SENECIONINE
- CAS No.
- 130-01-8
- Chemical Name:
- SENECIONINE
- Synonyms
- SENECIONIN;qlgn;Aureine;Sencionine;SENECIONINE;Senecionine/Aureine;16-dione,12-hydroxy-senecionan-1;12-Hydroxysenecionan-11,16-dione;Senecionan-11,16-dione, 12-hydroxy-;(15cis)-12-Hydroxysenecionan-11,16-dione
- CBNumber:
- CB6491042
- Molecular Formula:
- C18H25NO5
- Molecular Weight:
- 335.39
- MDL Number:
- MFCD00221720
- MOL File:
- 130-01-8.mol
| Melting point | 236 °C(lit.) |
|---|---|
| alpha | D25 -55.1° (c = 0.034 in chloroform) |
| Boiling point | 472.03°C (rough estimate) |
| Density | 1.266 g/cm3 |
| refractive index | 1.5100 (estimate) |
| storage temp. | −20°C |
| solubility | DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml |
| pka | 12.81±0.40(Predicted) |
| optical activity | [α]25/D 55.1°, c = 0.034% in chloroform |
| BRN | 8162955 |
| InChIKey | HKODIGSRFALUTA-JTLQZVBZSA-N |
| LogP | 0.880 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | BO6N1U5YG6 |
| EPA Substance Registry System | Senecionine (130-01-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330 | |||||||||
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VT5710000 | |||||||||
| F | 10-23 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| Toxicity | LD50 i.v. in mice: 64.12 ±2.24 mg/kg (Harris) | |||||||||
| NFPA 704 |
|
SENECIONINE price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 17806 | Senecionine ≥95.0% (GC) | 130-01-8 | 1mg | $284 | 2023-06-20 | Buy |
| Sigma-Aldrich | 17806 | Senecionine ≥95.0% (GC) | 130-01-8 | 5mg | $959 | 2023-06-20 | Buy |
| Cayman Chemical | 25145 | Senecionine ≥98% | 130-01-8 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 25145 | Senecionine ≥98% | 130-01-8 | 5mg | $168 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHL89789 | Senecionine phyproof? Reference Substance | 130-01-8 | 10mg | $514 | 2024-03-01 | Buy |
SENECIONINE Chemical Properties,Uses,Production
Description
This hepatotoxic alkaloid is widely distributed among the Senecio species, being found in S. aureus, S. ilicifolius Thunb., S. integerrirnus, S. pseudaarnica, S. squaUdus, S. viscosus and S. vulgaris. The base is laevorotatory with [α]D - 54.6° (CHCI3 ) and the crystals sublime at 130-140°CfO.2 mm. The nitrate has m.p. 214°C;[α]D - 34.2° (H2 0); the aurichloride, m.p. 186°C; the picrate, m.p. 191°C and the methiodide, m.p. 249°C. Alkaline hydrolysis furnishes retronecine and senecic acid (6-hydroxy-5-methyl-2-heptene-3 :6-dicarboxylic acid).
Description
Senecionine is a pyrrolizidine alkaloid that has been found in S. vulgaris and has hepatotoxic properties. It is metabolized by the cytochrome P450 (CYP) isoform CYP3A in the liver to the detoxification product senecionine N-oxide and reactive metabolites including dehydropyrrolizidine alkaloids and dehydrotetronecine. Senecionine (20 μM) induces mitochondrial depolarization and fragmentation in primary cultured mouse hepatocytes and increases apoptosis in a concentration-dependent manner. In rats, senecionine (35 mg/kg, p.o.) induces liver injury, increases serum levels of bilirubin and various bile acids, including taurocholic acid, glycocholic acid, and deoxycholic acid, and increases the activity of alanine aminotransferase and aspartate aminotransferase in serum. Senecionine-induced hepatotoxicity is associated with lipid peroxidation and glutathione depletion.
Uses
Senecionine is a pyrrolizidine alkaloid with the potential to affect hepatic drug metabolizing enzymes in rat cells.
Definition
ChEBI: A pyrrolizidine alkaloid isolated from the plant species of the genus Senecio.
Safety Profile
Poison by intravenous,intraperitoneal, and possibly other routes. Anexperimental teratogen. Other experimental reproductiveeffects. Mutation data reported. When heated todecomposition it emits toxic fumes of NOx.
References
Grandval, Lajoux., Cornpt. rend., 120,1120 (1895)
Grandval, Lajoux., Bull. Soc. Chirn. Fr., 13,942 (1895)
Manske., Can. J. Res., S, 651 (1931)
Manske., ibid, 14B, 6 (1936)
Barger, Blackie., J. Chern. Soc., 584 (1937)
Blackie., Pharrn. J., 138,102 (1937)
Manske., Can. J. Res., 17B, I (1939)
SENECIONINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Related articles
- Senecionine – a pyrrolizidine alkaloid
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- Aug 27，2019
View Lastest Price from SENECIONINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-11 | Senecionine
130-01-8
|
US $9.80 / KG | 1g | ＞98% | 20 tons | Career Henan Chemical Co |
-
- Senecionine
130-01-8
- US $9.80 / KG
- ＞98%
- Career Henan Chemical Co