IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
- CAS No.
- 196868-63-0
- Chemical Name:
- IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
- Synonyms
- PQ401;CS-764;PQ401, >=98%;3β-Hydroxy-8;PQ-401; PQ 401;24-lanostadiene;IGF-1R Inhibitor II;PQ401 hydrochloride;24-Lanostadien-3β-ol;IGF-1R Inhibitor II, PQ401
- CBNumber:
- CB72094589
- Molecular Formula:
- C18H16ClN3O2
- Molecular Weight:
- 341.79
- MDL Number:
- MFCD00160558
- MOL File:
- 196868-63-0.mol
| Density | 1.370±0.06 g/cm3 (20 ºC 760 Torr) |
|---|---|
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: >10mg/mL |
| form | White solid |
| color | white |
| FDA UNII | 2N3LV83S8J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P0113 | PQ401 ≥98% (HPLC), powder | 196868-63-0 | 10mg | $214 | 2024-03-01 | Buy |
| Sigma-Aldrich | 407248 | IGF-1R Inhibitor II, PQ401 | 196868-63-0 | 10mg | $216 | 2024-03-01 | Buy |
| Cayman Chemical | 20979 | PQ401 | 196868-63-0 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20979 | PQ401 | 196868-63-0 | 5mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 20979 | PQ401 | 196868-63-0 | 10mg | $122 | 2024-03-01 | Buy |
IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Chemical Properties,Uses,Production
Uses
PQ 401, a novel diarylurea compound, is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R) autophosphorylation. Also used as a potential testing agent in the treatment of breast and other IGF-1-sensitive cancers.
Definition
ChEBI: 1-(5-chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea is a member of quinolines.
Biological Activity
Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC 50 value of 12 μ M. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo .
in vivo
a treatment with pq401 triple per week reduced the growth rate of mcneua cells implanted into mice [1].
storage
Store at +4°C
References
[1]. gable kl, maddux ba, penaranda c, zavodovskaya m, campbell mj, lobo m, robinson l, schow s, kerner ja, goldfine id, youngren jf. diarylureas are small-molecule inhibitors of insulin-like growth factor i receptor signaling and breast cancer cell growth. mol cancer ther. 2006 apr;5(4):1079-86.
[2]. wang h, qin j, gong s, feng b, zhang y, tao j. insulin-like growth factor-1 receptor-mediated inhibition of a-type k(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of akt. endocrinology. 2014 jan;155(1):168-79.
IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27231 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
View Lastest Price from IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-20 | IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
196868-63-0
|
US $1.00 / g | 100g | 99% | KG/T | Career Henan Chemical Co |
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- IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
196868-63-0
- US $1.00 / g
- 99%
- Career Henan Chemical Co