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L-Serine

Identification test Content analysis Toxicity Usage limitation Chemical Properties Usage Production
L-Serine
L-Serine
CAS No.
56-45-1
Chemical Name:
L-Serine
Synonyms
SER;L-SER;SERINE;L-Serin;L-SERINE;H-SER-OH;L-Ser-OH;H-L-SER-OH;SERINE, L-;SERINE,USP
CBNumber:
CB5673304
Molecular Formula:
C3H7NO3
Formula Weight:
105.09
MOL File:
56-45-1.mol

L-Serine Properties

Melting point:
222 °C (dec.)(lit.)
alpha 
15.2 º (c=10, 2N HCl)
Boiling point:
197.09°C (rough estimate)
Density 
1.6
refractive index 
1.4368 (estimate)
Flash point:
150°C
storage temp. 
Store at 0-5
solubility 
H2O: 50 mg/mL
form 
powder
pka
2.19(at 25℃)
color 
White
PH
5-6 (100g/l, H2O, 20℃)
Water Solubility 
250 g/L (20 ºC)
Merck 
14,8460
Sublimation 
150 ºC
BRN 
1721404
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
56-45-1(CAS DataBase Reference)
NIST Chemistry Reference
L-Serine(56-45-1)
EPA Substance Registry System
L-Serine(56-45-1)

SAFETY

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  3
RTECS  VT8100000
3
TSCA  Yes
HS Code  29225000
Hazardous Substances Data 56-45-1(Hazardous Substances Data)

L-Serine price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 54763 L-Serine certified reference material, TraceCERT 56-45-1 100mg $89.6 2017-11-08 Buy
Sigma-Aldrich 1612506 L-Serine United States Pharmacopeia (USP) Reference Standard 56-45-1 200mg $414.05 2018-11-13 Buy
TCI Chemical S0035 L-Serine >99.0%(T) 56-45-1 5g $23 2017-12-01 Buy
TCI Chemical S0035 L-Serine >99.0%(T) 56-45-1 25g $49 2017-12-01 Buy
Alfa Aesar A11179 L-Serine, 99% 56-45-1 100g $70.7 2018-11-13 Buy

L-Serine Chemical Properties,Uses,Production

Identification test

1ml ninhydrin (TS-250) was added to 5ml sample solution (0.1%) should produce red purple or violet color. 200mg Periodic acid was added to the above solution and heated. Dissolving a sample of about 500 rag in 10 ml water, adding 200 mg of Periodic acid and heating, should produce the smell of formaldehyde.

Content analysis

Same as "DL-serine (01126)"

Toxicity

It can be used in food safely (FDA,§172.320,2000).

Usage limitation

It takes up to 8.4% of total protein quantity(FDA,§172.320,2000).

Chemical Properties

Six-sided flaky crystal or prismatic crystal, soluble in water(20℃,25g/100ml water)

Usage

Used as a biochemical reagent and food additive, Used for biochemical research, the preparation of tissue culture, and used as amino acids nutrition medicine.

Production

L-Serine can be obtained by a variety of methods. Methods common seen are as follows:
1. Obtain it though the hydrolysis of protein with a high content of L – Serine and recycled by ion exchange resin;
2. Obtain it by the reaction between ethyl formate and ethylhippurate;
3. Obtain it by using carbohydrate as the starting material through zymotechnics;
4. In alkaline condition, the raw material of  DL-serine and chloracetyl chloride reacted, then, extracted with ethyl acetate after drying by distillation, treated by active carbon, chiral separated by acylation enzyme to obtain the product;
5. Hydrolysis:
The raw material of silkworm cocoon was hydrolyzed in acid condition and separated and purified with ion exchange water. process engineering: silkworm cocoon [acid hydrolysis]→[HCl, 110℃, 24h] hydrolysate [deacidification,decoloration]→[732resin,ammonia,pH3.5-8] eluant [fractionation]→[717 resin] drips [Concentration, crystallization, and refined]→[film evaporation]→L-serine
Acid hydrolysis: Adding 30 kg silkworm cocoon to a crock, then adding 150 L HCl With a concentration of 6 mol/L, stirting heating to 110 ℃ for 24 h, after cooling below 60 ℃, filtering and washing the filter residue with pure water of five times the amount of filtrate, at five times the filtrate volume of washing, merging the  washing liquor into the filtrate to obtain 800 L of aqueous solution.
Deacidification and liquid-removal: 100L of hydrolysate flows through H + type 732 cation exchange resin column (150 mm x 2000 mm polyvinyl chloride, filled with 25L resin for each of the 2 columns) from top to bottom with a flow velocity of 100-120ml/min,
, then washed with purified water to remove pigments to obtain clear liquid without Cl-.0.3 mol/L ammonia flows through the column from top to bottom with a flow velocity of 80-100ml/min till outflow of amino acids, collecting the eluent within pH3.5-8. Finally, 1 mol/L of ammonia was used to wash Tyrosine followed by deammoniation, concentration and crystallization to obtain crude tyrosine.
Fractionation:
The above eluent was separated with 4 regular OH-type 717 Anion exchange resin columns:
Column1 50mm×2000mm, filled with 24L resin (polyvinyl chloride)
Column2 150mm×1800mm, filled with 22L resin (polyvinyl chloride)
Column3 150mm×1600mm, filled with 20L resin (polyvinyl chloride)
Column4 150mm×1400mm, filled with 10L resin (polyvinyl chloride)
Firstly, the pH value of the eluent was adjusted to 7-8 with 1mol/L NaOH Solution. Then, the eluent was separated in the first column with the flow rate of 120-150 ml/min until the saturation of the resin and washed to neutral with pure water. Column1 and column2 were connected in series, eluted using 0.1 mol/L HCl with the flow rate of 80-100 ml/min, collected 25 reagent Bottles ((1000 ml/bottle)until the appearance of amino acid in effluent. Colunm 4 was then connected in series and the elution process was continued. About 50 reagent Bottles were collected until the appearance of amino acid in effluent and the pH value of the eluent reached 2-3.
Paper chromatography was used to purify and collect extracts containing serine.
After concentration, crystallization, and refinement, the above extraction was evaporated and concentrated until crystallization occurrence. After cooling, anhydrous ethanol which is 2 times the amount of the extraction was added, stored in a refrigerator overnight, and dried after crystal precipitation to obtain L-Serine. The yield is about 4% Calculated on cocoon.
6. Hydrolysis:
Fermentation with precursor addition
The in vivo metabolism speed of L-Serine is very fast and direct fermentation production is difficult.  Generally, the method of fermentation with precursor addition is adopted. The precursors mainly include glycine, betaine and glyceric acid, among which Fermentation with glyceric acid precursor has been industrialized. Producing strains include anaerobic type and Methylotrophs.
Heterotroph, glycine produced L-Serin
glycine [Glycine rod acid , Butane Nocardia or white sarcina]→[fermentation] L-Serine.
Methylotrophs   glycine produced L-Serin
glycine[pseudomonas, Hyphomicrobium or Methanol assimilation Arthrobacter globiformis] →[fermentation] L-Serine.
7. Chemical synthesis:
DL-Serine can be synthesized by using glycolaldehyde as raw material and
and chiral separated to obtain L-Serine.
Synthesis by using glycolaldehyde as raw material
Synthesis by using diethyl bromomalonate as raw material
Synthesis by using Vinyl compounds as raw material
8. Enzymatic method:
Chemically synthesized DL-2 Oxazolidine-4-carboxylic acid (DL-OOC)
was used as raw material to produce L – serine under the catalysis of
testosterone pseudomonas produced L-OOC hydrolase or Bacillus subtilis
produced OOC racemase.
DL-2-Oxazolidine-4-carboxylic acid (DL-OOC)[L-OOC hydrolase or racemase]→L-serine

Chemical Properties

White crystalline powder

Uses

Amino acid.

Definition

ChEBI: The L-enantiomer of serine.

Biological Activity

Endogenous agonist at the inhibitory glycine receptor.

Purification Methods

A likely impurity is glycine. Crystallise L-serine from H2O by adding 4volumes of EtOH. Dry and store it in a desiccator. It sublimes at 160-170o/0.3mm with 99.7% recovery, and unracemised [Gross & Gradsky J Am

L-Serine Preparation Products And Raw materials

Raw materials

Preparation Products


L-Serine Suppliers

Global( 465)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19954 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
inquiry@dakenchem.com CHINA 22119 58
Taizhou Tianhong Biochemistry Technology Co., Ltd.
0523-86132544
0523-86201489 sales@thbiochem.com CHINA 217 60
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 500 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 663 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 894 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 10714 60

View Lastest Price from L-Serine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-01 L-Serine
56-45-1
US $150.00 / KG 1KG 99% 1000kg

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