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(R)-Phenylephrine Hydrochlorid

(R)-Phenylephrine Hydrochlorid
(R)-Phenylephrine Hydrochlorid structure
CAS No.
61-76-7
Chemical Name:
(R)-Phenylephrine Hydrochlorid
Synonyms
uri;fenox;efricel;emagrin;lexatol;rhinall;synasal;almefrin;consdrin;fenilfar
CBNumber:
CB6762113
Molecular Formula:
C9H13NO2.ClH
Formula Weight:
203.67
MOL File:
61-76-7.mol

(R)-Phenylephrine Hydrochlorid Properties

Melting point:
143-145 °C(lit.)
alpha 
-47 º (c=2, H2O)
refractive index 
-45.5 ° (C=1, H2O)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
Freely soluble in water and in ethanol (96 per cent).
form 
Crystalline Powder
pka
pK1 8.77; pK2 9.84(at 25℃)
color 
White to almost white
PH
pH (10g/L, 25℃) : 4.5~5.5
Water Solubility 
>=10 g/100 mL at 21 ºC
Merck 
14,7286
BRN 
4158948
FDA 21 CFR
341.20
CAS DataBase Reference
61-76-7(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
04JA59TNSJ
EPA Substance Registry System
Phenylephrine hydrochloride (61-76-7)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370-H302-H315-H319-H335
Precautionary statements  P301+P312+P330-P305+P351+P338-P261-P210-P260-P280-P301+P310-P311
Hazard Codes  Xn,T,F
Risk Statements  22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements  26-36-37/39-45-36/37-16-7
RIDADR  3249
WGK Germany  3
RTECS  DO7525000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29225090
Toxicity LD50 in rats (mg/kg): 17 ±1.1 i.p.; 33 ±2.0 s.c. (Warren, Werner)

(R)-Phenylephrine Hydrochlorid price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P-078 R(-)-Phenylephrine hydrochloride solution 61-76-7 078-1ml $75.2 2020-08-18 Buy
Sigma-Aldrich P-078 R-(-)-Phenylephrine hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 61-76-7 1 mL $77.6 2021-03-22 Buy
Sigma-Aldrich P8155 (R)-(−)-Phenylephrine hydrochloride analytical standard 61-76-7 1 vial $136 2021-03-22 Buy
Sigma-Aldrich S49329 N-(2,2-DICHLORO-1-CYANO-VINYL)-4-METHYL-BENZAMIDE AldrichCPR 61-76-7 100MG $144 2021-03-22 Buy
Sigma-Aldrich P1250000 Phenylephrine hydrochloride European Pharmacopoeia (EP) Reference Standard 61-76-7 $190 2021-03-22 Buy

(R)-Phenylephrine Hydrochlorid Chemical Properties,Uses,Production

Chemical Properties

white to almost white crystalline powder

Chemical Properties

Phenylephrine Hydrochloride is white or nearly white crystalline substance, odorless, bitter taste. Solutions are acid to litmus paper, freely soluble in water and in alcohol. Levorotatory in solution.

Originator

Neosynephrine, Badrial, France ,1953

Uses

Phenylephrine hydrochloride is used medically as a vasoconstrictor and pressor drug. It is chemically related to epinephrine and ephedrine. Actions are usually longer lasting than the latter two drugs. The action of phenylephrine hydrochloride contrasts sharply with epinephrine and ephedrine, in that its action on the heart is to slow the rate and to increase the stroke output, inducing no disturbance in the rhythm of the pulse. In therapeutic doses, it produces little if any stimulation of either the spinal cord or cerebrum. The drug is intended for the maintenance of an adequate level of blood pressure during spinal and inhalation anesthesia and for the treatment of vascular failure in shock, shock-like states, and drug-induced hypotension, or hypersensitivity. It is also used to overcome paroxysmal supraventricular tachycardia, to prolong spinal anesthesia, and as a vasoconstrictor in regional analgesia. Caution is required in the administration of phenylephrine hydrochloride to elderly persons, or to patients with hyperthyroidism, bradycardia, partial heart block, myocardial disease, or severe arteriosclerosis. The brand name Neo-Synephrine? is also used to designate another product (nose drops) which does not contain phenylephrine hydrochloride. The nose drops contain xylometazoline hydrochloride.

