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Pazopanib-d6

Pazopanib-d6 Structure
Pazopanib-d6 structure
CAS No.
1219592-01-4
Chemical Name:
Pazopanib-d6
Synonyms
Pazopanib-d6;2H6]-Pazopanib;2-methyl-5-[[4-[methyl-d3-[3-methyl-2-(methyl-d3)-2H-indazol-6-yl]amino]-2-pyrimidinyl]amino]-benzenesulfonamide
CBNumber:
CB72741889
Molecular Formula:
C21H23N7O2S
Molecular Weight:
437.52
MDL Number:
MOL File:
1219592-01-4.mol
Last updated:2023-05-21 10:59:17
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Pazopanib-d6 Properties

storage temp. Store at -20°C
solubility DMF: 16 mg/ml; DMSO: 16 mg/ml
form A solid

Pazopanib-d6 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 25446 Pazopanib-d6 ≥99% deuterated forms (d1-d6) 1219592-01-4 500μg $290 2024-03-01 Buy
Cayman Chemical 25446 Pazopanib-d6 ≥99% deuterated forms (d1-d6) 1219592-01-4 1mg $549 2024-03-01 Buy
AK Scientific 3396DH 2-Methyl-5-[[4-[[3-methyl-2-(trideuteriomethyl)indazol-6-yl]-(trideuteriomethyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide 1219592-01-4 1mg $710 2021-12-16 Buy
Product number Packaging Price Buy
25446 500μg $290 Buy
25446 1mg $549 Buy
3396DH 1mg $710 Buy

Pazopanib-d6 Chemical Properties,Uses,Production

Description

Pazopanib-d6 is intended for use as an internal standard for the quantification of pazopanib by GC- or LC-MS. Pazopanib is a multi-kinase inhibitor that inhibits the VEGF receptors VEGFR1, VEGFR2, and VEGFR3 (IC50s = 10, 30, and 47 nM, respectively, in a cell-free enzyme assay).1 It also inhibits PDGFRα, PDGFRβ, and c-Kit (IC50s = 71, 84, and 74 nM, respectively, in a cell-free enzyme assay) as well as additional receptor tyrosine kinases. Pazopanib inhibits upregulation of the surface adhesion proteins ICAM-1 and VCAM-1 induced by VEGF in multiple myeloma cells cocultured with human umbilical vein endothelial cells (HUVECs) and decreases multiple myeloma cell adhesion to HUVECs.2 It also inhibits proliferation of multiple myeloma cells cocultured with HUVECs. Pazopanib (30 and 100 mg/kg) reduces tumor growth, induces apoptosis, decreases angiogenesis, and increases survival in a multiple myeloma mouse xenograft model. Formulations containing pazopanib have been used in the treatment of cancer.

References

1. Kumar, R., Knick, V.B., Rudolph, S.K., et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity Mol. Cancer Ther. 6(7),2012-2021(2007).
2. Podar, K., Tonon, G., Satler, M., et al. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma Proc. Natl. Acad. Sci. USA 103(5),19478-19483(2006).

Pazopanib-d6 Preparation Products And Raw materials

Raw materials

Preparation Products

Pazopanib-d6 Suppliers

Global( 13)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396 sales@chem-strong.com China 17993 56
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Guangzhou Juntang Technology Co., Ltd 020-36607679 13502246435 sales@dmstandards.com China 10951 58
Shanghai YuZn Pharm. Technology Co.,Ltd. 15921286451; 15921286451 2010681527@qq.com China 5062 58
LGC Science (Shanghai) Ltd. 17717235263 cindy.yang@lgcgroup.com China 11572 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Nanjing Shizhou Biology Technology Co.,Ltd 17301488900 judy.xia@synzest.com China 12584 58
Shanghai Aitixi Biotechnology Co., Ltd 18721763493 18721763493 2493172863@qq.com China 961 58
Nantong Hanfang Biotechnology Co. , Ltd. 3674309880 hanfangpharma@126.com China 30968 58
Supplier Advantage
ChemStrong Scientific Co.,Ltd 56
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Guangzhou Juntang Technology Co., Ltd 58
Shanghai YuZn Pharm. Technology Co.,Ltd. 58
LGC Science (Shanghai) Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
Shanghai Aitixi Biotechnology Co., Ltd 58
Nantong Hanfang Biotechnology Co. , Ltd. 58

1219592-01-4(Pazopanib-d6)Related Search:

1,3-DiMethyl-6-aMino-1H-indazole 3-AMINO-4-METHYLBENZENESULFONAMIDE N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Pazopanib Impurity 9 N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
5-Amino-2-methylbenzenesulfonamide 2-Ethyl-5-nitrobenzenamine ,98% 3-Methyl-6-nitroindazole 2,3-dimethyl-2H-indazol-6-amine hydrochloride 4(1H)-Pyrimidinone, 2-chloro- (9CI)
1,3-Dimethyl-6-nitro-1H-indazole 3-Methyl-6-nitro-2H-indazole 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) Pazopanib 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE
Pazopanib Related Compound 2 2-Methyl-5-nitrobenzenesulfonamide 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide

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Pazopanib-d6 2-methyl-5-[[4-[methyl-d3-[3-methyl-2-(methyl-d3)-2H-indazol-6-yl]amino]-2-pyrimidinyl]amino]-benzenesulfonamide 2H6]-Pazopanib 1219592-01-4