst2 augments tissue repair and regeneration. science translational medicine 17 aug 2016: vol. 8, issue 352, pp. 352ra108.
XMU-MP-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Luofa Biochemical Technology Co., Ltd. | 021-51111890 15317326293 | sales@molnova.com | China | 4196 | 58 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2031 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |