DL-Serine
- CAS No.
- 302-84-1
- Chemical Name:
- DL-Serine
- Synonyms
- SERINE;serin;DL-SER;2-AMINO-3-HYDROXY-PROPIONIC ACID;DL-Serin;DL-Ser-OH;DL-SERINE;Serine, dl-;H-DL-SER-OH;DL-SERINE,FCC
- CBNumber:
- CB7345179
- Molecular Formula:
- C3H7NO3
- Molecular Weight:
- 105.09
- MDL Number:
- MFCD00064223
- MOL File:
- 302-84-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| DL-Serine for synthesis | 8.41235 | 100g | $98.7 |
| DL-Serine ≥98% (TLC) | S4375 | 1kg | $725 |
| DL-Serine analytical standard | 68353 | 100mg | $51.8 |
| DL-Serine >98.0%(T) | S0034 | 25g | $21 |
| DL-Serine >98.0%(T) | S0034 | 500g | $122 |
| More product size | |||
| Melting point | 240 °C (dec.) (lit.) |
|---|---|
| Boiling point | 197.09°C (rough estimate) |
| Density | 1.53 |
| refractive index | 1.4368 (estimate) |
| FLAVIS Number | 17.020 | D,L-Serine |
| storage temp. | Store below +30°C. |
| solubility | H2O: soluble |
| form | Crystalline Powder |
| pka | 2.19(at 25℃) |
| color | White |
| Odor | Odorless |
| Water Solubility | 50.23 g/L (25 ºC) |
| Merck | 14,8460 |
| BRN | 1721402 |
| Henry's Law Constant | 3.9×1010 mol/(m3Pa) at 25℃, Saxena and Hildemann (1996) |
| Cosmetics Ingredients Functions |
FRAGRANCE HAIR CONDITIONING ANTISTATIC SKIN CONDITIONING |
| InChI | 1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7) |
| InChIKey | MTCFGRXMJLQNBG-UHFFFAOYSA-N |
| SMILES | NC(CO)C(O)=O |
| LogP | -3.460 |
| CAS DataBase Reference | 302-84-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 00PAR1C66F |
| NIST Chemistry Reference | DL-Serine(302-84-1) |
| EPA Substance Registry System | Serine (302-84-1) |
| UNSPSC Code | 85151701 |
| NACRES | NA.75 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P302+P352-P305+P351+P338-P362+P364 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VT8100000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29225000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
DL-Serine price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.41235 | DL-Serine for synthesis | 302-84-1 | 100g | $98.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | S4375 | DL-Serine ≥98% (TLC) | 302-84-1 | 1kg | $725 | 2025-07-31 | Buy |
| Sigma-Aldrich | 68353 | DL-Serine analytical standard | 302-84-1 | 100mg | $51.8 | 2022-05-15 | Buy |
| TCI Chemical | S0034 | DL-Serine >98.0%(T) | 302-84-1 | 25g | $21 | 2026-04-30 | Buy |
| TCI Chemical | S0034 | DL-Serine >98.0%(T) | 302-84-1 | 500g | $122 | 2026-04-30 | Buy |
DL-Serine Chemical Properties,Uses,Production
Description
DL-Serine is a kind of neutral aliphatic amino acids containing hydroxyl groups with polarity but being uncharged, and belongs to nonessential amino acids for human body. It has a high content in sericin silk protein and fibroin protein. It can be formed from the methyl transfer reaction of glycine. It can also be converted to pyruvate or hydroxy pyruvate through deamination. It is also an important raw material for in vivo synthesis of choline and cysteine.
Chemical Properties
DL-Serine is a kind of colorless monoclinic columnar or lamellae crystal. It is soluble in water (at 20℃, the water solubility is 380g/L), insoluble in ether and ethanol; Decomposition point: 246℃.
Uses
DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer’s treatment.
Application
Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2. Serine helps retain the skin's moisture balance.
Preparation
DL-serine is obtained by complexing glycine under the catalysis of copper ions and then combining with formaldehyde under alkaline conditions, followed by acidification, ion exchange, and crystallization in ethanol.
Definition
ChEBI: Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is an alpha-amino acid and a polar amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion.
Synthesis Reference(s)
Canadian Journal of Chemistry, 33, p. 1119, 1955 DOI: 10.1139/v55-131
The Journal of Organic Chemistry, 35, p. 1505, 1970 DOI: 10.1021/jo00830a054
Biochem/physiol Actions
NMDA agonist acting at the glycine site; precursor of glycine by serine hydroxymethyltransferase
Materials Uses
A series of dl-serine covalently modified multinuclear lanthanide implanted arsenotungstates are obtained. These compounds exhibit rapid photochromic behaviors[1].
Safety Profile
When heated to decomposition emits toxic fumes of NOx.
in vitro
DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV).
Subcutaneous injection of DL-serine increases the number and size of renal tubular cell tumors in male W rats treated with 500 or 1,000 ppm N-ethyl-N-hydroxyethylnitrosamine.
References
[1] Zheng, K., Niu, B., Lin, C., Song, Y., Ma, P., Wang, J., & Niu, J. (2023). dl-Serine covalently modified multinuclear lanthanide-implanted arsenotungstates with fast photochromism. Chinese Chemical Letters, 34 2, Article 107238. https://doi.org/10.1016/j.cclet.2022.02.043
DL-Serine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Apeloa Pharmaceutical Co., Ltd. | +86-0571-87635730 +8615858229168 | chem1022@hengdian-group.com | China | 1478 | 58 |
| DONBOO AMINO ACID COMPANY | 13063595538 | donboo@donboo.com | China | 9358 | 58 |
| Maanshan Tiantai Biotechnology Co., Ltd. | +86-0555-8889890 +86-17356584060 | GM@tiantaibio-tech.com | China | 72 | 58 |
| Wuhan Fortuna Chemical Co.,Ltd | +86-2759207851; +86-18007136271 | hk@fortunachem.com | China | 6005 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8737 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 17389186172 | 1077@dideu.com | China | 3999 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +86-18629295024 | qinhe02@xaltbio.com | China | 996 | 58 |
| Anhuyan (Hainan) Biotechnology Co., LTD | +86-18163349544 | mollylucking@foxmail.com | China | 3000 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7240 | 58 |
| Wuhan JiyunZen Tech Co., Ltd. | +86-18062099985 | Amyjiyunzen@yeah.net | China | 672 | 58 |
Related articles
- DL-Serine: History and Therapeutic Potential
- DL-Serine, essential for metabolic function and neurological development, requires dietary intake due to insufficient synthesi....
- Oct 21，2024
View Lastest Price from DL-Serine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-13 | DL-Serine
302-84-1
|
$10.00 | 1kg | 99.0~101.0% | 20 tons | Nantong Provichem Biotech Co., Ltd. | |
 |
2026-08-13 | DL-Serine
302-84-1
|
1KG | 99%min | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-07 | DL-Serine
302-84-1
|
$1.00-4.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd |
