Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>6-BroMo-3,4-dihydroquinazolin-2(1H)-one

6-BroMo-3,4-dihydroquinazolin-2(1H)-one

6-BroMo-3,4-dihydroquinazolin-2(1H)-one Structure
6-BroMo-3,4-dihydroquinazolin-2(1H)-one structure
CAS No.
1246765-38-7
Chemical Name:
6-BroMo-3,4-dihydroquinazolin-2(1H)-one
Synonyms
6-Bromo-3,4-dihydroquinazolin-2(1H);6-Bromo-3,4-dihydro-1H-quizolin-2-one;6-Bromo-3,4-dihydro-1H-quinazolin-2-one;6-BroMo-3,4-dihydroquinazolin-2(1H)-one;2(1H)-Quinazolinone, 6-bromo-3,4-dihydro-
CBNumber:
CB72661154
Molecular Formula:
C8H7BrN2O
Molecular Weight:
227.06
MDL Number:
MFCD13180559
MOL File:
1246765-38-7.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:43
Product description Number Pack Size Price
6-Bromo-3,4-dihydroquinazolin-2(1H)-one B997873 10mg $45
6-Bromo-3,4-dihydroquinazolin-2(1H)-one 3456AJ 10g $1508
6-Bromo-3,4-dihydroquinazolin-2(1H)-one 3456AJ 5g $1021
6-Bromo-3,4-dihydroquinazolin-2(1H)-one 3456AJ 250mg $177
6-Bromo-3,4-dihydroquinazolin-2(1H)-one 3456AJ 1g $373
More product size
Request For Quotation

6-BroMo-3,4-dihydroquinazolin-2(1H)-one Properties

Boiling point 309.5±42.0 °C(Predicted)
Density 1.610±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 13.13±0.20(Predicted)

6-BroMo-3,4-dihydroquinazolin-2(1H)-one price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B997873 6-Bromo-3,4-dihydroquinazolin-2(1H)-one 1246765-38-7 10mg $45 2021-12-16 Buy
AK Scientific 3456AJ 6-Bromo-3,4-dihydroquinazolin-2(1H)-one 1246765-38-7 10g $1508 2021-12-16 Buy
AK Scientific 3456AJ 6-Bromo-3,4-dihydroquinazolin-2(1H)-one 1246765-38-7 5g $1021 2021-12-16 Buy
AK Scientific 3456AJ 6-Bromo-3,4-dihydroquinazolin-2(1H)-one 1246765-38-7 250mg $177 2021-12-16 Buy
AK Scientific 3456AJ 6-Bromo-3,4-dihydroquinazolin-2(1H)-one 1246765-38-7 1g $373 2021-12-16 Buy
Product number Packaging Price Buy
B997873 10mg $45 Buy
3456AJ 10g $1508 Buy
3456AJ 5g $1021 Buy
3456AJ 250mg $177 Buy
3456AJ 1g $373 Buy

6-BroMo-3,4-dihydroquinazolin-2(1H)-one Chemical Properties,Uses,Production

Synthesis

2-(AMINOMETHYL)-4-BROMOANILINE

771583-12-1

Triphosgene

32315-10-9

6-BroMo-3,4-dihydroquinazolin-2(1H)-one

1246765-38-7

Step 2: Synthesis of 6-bromo-3,4-dihydroquinazolin-2(1H)-one; Triethylamine (0.454 g, 4.5 mmol) was added slowly and dropwise to a solution of tetrahydrofuran (20 mL) containing triphosgene (0.445 g, 1.5 mmol) at 0 °C and under nitrogen protection. After stirring the reaction mixture for 30 minutes, a solution of 2-aminomethyl-4-bromoaniline (0.201 g, 1 mmol) in tetrahydrofuran (10 mL) was added slowly and dropwise. The reaction mixture was continued to be stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction mixture was diluted with water (15 mL) and the pH was adjusted to 8-9 with 1 M aqueous sodium hydroxide solution.Subsequently, it was extracted three times with ethyl acetate (30 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by recrystallization from a solvent mixture of dichloromethane and ethyl ether to afford 6-bromo-3,4-dihydroquinazolin-2-one (0.13 g, 57.5% yield) as a yellow solid.1H NMR (400 MHz, DMSO-d6) δppm: 9.12 (s, 1H), 7.29 (s, 1H), 7.27 (d, J=8.4 Hz. 1H), 6.87 (s, 1H), 6.70 (d, J=8.4Hz, 1H), 4.28 (s, 2H).

References

[1] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 62
[2] Asian Journal of Chemistry, 2014, vol. 26, # 7, p. 2031 - 2036
[3] Patent: US2015/232448, 2015, A1. Location in patent: Paragraph 0048

6-BroMo-3,4-dihydroquinazolin-2(1H)-one Preparation Products And Raw materials

Raw materials

3,4-DIHYDROQUINAZOLIN-2(1H)-ONE 2-(AMINOMETHYL)-4-BROMOANILINE Triphosgene Triethylamine Sodium hydroxide
Tetrahydrofuran

1of2

Preparation Products

6-BroMo-3,4-dihydroquinazolin-2(1H)-one Suppliers

Global( 44)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29798 58
Zhengzhou Lingzhiyue Technology Co., Ltd 		+86-0371-55074660 +8613523716970 Lingzhiyue@aliyun.com China 3145 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Beijing Ouhe Technology Co., Ltd 010-010-82967028 13522913783 2355560935@qq.com China 12000 60
Shanghai Sunway Pharmaceutical Technology Co., Ltd 18270980682 mlcheng@sunwaypharm.cn China 8669 57
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9510 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
career henan chemical co 		58
Zhengzhou Lingzhiyue Technology Co., Ltd 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Beijing Ouhe Technology Co., Ltd 60
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Shanghai Topbiochem Technology Co., Ltd 58

View Lastest Price from 6-BroMo-3,4-dihydroquinazolin-2(1H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-BroMo-3,4-dihydroquinazolin-2(1H)-one pictures 2020-01-10 6-BroMo-3,4-dihydroquinazolin-2(1H)-one
1246765-38-7
 US $1.00 / g 1g 99.0% 100kg Career Henan Chemical Co
6-BroMo-3,4-dihydroquinazolin-2(1H)-one pictures 2020-01-10 6-BroMo-3,4-dihydroquinazolin-2(1H)-one
1246765-38-7
 US $1.00 / g 1g 99.0% 100kg Career Henan Chemical Co
6-BroMo-3,4-dihydroquinazolin-2(1H)-one 6-Bromo-3,4-dihydro-1H-quinazolin-2-one 6-Bromo-3,4-dihydroquinazolin-2(1H) 2(1H)-Quinazolinone, 6-bromo-3,4-dihydro- 6-Bromo-3,4-dihydro-1H-quizolin-2-one 1246765-38-7