ChemicalBook >> CAS DataBase List >>Paeonol


Chemical Name:
Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-;PEONOL;Paeonal;1-(2-HYDROXY-4-METHOXYPHENYL)ETHANONE;1-(2-HYDROXY-4-METHOXYPHENYL)ETHAN-1-ONE;Paeonol std.;2-Hydroxy-4-methoxy;Paeol;PAEONOL;Paeonolum
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Modify Date:2022-08-15 17:37:01

Paeonol Properties

Melting point 48-50 °C(lit.)
Boiling point 154 °C / 20mmHg
Density 1.3102
refractive index 1.5452 (estimate)
Flash point >230 °F
storage temp. 2-8°C
solubility Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
pka 9.79±0.10(Predicted)
form Crystalline Powder
color White to beige
BRN 1282794
CAS DataBase Reference 552-41-0(CAS DataBase Reference)
EWG's Food Scores 1
NIST Chemistry Reference Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-(552-41-0)


Risk and Safety Statements

Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P264-P280-P302+P352+P312-P304+P340+P312-P337+P313
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  26-28-36/37/39-45
WGK Germany  3
RTECS  RT1215000
Hazard Note  Irritant
HS Code  29145090
Toxicity LD50 orl-mus: 3430 mg/kg YKKZAJ 89,1205,69
NFPA 704
2 0

Paeonol price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H35803 2′-Hydroxy-4′-methoxyacetophenone 99% 552-41-0 1g $31.2 2022-05-15 Buy
Sigma-Aldrich H35803 2′-Hydroxy-4′-methoxyacetophenone 99% 552-41-0 10g $88.3 2022-05-15 Buy
TCI Chemical H0789 2'-Hydroxy-4'-methoxyacetophenone >98.0%(GC) 552-41-0 5g $19 2022-04-27 Buy
TCI Chemical H0789 2'-Hydroxy-4'-methoxyacetophenone >98.0%(GC) 552-41-0 25g $53 2022-04-27 Buy
Alfa Aesar B22173 2'-Hydroxy-4'-methoxyacetophenone, 99% 552-41-0 25g $151 2021-12-16 Buy
Product number Packaging Price Buy
H35803 1g $31.2 Buy
H35803 10g $88.3 Buy
H0789 5g $19 Buy
H0789 25g $53 Buy
B22173 25g $151 Buy

Paeonol Chemical Properties,Uses,Production


Paeonol is the main active ingredient of the cortex of thePaeonol raw materials with high purity can be derived from plant extracts by chemical synthesis. The commonly used extraction methods of paeonol include boiling method, alcohol extraction, steam distillation, and CO2 supercritical fluid extraction . But due to the limitation of plant resources and the lower content of paeonol in the natural plants, there are many separation and purification difficulties existed in the extraction methods. The chemical synthesis process is relatively easy, and the final product usually can be obtained through two- to three-step reaction and separation process . Ranunculaceae plants including Paeonia suffruticosa Andr. (Moutan cortex, Mudanpi) and Rhododendron plant Cynanchum paniculatum (Bge.) Kitag. (Cynanchi paniculati radix et rhizome, Xuchangqing). Moutan cortex and Xuchangqing are commonly used as traditional Chinese medicine. Moutan cortex has the effects on clearing heat, cooling blood, activating blood, resolving stasis, and retreating heat; Xuchangqing also has many effects, such as dispelling wind, relieving pain and itching, and so on.

Chemical Properties

white to beige crystalline powder

Physical properties

Appearance: white or light yellow, shining, needlelike crystals. Solubility: freely soluble in ethanol and methanol; soluble in diethyl ether, acetone, benzene, chloroform, and carbon disulfide; slightly soluble in water; and soluble in hot water, practically insoluble in cold water, and volatilizing in water vapor. Melting point: 48–51?°C.


As the main active ingredient of Moutan cortex and Xuchangqing, paeonol has been used in clinical practice since ancient times. Paeonol was first isolated from Moutan cortex by Japanese scholar Changjing Changyi in 1884 . This clinical observation was proceeded at more than 10 medical units in Shanghai and other places and lasted more than 1 year since 1971. Paeonol injection was the earliest recorded in the Chinese pharmacopoeia 1977 edition; it is the main formulation until now. But because of the poor water solubility of paeonol, it is necessary to improve its solubility to be used as injection. Ten times amount of Tween compared to paeonol was used in the injection to increase the dissolution. In the 1970s, paeonol was made into oil solution for intramuscular injection. But these are with security risks and the use of inconvenience and other shortcomings. Pharmacist obtained paeonol sodium sulfonate by sulfonated paeonol, so the problem of water solubility had been resolved, and the injection of paeonol sodium sulfonate also came into being . In 2003, the quality standard of paeonol sodium sulfonate was also promoted from the local standard to the national standard. The dosage form of paeonol for skin is mainly ointment.


An anti-inflammatory & anti-lipid peroxidation agent


antibacterial, antimutagen, anti-alzheimer


Paeonol acting as a β-Secretase inhibitor an anti-apoptotic agent is used in the treatment of memory loss after ischemic stroke. Anti-inflammatory and analgesic.


This drug has been recorded in Pharmacopoeia of the People’s Republic of China (1977). At present, the dosage forms of paeonol for clinical use include tablet, ointment, injection, and plaster. Paeonol is clinically used for the treatment of fever, headache, neuralgia, muscle pain, abdominal pain, rheumatoid arthritis and rheumatoid arthritis; its ointment can also be used for a variety of eczema, dermatitis, skin itching, mosquito bite redness, and other skin diseases, also has a certain effect for allergic rhinitis, and is used for prevention of cold.


Preparation by reaction of methyl iodide, or dimethyl sulfate on resacetophenone in sodium hydroxide or potassium hydroxide solution (quantitative yield) (70–75%).


ChEBI: A natural product found in Paeonia rockii subspecies rockii.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG


Paeonol has a wide range of pharmacological activities, and its antibacterial, antiinflammatory, antipyretic, analgesic, and antispasmodic pharmacological effects have been well known. With the recent further study of pharmacological effects of paeonol, the improvement of cardiovascular and cerebrovascular function, liver and kidney care, and antitumor, immune regulation, antioxidant, and other new pharmacological activities have also been reported successively. Studies have shown that the protective effects of paeonol on cardiovascular and cerebrovascular systems are displayed in three aspects: it has antiarrhythmic activity because of the blocking effect on calcium channel current; it can affect the endothelial cell inflammatory response, thus protecting the blood vessels and improving blood circulation; and it can stabilize the cell membrane and inhibit myocardial ischemia and membrane damage. Paeonol inhibits the proliferation of a variety of tumor cells, such as human leukemia cell line K562, human breast cancer gene T6-17, hepatocellular carcinoma cell line BEL-7404, hepatoma cell line HepA, human leukemia tumor cell line K562/ADM, cervical cancer cell line HeLa, human large intestine cancer cell line HT-29, and so on. It can also sensitize the multidrug resistance of tumor cells to the chemotherapy drugs. Low concentration of paeonol can increase the proportion of T lymphocytes in the blood circulation and also make T lymphocytes play a stronger lymphokine separation function but also can promote the non-specific phagocytic removal of bacteria function of neutrophil. The role of systemic cellular immunity and humoral immune function has also been experimentally confirmed. In addition, paeonol has a strong effect on scavenging free radical; its antioxidant effect also enables paeonol’s applications in the pharmaceutical field and food preservation industry.

Clinical Use

In clinical practice, paeonol is mainly used as a major active ingredient of multiflavor traditional Chinese medicine. For example, paeonol is the main active ingredient and quality control index of more than ten kinds of commonly used Chinese medicine preparations, such as Feng Shi Ding tablets, Liu Wei Di Huang pills, Zheng Gu Shui water, Gui Shao Di Huang Tang pills, Mai Wei Di Huang pills, Qi Ju Di Huang tablets, Ming Mu Di Huang pills, Zhi Bai Di Huang pills, Gu Ci pills, Gu Ci Xiao Tong tablets, Fu Fang Yi Gan pills, Yang Yin Qing Fei Tang pills, JiSheng Shen Qi Wan pills, and Danggui Yangxue pills. In addition, paeonol can also be administered as a monomeric drug. The listed preparations are mainly paeonol injection, paeonol tablets, and paeonol ointment, clinically for the treatment of rheumatism, stomachache, and other pains, eczema, allergic dermatitis, etc. Paeonol and its preparations have the characteristics of less side effect, no addictive, nonrebound, and high security.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits acrid smoke and irritating fumes.

Paeonol Preparation Products And Raw materials

Global( 615)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 China 29803 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 22021 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-0371-86658258 China 29960 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715 CHINA 3004 58
Chengdu Biopurify Phytochemicals Ltd.
+86-+undefined-86-28-82633860 +86-+undefined-18080483897 China 3095 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254 CHINA 28229 58
Accela ChemBio Inc.
(+1)-858-699-3322 United States 19969 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 +86-19930503282 China 6095 58
Xi'an Kono chem co., Ltd.,
029-86107037 13289246953 China 2996 58

View Lastest Price from Paeonol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2022-09-29 Paeonol; Peony root bark extract
US $0.00 / KG 1KG ≥98% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
2022-02-21 Paeonol
US $80.00 / KG 5KG 99% 2000ton/moth Hebei Dongdu Import and Export Co. LTD
2022-02-14 Paeonol 552-41-0
US $36.50 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
  • Paeonol
  • US $80.00 / KG
  • 99%
  • Hebei Dongdu Import and Export Co. LTD
  • Paeonol 552-41-0
  • US $36.50 / g
  • ≥98%
  • NanJing Spring & Autumn Biological Engineering CO., LTD.
Paeonol (white powder) Paeonol, >=99% Acetophenone, 2'-hydroxy-4'-methoxy- resacetophenone,4-o-methylester Resacetophenone-4-methyl ether 4-o-methylresacetophenone PAEONOL 2-Acetyl-5-methoxyphenol 2-Hydroxy-4-methoxyphenyl methyl ketone Resacetophenone 4-O-methyl ether Paeol Paeonolum 2-Hydroxy-4-Methoxyacetop... 2-Hydroxy-4-acetoanisole 2-Hydroxy-4-acetylanisole Phenanthro [1, 2-b]furan-10, 11-dione, 6, 7, 8, 9-tetrahydro-1, 6, 6-triMethyl 1-(2-Hydroxy-4-methoxyphenyl)ethan-1-one, 4-Acetyl-3-hydroxyanisole, 2-Acetyl-5-methoxyphenol, Paeonol Thepaeonol Paeonol 2'-Hydroxy-4'-methoxyacetophenone 1-(2-hydroxy-4-methoxyphenyl)-ethanon 2’-hydroxy-4’-methoxy-acetophenon PAEONOL 10%-90% NATURAL EXTRACT PAEONOL 98+% NATURAL STANDARD 2'-Hydroxy-4'-methoxyacetophenone2'-Hydroxy-4'-methoxyacetophenone PAEONOL(SH) 2''-HYDROXY-4''-METHOXYACETOPHENONE(PAEONOL) Methoxy-2-hydroxyAcetophenone 2'-Hydroxy-4'-methoxyacetophenone 2-HYDROXY-4-ACETOANISOLE 2-HYDROXY-4-ACETYLANISOLE 2'-HYDROXY-4'-METHOXYACETOPHENONE 2-HYDROXY-4-METHOXYACETOPHENONE 4'-METHOXY-2'-HYDROXYACETOPHENONE 4-METHOXY-2-HYDROXYACETOPHENONE ASISCHEM D38761 Paeonol USP/EP/BP Paeonol (Pharmaceutical Grade) paeonol extract High Quality Natural Paeonol CAS 552-41-0 TIANFU CHEM Paeonol 2'-Hydroxy-4'-methoxyacetopheone Paeonol 552-41-0 JR-6831, 1-(2-Hydroxy-4-methoxyphenyl)ethanone, 97% 1-azabicyclo[2.2.2]octan-3-one oxime hydrochloride Paeonol CRS 2'-Hydroxy-4'-methoxyacetophenone> Paeonal 1-(2-HYDROXY-4-METHOXYPHENYL)ETHAN-1-ONE Paeonol std. 2-Hydroxy-4-methoxy 1-(2-HYDROXY-4-METHOXYPHENYL)ETHANONE PEONOL Ethanone, 1-(2-hydroxy-4-methoxyphenyl)- Dan phenol Peony root bark extract 552-41-0 551-41-0 522-41-0 HOCH3OC6H3COCH3