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Diosmin

Pharmacological Effects Side Effects Taboos Attentions Uses Pregnant Women and Nursing Mothers Drug Use
Diosmin
Diosmin structure
CAS No.
520-27-4
Chemical Name:
Diosmin
Synonyms
Dioven;Daflon;DIOSMIN;Diosven;Diosmil;DIOSIMIN;Diovenor;BAROSMIN;DIOSMINE;Venosmine
CBNumber:
CB6443258
Molecular Formula:
C28H32O15
Formula Weight:
608.54
MOL File:
520-27-4.mol

Diosmin Properties

Melting point:
277-278°C
storage temp. 
2-8°C
solubility 
Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides.
form 
neat
Water Solubility 
Soluble in DMSO (50 mg/ml), water (122 mg/ml at 25°C), and ethanol (<1 mg/ml at 25°C).
λmax
345nm(EtOH)(lit.)
Merck 
14,3297
CAS DataBase Reference
520-27-4(CAS DataBase Reference)

SAFETY

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-36/37-24/25
WGK Germany  3

Diosmin price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 61386 Diosmin analytical standard 520-27-4 50mg $241 2018-11-20 Buy
Sigma-Aldrich 1213318 Diosmin United States Pharmacopeia (USP) Reference Standard 520-27-4 300mg $357.7 2018-11-20 Buy
TCI Chemical D3908 Diosmin >85.0%(HPLC) 520-27-4 5g $32 2018-11-22 Buy
TCI Chemical D3908 Diosmin >85.0%(HPLC) 520-27-4 25g $105 2018-11-22 Buy
Alfa Aesar J62073 Diosmin 520-27-4 5g $35.2 2018-11-13 Buy

Diosmin Chemical Properties,Uses,Production

Pharmacological Effects

Diosmin is also called Alvenor. It is a kind of drug for the treatment of hemorrhoid symptoms related to acute episodes, can also be used in the treatment of symptoms associated with venous lymphatic insufficiency (leg heavy, pain, morning acid swells discomfort).
The effects of diosmin are as below:
1, Has specific affinity to the venous system, enhance the tension system without affecting the artery of vein;
2, To the microcirculation system, decrease the blood viscosity, improve the velocity of reducing silt up;
3, Contract the lymphatic system, which can enhance lymphatic and lymph drainage speed, speed up the return relieve edema.
4, Commercially available diosmin uses micronization technology, increase the contact area after using medicine, absorb more and higher bioavailability. Suitable for all kinds of hemorrhoids and acute hemorrhoids, also can be used for the treatment of chronic venous insufficiency, such as varicose veins, leg ulcers, etc.
This information is edited by ChemicalBook Xiao Nan.

Side Effects

1, May appear nausea, vomiting, abdominal pain, dyspepsia, diarrhea, insomnia, dizziness, headache, drowsiness, anxiety and other adverse reactions.
2, There may be a few of minor gastrointestinal reactions and adverse reactions such as plant nerve function disorder, but generally mild and don't have to stop the drug.
3, Pregnant women and nursing mothers with hemorrhoids are safe to use this product.

Taboos

People who allergy to any ingredients in this product are prohibited.

Attentions

Hemorrhoid acute episodes: treatment with this drug can't replace any other special treatments needed for handling anus diseases. This treatment must be short. If symptoms cannot eliminate quickly, anorectal epidemiology check and review should be needed.
This product contains flavonoids which is the effective composition of glycosides in plants. Effective flavonoid content for each piece of diosmin is 450 mg, 50 mg of hesperidin, the total flavonoid glycosides composition (also called Daflon) is 500 mg. General flavonoids have certain biological activity, but low toxicity and rare allergic reactions, if any allergies, stop the drug.

Uses

Used in food, medicine, health products, etc
Action mechanism:
1.Enhance the vein tension, even not exceptional under high temperature condition. It has a stronger effect causing the constriction of vein than other drugs such as rutin, still can enhance the tension of the vein when the body was acidosis. Diosmin has specific affinity for vein without affecting the arterial system.
2. Improve microcirculation. Diosmin can obviously reduce the white blood cells and vascular endothelial cell adhesion, migration, disintegrating the release of inflammatory substances, such as histamine, slow excitation peptide, complement, leukotriene, prostaglandins, and too many free radicals, reducing the permeability of capillaries and enhance its tension. Diosmin can lower blood viscosity, enhance the function of red blood cell velocity, thus reduce the microcirculation clogged.
3. Promote lymphatic circumfluence. Diosmin can increase the speed of lymphatic drainage.

Pregnant Women and Nursing Mothers Drug Use

Pregnancy women use: animal experiments did not show any teratogenic effects. So far, still no harmful reports to human.
Delivery: there is no detailed research data.
Nursing mothers use: although there is no information on drug secreted with breast milk, but treatment is not recommended during breastfeeding.

Chemical Properties

Brown powder

Uses

vascular protectant

Uses

Naturally occurring flavonic glycoside; rhamnoglycoside of Diosmetin. Capillary protectant

Definition

ChEBI: A disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.

Diosmin Preparation Products And Raw materials

Raw materials

Preparation Products


Diosmin Suppliers

Global( 335)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21984 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 541 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1730 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2236 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58

View Lastest Price from Diosmin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-16 Diosmin
520-27-4
US $8.00 / kg 1kg 98% 10MT career henan chemical co
2018-12-15 Diosmin
520-27-4
US $1.00 / kg 1kg 99% Customized career henan chemical co

Diosmin Spectrum


520-27-4(Diosmin)Related Search:


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  • DIOSMETIN-7-RUTINOSIDE
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  • BAROSMIN
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  • DIOSIMIN
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  • DIOSMIN WITH HPLC
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  • Flebosten
  • 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-
  • Diosmin, >=95%
  • Diosmin+Hesperidin 90:10
  • 3',5,7-TRIHYDROXY-4'-METHOXYFLAVONE 7-RUTINOSIDE
  • 3,5,7-TRIHYDROXY-4-METHOXYFLAVONE 7-RUTINOSIDE
  • 7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(3-hydroxy-4-methoxyphenyl)-5-hydroxy-4H-1-benzopyran-4-one
  • 7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
  • Hesperedin
  • Diosmin (300 mg)
  • Barosmin 3',5,7-Trihydroxy-4'-methoxyflavone 7-Rutinoside
  • DiosMin (3',5,7-Trihydroxy-4'-Methoxyflavone 7-rutinoside)
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  • Diosmine EP4
  • DIOSMINE
  • Buchu resin
  • Daflon
  • Diosmil
  • 520-27-4
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  • C28H32O15
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  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
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