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MECLOFENAMATE SODIUM

MECLOFENAMATE SODIUM Structure
MECLOFENAMATE SODIUM structure
CAS No.
6385-02-0
Chemical Name:
MECLOFENAMATE SODIUM
Synonyms
ci583;C02996;Movens;meclomen;Meclonax;Meclofenamate;sodiummeclophenamate;SODIUM MECLOFENAMATE;MECLOFENAMATE SODIUM;MECLOFENAMATESODIUM,USP
CBNumber:
CB7102365
Molecular Formula:
C14H10Cl2NO2.Na
Molecular Weight:
318.13
MDL Number:
MFCD00941475
MOL File:
6385-02-0.mol
MSDS File:
SDS
Last updated:2023-07-21 17:23:12
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MECLOFENAMATE SODIUM Properties

Melting point 287-291 °C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
form White solid.
color White to Off-White
Water Solubility Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
Merck 14,5779
Stability Hygroscopic
FDA UNII 9MMQ0YER4E
NCI Drug Dictionary meclofenamate sodium

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
WGK Germany  3
RTECS  CB2975500
HS Code  2922498050
NFPA 704
0
3 0

MECLOFENAMATE SODIUM price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M4531 Meclofenamic acid sodium salt 6385-02-0 1g $56.6 2024-03-01 Buy
Sigma-Aldrich 1377803 Meclofenamate Sodium United States Pharmacopeia (USP) Reference Standard 6385-02-0 500mg $467 2024-03-01 Buy
TCI Chemical M1269 Sodium Meclofenamate 6385-02-0 1G $63 2024-03-01 Buy
TCI Chemical M1269 Sodium Meclofenamate Hydrate >98.0%(HPLC)(N) 6385-02-0 10g $372 2024-03-01 Buy
Alfa Aesar J60484 Meclofenamic acid sodium salt, 99+% 6385-02-0 1g $43.65 2024-03-01 Buy
Product number Packaging Price Buy
M4531 1g $56.6 Buy
1377803 500mg $467 Buy
M1269 1G $63 Buy
M1269 10g $372 Buy
J60484 1g $43.65 Buy

MECLOFENAMATE SODIUM Chemical Properties,Uses,Production

Description

Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.

Originator

Meclomen,Warner Lambert,US,1980

Uses

antiinflammatory, antipyretic

Uses

Meclofenamate Sodium is an NSAID used in the treatment of chronic pain.

Definition

ChEBI: An organic sodium salt derived from meclofenamic acid. Its monohydrate is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.

Indications

Meclofenamate sodium (Meclomen) is prescribed for rheumatoid arthritis and osteoarthritis. The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs.

Manufacturing Process

A mixture consisting of 22.7 g potassium o-bromobenzoate, 16.6 g 2,6- dichloro-3-methylaniline, 12 ml N-ethylmorpholine, 60 ml diethylene glycol dimethyl ether, and 1.0 g anhydrous cupric bromide is heated in a nitrogen atmosphere at 145°C to 155°C for 2 hours. The reaction mixture is diluted with 60 ml diethylene glycol dimethyl ether and acidified with 25 ml concentrated hydrochloric acid. The acidic mixture is diluted with 100 ml of water and the liquid phase decanted from the insoluble oil. The insoluble oil is stirred with methanol and the crystalline N-(2,6-dichloro-3-methylphenyl) anthranilic acid which separates is collected and washed with methanol. The product, after recrystallization from acetone-water mixture, melts at 248°C to 250°C.

brand name

Meclomen (Parke-Davis).

Therapeutic Function

Antiinflammatory

General Description

Meclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.

Pharmacokinetics

Meclofenamate sodium is rapidly and almost completely absorbed following oral administration, reaching peak plasma levels within 2 hours. It is highly bound to plasma proteins (99%) and has a plasma half-life of 2 to 4 hours. Metabolism involves oxidation of the methyl group, aromatic hydroxylation, monodehalogenation, and conjugation. Urinary excretion accounts for approximately 75% of the administered dose. The major metabolite is the product of 3′-methyl oxidation and has been shown to possess anti-inflammatory activity.
Metabolism of meclofenamic acid..jpg

Clinical Use

Meclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy menstrual blood loss.

MECLOFENAMATE SODIUM Preparation Products And Raw materials

Raw materials

2,6-Dichloro-3-methylaniline N-Ethylmorpholine

Preparation Products

MECLOFENAMATE SODIUM Suppliers

Global( 115)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569265 +86-18612256290 1056@dideu.com China 3581 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29220 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49999 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
AFINE CHEMICALS LIMITED 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
InvivoChem 		58
GIHI CHEMICALS CO.,LIMITED 		58
LEAPCHEM CO., LTD. 		58
Aladdin Scientific 		58

View Lastest Price from MECLOFENAMATE SODIUM manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SodiuM MeclofenaMate Monohydrate pictures 2021-07-20 SodiuM MeclofenaMate Monohydrate
6385-02-0
 US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
MECLOFENAMATE SODIUM USP/EP/BP pictures 2021-06-10 MECLOFENAMATE SODIUM USP/EP/BP
6385-02-0
 US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited

MECLOFENAMATE SODIUM Spectrum

MECLOFENAMATE SODIUM(6385-02-0)1HNMRMECLOFENAMATE SODIUM(6385-02-0)13CNMRMECLOFENAMATE SODIUM(6385-02-0)IR1MECLOFENAMATE SODIUM(6385-02-0)IR2

6385-02-0(MECLOFENAMATE SODIUM)Related Search:

MCPA SODIUM CLOFENAMIC ACID SODIUM ANTHRANILATE Meclofenamic acid MECLOFENAMATE SODIUM
N-Phenylanthranilic acid 2,6-DICHLORODIPHENYLAMINE 2-Chloro-5-methylaniline 2,6-Dichloro-3-methylaniline 2-Chloro-m-toluidine.
N-(2-CHLOROPHENYL)ANTHRANILIC ACID N-(3-METHYLPHENYL)ANTHRANILIC ACID 2-[(2-Chlorophenyl)amino]-benzaldehyde 2-[(2,6-dichlorophenyl)amino]benzoicacid (2-CHLORO-PHENYL)-PHENYL-AMINE
(2-(2,6-DICHLOROANILINO)PHENYL) METHANOL 2-(2,6-Dichloroanilino) benzaldehyde MECLOFENAMATE SODIUM USP(CRM STANDARD)

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MECLOFENAMIC ACID SODIUM SALT MONOHYDRATE Sodium Meclofenamate Monohydrate C02996 SODIUM MECLOFENAMATE meclofenamic acid sodium MECLOFENAMIC ACID SODIUM SALT 99% Meclofenamate MECLOFENAMATESODIUM,USP sodium meclofenamate (anhydrous) sodium2-((2,6-dichloro-3-methylphenyl)amino)benzoate sodiummeclophenamate MECLOFENAMATE SODIUM MECLOFENAMATE SODIUM HYDRATE MECLOFENAMATE SODIUM SALT MECLOFENAMIC ACID SODIUM SALT 2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]-BENZOIC ACID, MONOSODIUM SALT 2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]BENZOIC ACID SODIUM SALT sodium,2-(2,6-dichloro-3-methylanilino)benzoate 2-((2,6-dichloro-3-methylphenyl)amino)-benzoicacimonosodiumsalt ci583 meclomen n-(2,6-dichloro-m-tolyl)-anthranilicacimonosodiumsalt Benzoic acid, 2-[(2,6-dichloro-3-Methylphenyl)aMino]-, sodiuM salt Meclofenamate Sodium (500 mg) 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic Acid Sodium Salt Meclofenamic Acid Sodium Salt SodiuM MeclofenaMate  Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, sodium salt (1:1) 2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, sodium salt (1:1) Sodium Meclofenamate Hydrate sodium 2-(2,6-dichloro-3-methylanilino)benzoate hydrate SodiumMeclofenamateMonohydrate> Meclonax Movens 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt monohydrate MECLOFENAMATE SODIUM USP/EP/BP Meclofenamate Sodium (Meclofenamic acid sodium) Meclofenamate Sodium (1377803) Endogenous Metabolite,Meclofenamate,Inhibitor,Meclofenamic acid sodium,inhibit,Meclofenamic acid,Gap Junction Protein Sodium Meclofenamate Monohydrate, ≥ 98.0% 6385-02-0 6358-02-0 C14H10Cl2NO2NaH2O C14H10Cl2NNaO2H2O C14H10Cl2NNaO2xH2O C14H11Cl2NNaO2 Lipoxygenase (5-) and cyclooxygenase L to O Enzyme Inhibitors Enzyme Inhibitors by Enzyme Enzymes, Inhibitors, and Substrates BioChemical Biochemicals and Reagents MECLOMEN