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PICROTOXIN

PICROTOXIN
PICROTOXIN
CAS No.
124-87-8
Chemical Name:
PICROTOXIN
Synonyms
COCCULIN;Cocculus;1:1)[qr];COCCULINE;fishberry;PICROTOXIN;indianberry;picrotoxine;cocculin[qr];picrotox[qr]
CBNumber:
CB7351442
Molecular Formula:
C30H34O13
Formula Weight:
602.58
MOL File:
124-87-8.mol

PICROTOXIN Properties

Melting point:
203 °C(lit.)
alpha 
D16 -29.3° (c = 4 in abs ethanol)
Boiling point:
571.75°C (rough estimate)
Density 
1,28 g/cm3
refractive index 
1.6000 (estimate)
storage temp. 
Store at RT
solubility 
ethanol: 50 mg/mL, clear to slightly hazy
form 
powder
color 
white to light yellow
Merck 
14,7415
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T+,T,N
Risk Statements  28-52/53
Safety Statements  28-36/37/39-45-61
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS  TJ9100000
8-10
Hazard Note  Very Toxic
HazardClass  6.1(a)
PackingGroup  I
Toxicity LD50 i.p. in mice: 7.2 mg/kg (Setnikar)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

PICROTOXIN price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P1675 Picrotoxin powder 124-87-8 1g $45.6 2018-11-13 Buy
Sigma-Aldrich 528105 Picrotoxin 124-87-8 100mg $53.6 2018-11-20 Buy
TCI Chemical C0375 Picrotoxin (Picrotoxinin + Picrotin) >94.0%(HPLC) 124-87-8 1g $71 2018-11-22 Buy
TCI Chemical C0375 Picrotoxin (Picrotoxinin + Picrotin) >94.0%(HPLC) 124-87-8 5g $206 2018-11-22 Buy
Cayman Chemical 20771 Picrotoxin ≥98% (mixture of Picrotin and Picrotoxinin) 124-87-8 500mg $27 2018-11-19 Buy

PICROTOXIN Chemical Properties,Uses,Production

Description

Picrotoxin, also known as cocculin, appears as white to light beige crystalline material. It is isolated from Cocculus indicus (Fructus cocculi), fishberries, or Indian berries. Picrotoxin is a colourless, flexible, shining, prismatic crystals, or a micro-crystalline powder. It is odourless, has a very bitter taste, and is permanent in the air. Picrotoxin is soluble in hot water, readily soluble in strong ammonia water, and in aqueous solutions of sodium hydroxide, soluble in dilute acids, and alkalis as well as in glacial acetic acid, sparingly soluble in chloroform and very slightly soluble in cold water and alcohol. Picrotoxin is stable under normal temperatures and pressures and decompose when exposed to light. Picrotoxin is incompatible with strong oxidising agents, strong acids, strong bases, light.

Chemical Properties

white to off-white powder or crystals

Chemical Properties

Picrotoxin is an odorless crystalline solid with a very bitter taste.

General Description

A poisonous berry, the dried fruit of Anamirta PICROTOXIN L. Contains several substances including about one percent picrotoxin. Pure picrotoxin occurs as shiny leaflets with an intensely bitter taste or as a microcrystalline powder. Very poisonous!. Used in medicine as a central nervous system stimulant and antidote for barbiturate poisoning. Not currently regarded as a useful therapeutic agent.

Reactivity Profile

PICROTOXIN contains picrotoxin, a molecular compound of picrotoxinin and picrotin. May react with strong oxidizing agents and with strong reducing agents.

Health Hazard

Highly toxic and a dose of 20 mg may produce symptoms of severe poisoning. A human lethal dose of 1.5 mg/kg has been reported. It is an alkaloid convulsant poison.

Fire Hazard

When heated to decomposition PICROTOXIN emits acrid smoke and fumes. Avoid decomposing heat.

Biological Activity

GABA A receptor antagonist; potent CNS stimulant.

Safety Profile

A human poison by ingestion. Poison experimentally by most routes. Human systemic effects by ingestion: somnolence, gastrointestinal effects. An alkaloid convulsant poison. When heated to decomposition it emits acrid smoke and irritating fumes.

Potential Exposure

An alkaloid poison and convulsant. Used in medicine as a CNS stimulant and antidote for barbiturate poisoning. Reportedly, this material is not currently regarded as a useful therapeutic agent since it is not a selective respiratory stimulant.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Keep victim quiet and maintain normal body temperature. Effects may be delayed, keep victim under observation.

Shipping

UN3462 Toxins, extracted from living sources, solid, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3172 Toxins, extracted from living sources, (solid or liquid) Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise picrotoxin from H2O or Me2CO/H2O. The monoacetate has m 244-245o (*C6H6). [Meyer & Bruger Chem Ber 31 2958 1898, Johns et al. J Chem Soc 4717 1956, Beilstein 19 III/IV 5245.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste Disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, doublebagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

PICROTOXIN Preparation Products And Raw materials

Raw materials

Preparation Products


PICROTOXIN Suppliers

Global( 73)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15940 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24654 81
Ascent Scientific 4401179829988
4402030 700 369 customerservice@ascentscientific.co.uk United Kingdom 282 60
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1960 70
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32520 50
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9975 79
Chengdu Biopurify Phytochemicals Ltd. 86-28-82633397
+86-28-82633165 sales@biopurify.com China 1995 60
Chengdu Climax Biotech Co., Ltd. 028-83311324 QQ:1278112614
028-83311324 climaxbiotech@gmail.com China 927 58
Thermo Fisher Scientific 800-810-5118
+86-10-84193589 cnchemical@thermofisher.com China 17573 75
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12395 58

PICROTOXIN Spectrum


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