Uses

α-Adrenergic agonist. Mydriatic; decongestant.

Uses

DECONGESTANTS

Definition

ChEBI: A hydrochloride that is the monohydrochloride salt of phenylephrine.

Manufacturing Process

4.5 g of the hydrochloride of m-hydroxymethylaminoacetophenone aredissolved in a small amount of water; to the solution a solution of colloidal palladium obtained from palladiumchloride is added, and the mixture is treated with hydrogen.
After diluting the reaction liquid with acetone it is filtered, and the residue obtained after the evaporation of the filtrate in vacuo, and complete drying over pentoxide of phosphorus is then dissolved in absolute alcohol, and to this is added about the same volume of dry ether, until turbidity just commences to occur. After a short time the hydrochloride of the m-hydroxyphenylethanolmethylamine will separate out as a colorless mass of crystals at a melting point of 142°C to 143°C.

brand name

Afrin 4 Hour Nasal Spray (Schering-Plough Health Care); Biomydrin (Parke-Davis); Mydfrin (Alcon); Neo-Synephrine (Sterling Health U.S.A.); Nostril (Boehringer Ingelheim).

Therapeutic Function

Adrenergic

General Description

Odorless white microcrystalline powder. Bitter taste. pH (1% aqueous solution) about 5.

Air & Water Reactions

May be sensitive to prolonged exposure to air and light. Water soluble.

Reactivity Profile

Phenylephrine hydrochloride is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents. Phenylephrine hydrochloride is also incompatible with butacaine, alkalis and ferric salts.

Fire Hazard

Flash point data for Phenylephrine hydrochloride are not available; however, Phenylephrine hydrochloride is probably combustible.

Biological Activity

α 1 -adrenoceptor agonist; pK i values are 5.86, 4.87 and 4.70 for α 1D , α 1B and α 1A receptors respectively.

Contact allergens

Phenylephrine hydrochloride is an alpha-adrenergic agonist, used as a mydriatic and decongestant in eyedrops.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, intravenous,and intramuscular routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Veterinary Drugs and Treatments

Phenylephrine is a vasoconstrictor used to differentiate conjunctival vascular injection (blanches with phenylephrine application) versus deep episcleral injection (blanches incompletely) associated with uveitis, glaucoma, or scleritis. It is also used prior to conjunctival surgery to reduce hemorrhage and in combination with atropine prior to cataract or other intraocular surgeries that require maximal pupillary dilation. Phenylephrine can be used to confirm the diagnosis of Horner’s syndrome. Dilution of 2.5% phenylephrine solution with saline (1:10) produces a 0.25% solution. Normal eyes will not demonstrate mydriasis in response to this low concentration of phenylephrine. Third order Horner’s syndrome of greater than two weeks duration is associated with receptor up regulation and therefore a response to 0.25% phenylephrine is noted. In this way, the diagnosis of Horner’s is confirmed and a suggestion as to whether or not the condition is 2nd or 3rd order in nature.
In dogs, maximum mydriasis persists for about 2 hours and effects may last for up to 18 hours. Phenylephrine has significant alpha adrenergic effects (vasoconstriction and pupillary dilation) and minimal effects on beta receptors. When used alone, phenylephrine is reportedly not efficacious in the cat unless used with other mydriatics.

(R)-Phenylephrine Hydrochlorid Preparation Products And Raw materials

Raw materials

Preparation Products


(R)-Phenylephrine Hydrochlorid Suppliers

Global( 338)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
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027-59599243 linda@hubeijusheng.com CHINA 28229 58
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+86 319 5273535
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Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
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Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58

View Lastest Price from (R)-Phenylephrine Hydrochlorid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-29 Phenylephrine hydrochloride
61-76-7
US $0.00-0.00 / Kg/Drum 1KG 98.0%-102%;USP 500kg WUHAN FORTUNA CHEMICAL CO., LTD
2021-09-14 (R)-Phenylephrine Hydrochlorid
61-76-7
US $444.40 / g 10g 99% 200kg Baoji Guokang Healthchem co.,ltd
2021-08-31 Phenylephrine Hydrochloride
61-76-7
US $10.00 / KG 1KG 99.99% 20 tons/month Wuhan Monad Medicine Tech Co.,LTD

(R)-Phenylephrine Hydrochlorid Spectrum


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