4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL
![4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL Structure](CAS/GIF/22972-55-0.gif)
- CAS No.
- 22972-55-0
- Chemical Name:
- 4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL
- Synonyms
- ABN-CBD;Abn CBD,AbnCBD;Cannabidiol, Abnormal;Abnormal Cannabidiol (Abn-CBD);Abn-CBD (Abnormal Cannabidiol);1-Hydroxy-3-n-Pentylcannabidiol;4-(p-Mentha-1,8-dien-3-yl)-5-pentylresorcinol;8-dien-3-yl-5-pentyl-4-p-mentha-(-)-(e)-resorcino;(e)-(-)-4-p-mentha-1,8-dien-3-yl-5-pentylresorcinol;Resorcinol, 4-p-mentha-1,8-dien-3-yl-5-pentyl-, (-)-(E)-
- CBNumber:
- CB7129456
- Molecular Formula:
- C21H30O2
- Molecular Weight:
- 314.46
- MDL Number:
- MFCD08705633
- MOL File:
- 22972-55-0.mol
| Product description | Number | Pack Size | Price |
| Abnormal Cannabidiol ≥98% | 10004259 | 1mg | $26 |
| Abnormal Cannabidiol ≥98% | 10004259 | 5mg | $111 |
| Abnormal Cannabidiol ≥98% | 10004259 | 10mg | $195 |
| Abnormal Cannabidiol ≥98% | 10004259 | 25mg | $426 |
| Abn-CBD ≥97%(HPLC) | 1297 | 10 | $288 |
| Boiling point | 446.4±45.0 °C(Predicted) |
|---|---|
| Density | 1.025±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| solubility | Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml) |
| form | Powder |
| pka | 9.94±0.45(Predicted) |
| EWG's Food Scores | 1 |
| FDA UNII | T4WF2D7YPH |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501 | |||||||||
| NFPA 704 |
|
4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10004259 | Abnormal Cannabidiol ≥98% | 22972-55-0 | 1mg | $26 | 2024-03-01 | Buy |
| Cayman Chemical | 10004259 | Abnormal Cannabidiol ≥98% | 22972-55-0 | 5mg | $111 | 2024-03-01 | Buy |
| Cayman Chemical | 10004259 | Abnormal Cannabidiol ≥98% | 22972-55-0 | 10mg | $195 | 2024-03-01 | Buy |
| Cayman Chemical | 10004259 | Abnormal Cannabidiol ≥98% | 22972-55-0 | 25mg | $426 | 2024-03-01 | Buy |
| Tocris | 1297 | Abn-CBD ≥97%(HPLC) | 22972-55-0 | 10 | $288 | 2021-12-16 | Buy |
4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL Chemical Properties,Uses,Production
Description
Abnormal cannabidiol is a synthetic cannabidiol agonist of GPR55 (EC50 = 2.5 μM in a GTPγS binding assay). It is selective for GPR55 over cannabinoid (CB) receptor 1 (CB1) and CB2 (EC50s = >30 μM for both in GTPγS binding assays). It is also a full agonist at GPR18, with an EC50 value of 0.835 μM for inducing p44/42 MAPK phosphorylation in HEK293 cells expressing GPR18. Abnormal cannabidiol increases migration of BV-2 microglial cells (EC50 = 0.6 μM). It induces endothelium-dependent vasodilation via a CB1-CB2-NO-independent mechanism and inhibits vasoconstriction induced by endothelin 1 (ET-1; ) in retinal arterioles, an effect that can be blocked by the calcium-sensitive potassium channel blocker apamin . Abnormal cannabidiol also decreases blood pressure in anesthetized rats when administered intravenously at a dose of 20 μg/g or when administered directly into the rostral ventrolateral medulla at 0.4 and 0.8 μg.
Uses
Abnormal Cannabidiol is a potent and selective GPR55 agonist.Abnormal cannabidiol (Abn-CBD) is a synthetic regioisomer of cannabidiol, which unlike most other cannabinoids produces vasodilator effects, lowers blood pressure, and induces cell migration, cell proliferation and mitogen-activated protein kinase activation in microglia, but without producing any psychoactive effects.
Biological Activity
Neurobehaviorally inactive cannabinoid that acts as a selective agonist for GPR55 (EC 50 values are 2.5, >30 and >30 μ M at GPR55, CB 1 and CB 2 receptors respectively). Increases phosphorylation of protein kinases in, and migration of, human umbilical vein endothelial cells.
storage
Desiccate at -20°C
References
[1] DR. ELENA CHIURCHIù . A Novel and Practical Continuous Flow Chemical Synthesis of Cannabidiol (CBD) and its CBDV and CBDB Analogues[J]. European Journal of Organic Chemistry, 2021, 2021 8: Pages 1286-1289. DOI: 10.1002/ejoc.202001633
[2] LIGUO SONG. Development of a validated method for rapid quantification of up to sixteen cannabinoids using ultra-high-performance liquid chromatography diode-array detector with optional electrospray ionization time-of-flight mass spectrometry detection[J]. Journal of Chromatography A, 2022, 1670: Article 462953. DOI: 10.1016/j.chroma.2022.462953
4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL Preparation Products And Raw materials
Raw materials
Preparation Products
4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44815 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
