ChemicalBook
Chinese English Japanese Germany Korea

디오스민

디오스민
디오스민 구조식 이미지
카스 번호:
520-27-4
한글명:
디오스민
동의어(한글):
디오스민;다이오스민
상품명:
Diosmin
동의어(영문):
SiF6;Dioven;Daflon;DIOSMIN;Diosven;Diosmil;DIOSIMIN;Diovenor;BAROSMIN;DIOSMINE
CBNumber:
CB6443258
분자식:
C28H32O15
포뮬러 무게:
608.54
MOL 파일:
520-27-4.mol

디오스민 속성

녹는점
277-278°C
끓는 점
926.8±65.0 °C(Predicted)
밀도
1.68±0.1 g/cm3(Predicted)
저장 조건
Sealed in dry,2-8°C
용해도
Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides.
물리적 상태
neat
산도 계수 (pKa)
6.10±0.40(Predicted)
수용성
Soluble in DMSO (50 mg/ml), water (122 mg/ml at 25°C), and ethanol (<1 mg/ml at 25°C).
최대 파장(λmax)
345nm(EtOH)(lit.)
Merck
14,3297
InChIKey
GZSOSUNBTXMUFQ-YFAPSIMESA-N
CAS 데이터베이스
520-27-4(CAS DataBase Reference)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36-36/37-24/25
WGK 독일 3
HS 번호 29381000
기존화학 물질 KE-34297

디오스민 C화학적 특성, 용도, 생산

개요

Diosmin was separated from the root of Scrophularia nodosa L.玄参 in 1925. The root of Scrophularia nodosa L. 玄参has the function of nourishing, reducing fever, relieving internal heat, and detoxicating. It was firstly recorded in the Shen Nong’s Classic of Materia Medica, as a class of middle-grade drug and is currently recorded in the Ch.P 2015, Volume I. The natural resource was abundant in China, mainly provided from Zhejiang, Sichuan, Hubei, Anhui, and Jiangsu provinces. In the clinical practice, Scrophularia nodosa L.玄参 was employed to eliminate pathogenic heat from the blood. In the clinical indication, it was mainly applied to treat fever, polydipsia, maculitis, gingivitis, amygdalitis, laryngopharyngitis, acute lymphadenitis, etc. It also has the biological function of antiplatelet aggregation and antitumor. The chemical components include iridoids, phenylpropanoid glycoside, flavonoids, and fatty acids.

화학적 성질

Brown powder

물리적 성질

Appearance: Grayish yellow or light yellow hygroscopic powder. Solubility: Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides. Melting point: 277–278?°C.

Originator

Diosmil,Bellon,France,1971

역사

Diosmin was firstly introduced as a medicine in 1969. It was launched in France in 1987 with the product name “Alvenor.” As the protecting agent for blood vessel and therapeutic agent for chronic venous disease, diosmin has been used for over 30?years in Europe
Diosmin is a typical flavonoid. It could be prepared from natural resources or semisynthesized from the natural product hesperidin by dehydrogenation reaction.

용도

vascular protectant

용도

Naturally occurring flavonic glycoside; rhamnoglycoside of Diosmetin. Capillary protectant

정의

ChEBI: A disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.

Indications

The clinical indications of diosmin are those symptoms related to venous-lymphatic dysfunction such as leg heaviness, pains, soreness, and swelling in the morning. Besides, the symptoms related to acute hemorrhoids could also be treated with diosmin.

Manufacturing Process

A mixture of 72 g hesperidin, 288 ml acetic anhydride and 300 ml glacial acetic acid were boiled in reflux with 15 ml pyridine as the catalyst for 144 hours until during the control of the reaction the band disappeared at a wave length between 264 to 280 nm, and a new maximum appeared at 330 nm. Thereafter in a rotation evaporator the reaction mixture was concentrated by evaporation under vacuum conditions.
The residue was absorbed in 1,200 ml ethyl acetate, admixed with 20 ml ethanol and boiled for one hour under reflux action. The solution was filtered and compressed to dryness. The residue was dried in a vacuum drying cabinet. The yield amounted to 107.5 g.
35.8 g thereof were then dissolved in 280 ml glacial acetic acid and
ominated with a solution of 6.05 g
omine in 30 ml glacial acetic acid. Thereafter the mixture compressed to dryness by means of the rotation evaporator, there being obtained a residue of 41.8 g. Such was dissolved in 150 ml methanol, admixed with a solution of 36 g sodium hydroxide in 180 ml water and stirred for one hour at 50°C.
The diosmin was precipitated out by adding 120 ml glacial acetic acid and stirring at 70°C for 30 minutes. The precipitate was filtrated in a suction filter or strainer, washed with methanol, water and again methanol and dried at 60°C in the drying cabinet. Raw yield: 17.0 g corresponding to 71% yield.
omine content 0.51%.
10 g of the thus-obtained diosmin was dissolved in a solution of 24 g sodium hydroxide in 120 ml water, admixed with 100 ml methanol and 100 ml pyridine and stirred for one hour at 50°C. The diosmin was precipitated by the addition of 100 ml glacial acetic acid and stirred for 30 minutes at 70°C, filtered and washed with methanol and water and again methanol.
After drying at 60°C there was obtained a pure yield of 9.2 g diosmin (65% based upon the employed hesperidin) having a
omine content of 0.07%.

Therapeutic Function

Bioflavonoid

Pharmacology

Diosmin is a micronized, purified, flavonoid-structure drug. It is helpful for lymphatic return and stimulating microcirculation, treating hemorrhoids and venous dysfunction by increasing the venous tension.
1. Increasing the venous tension. Diosmin could strengthen the tensile force of the venous wall even under high temperature. Diosmin’s action in venous constriction is stronger than other drugs like rutin. Even under the acidic toxicity in the body, it could still raise the venous tension. Diosmin has special affinity to the venous other than the arterial system.
2. Improving the microcirculation. Diosmin could effectively reduce adhesion and migration of leukocyte and vascular endothelial cells. It could also release inflammatory substances such as histamine, bradykinin, alexin, leukotriene, prostaglandin, and surplus free radicals. Hence, the penetration of capillary blood vessel was reduced, and the tension was enhanced. Besides, diosmin could decrease blood viscosity, accelerate erythrocyte flow rate, and finally reduce the chances of microcirculatory stasis
3. Stimulating the lymphatic return. Diosmin could effectively increase the speed of lymphatic drainage and the lymphatic contraction, accelerating the circumfluence of interstitial fluid, improving lymphatic return, and relieving edema.

Clinical Use

Diosmin was mainly used to treat diseases like chronic venous dysfunction, haemorrhoids, lymphedema, phlebeurysm, etc.

디오스민 준비 용품 및 원자재

원자재

준비 용품


디오스민 공급 업체

글로벌( 473)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1009 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58

Copyright 2019 © ChemicalBook. All rights reserved