2-(4-broMophenyl)propanenitrile
- CAS No.
- 42186-06-1
- Chemical Name:
- 2-(4-broMophenyl)propanenitrile
- Synonyms
- 2-(4-broMophenyl)propanenitrile;2-(4-BroMo-phenyl)-propionitrile;Benzeneacetonitrile, 4-bromo-α-methyl-
- CBNumber:
- CB72604591
- Molecular Formula:
- C9H8BrN
- Molecular Weight:
- 210.07
- MDL Number:
- MFCD11036513
- MOL File:
- 42186-06-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
2-(4-broMophenyl)propanenitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | SBA18606 | 2-(4-Bromophenyl)propanenitrile | 42186-06-1 | 2g | $590 | 2026-06-05 | Buy |
| Biosynth | SBA18606 | 2-(4-Bromophenyl)propanenitrile | 42186-06-1 | 5g | $1003 | 2026-06-05 | Buy |
| Activate Scientific | AS115101 | 2-(4-Bromophenyl)propanenitrile 95% | 42186-06-1 | 1g | $155 | 2026-06-04 | Buy |
| Activate Scientific | AS115101 | 2-(4-Bromophenyl)propanenitrile 95% | 42186-06-1 | 5g | $491 | 2026-06-04 | Buy |
| Activate Scientific | AS115101 | 2-(4-Bromophenyl)propanenitrile 95% | 42186-06-1 | 25g | $1335 | 2026-06-04 | Buy |
2-(4-broMophenyl)propanenitrile Chemical Properties, Uses, Production
Synthesis Reference(s)
The Journal of Organic Chemistry, 42, p. 3114, 1977 DOI: 10.1021/jo00439a002
Synthesis
16532-79-9
74-88-4
42186-06-1
Example 649 Synthesis of 2-(4-bromophenyl)propionitrile: 2-(4-bromophenyl)acetonitrile (5.0 g, 25.5 mmol) was dissolved in anhydrous THF (70 mL) and cooled to 0°C. Sodium hydride (60 wt%, 1.5 g, 38.3 mmol) was added batchwise under stirring. The reaction mixture was stirred at room temperature for 1 hour. Subsequently, methyl iodide (1.8 mL, 28.1 mmol) was added and stirring was continued for 14 hours. Upon completion of the reaction, the reaction was carefully quenched with water at 0 °C and diluted with ethyl acetate (200 mL). The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by column chromatography (silica gel, 0-30% ethyl acetate/heptane gradient elution) to afford the target product, 2-(4-bromophenyl)propionitrile (3.8 g, 72%), as a yellow oil.ESI MS m/z 210 [C9H8BrN + H]+.
References
[1] Journal of the American Chemical Society, 2015, vol. 137, # 19, p. 6156 - 6159
[2] Patent: WO2011/123419, 2011, A1. Location in patent: Page/Page column 386
[3] Patent: WO2017/139778, 2017, A1. Location in patent: Paragraph 00487
[4] Patent: US2013/331375, 2013, A1. Location in patent: Paragraph 0178
[5] Patent: WO2018/140876, 2018, A1. Location in patent: Page/Page column 113; 115
2-(4-broMophenyl)propanenitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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