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D-(-)-PANTOLACTONE

D-(-)-PANTOLACTONE structure

CAS No.: 599-04-2

Chemical Name:: D-(-)-PANTOLACTONE

Synonyms: PANTOLACTONE;D-PANTOLACTONE;(R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one;Pantoyl lactone;Pantoyllactone;(R)-(-)-PANTOLACTONE;Dexpanthenol Lactone IMpurity;(3R)-3-hydroxy-4,4-dimethyloxolan-2-one;2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (R)-;Pantolacton

CBNumber:: CB3748921

Molecular Formula:: C6H10O3

Molecular Weight:: 130.14

MDL Number:: MFCD00005392

MOL File:: 599-04-2.mol

MSDS File:: SDS

Last updated:2026-01-13 11:18:56

Product description	Number	Pack Size	Price
Pantolactone European Pharmacopoeia (EP) Reference Standard	Y0002109	10 mg	$161
D-(?)-Pantolactone 99%	237817	5g	$34.3
Pantolactone United States Pharmacopeia (USP) Reference Standard	1494807	500mg	$1220
D-(-)-Pantolactone >98.0%(T)	P0011	25g	$52
D-(-)-Pantolactone >98.0%(T)	P0011	500g	$469
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D-(-)-PANTOLACTONE Properties

Melting point	91 °C(lit.)
Boiling point	120-122 °C15 mm Hg(lit.)
Density	1.1066 (rough estimate)
vapor pressure	0.3-3.28Pa at 15-35℃
refractive index	-50.8 ° (C=2, H2O)
Flash point	120-122°C/15mm
storage temp.	2-8°C
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Sparingly)
pka	13.12±0.40(Predicted)
form	Crystals or Crystalline Powder
color	White
Odor	cotton candy
optical activity	[α]25/D 49.8°, c = 2 in H2O
Water Solubility	almost transparency
Sensitive	Hygroscopic
Merck	14,7013
BRN	80957
Major Application	pharmaceutical (small molecule)
Cosmetics Ingredients Functions	HUMECTANT SKIN CONDITIONING
InChI	1S/C6H10O3/c1-6(2)3-9-5(8)4(6)7/h4,7H,3H2,1-2H3/t4-/m0/s1
InChIKey	SERHXTVXHNVDKA-BYPYZUCNSA-N
SMILES	CC1(C)COC(=O)[C@@H]1O
LogP	-0.973--0.46 at 22.5-25℃ and pH7.1
CAS DataBase Reference	599-04-2(CAS DataBase Reference)
FDA UNII	J288D7O0JS
EPA Substance Registry System	Pantolactone (599-04-2)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319

Precautionary statements

P264-P280-P305+P351+P338-P337+P313

Safety Statements

22-24/25

WGK Germany

3-10

TSCA

TSCA listed

HS Code

29322090

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2

NFPA 704

	1
2		1

D-(-)-PANTOLACTONE price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0002109	Pantolactone European Pharmacopoeia (EP) Reference Standard	599-04-2	10 mg	$161	2025-07-31	Buy
Sigma-Aldrich	237817	D-(?)-Pantolactone 99%	599-04-2	5g	$34.3	2025-07-31	Buy
Sigma-Aldrich	1494807	Pantolactone United States Pharmacopeia (USP) Reference Standard	599-04-2	500mg	$1220	2025-07-31	Buy
TCI Chemical	P0011	D-(-)-Pantolactone >98.0%(T)	599-04-2	25g	$52	2021-12-16	Buy
TCI Chemical	P0011	D-(-)-Pantolactone >98.0%(T)	599-04-2	500g	$469	2022-04-27	Buy

Product number	Packaging	Price	Buy
Y0002109	10 mg	$161	Buy
237817	5g	$34.3	Buy
1494807	500mg	$1220	Buy
P0011	25g	$52	Buy
P0011	500g	$469	Buy

D-(-)-PANTOLACTONE Chemical Properties,Uses,Production

Chemical Properties

WHITE CRYSTALLINE POWDER OR CRYSTALS

Uses

D-(-)-Pantolactone is a chiral auxiliary used in many asymmetric synthesis reactions.
It can be used as a chiral starting material to synthesize:

An insect sex pheromone named 1S,2S,3R-1-acetoxymethyl-2,3,4,4-tetrameth-ylcyclopentane.
(-)-Enantiomer of (R)-8-hydroxy-4,7,7-trimethyl-7,8-dihydrocyclopenta[e]isoindole-1,3(2H,6H)-dione, a norsesquiterpene alkaloid.
A bicyclic diterpene named isofregenedadiol.

Uses

D-(-)-PANTOLACTONE is an important intermediate in the synthesis of pantothenic acid as well as a degradation product of pantothneic acid in the liver. Causes disorientation and hypothermia, and prevents phenamine-induced hyperthermia.

Definition

ChEBI: (R)-pantolactone is a butan-4-olide that is dihydrofuran-2(3H)-one substituted by a hydroxy group at position 3 and two methyl groups at position 4 (the R-stereoisomer). It has a role as a Saccharomyces cerevisiae metabolite. It is functionally related to a (R)-pantoic acid.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Purification Methods

Recrystallise the lactone from Et2O/pet ether, diisopropyl ether or *C6H6/pet ether and sublime it at 25o/0.0001mm. It hydrolyses readily to the hydroxy-acid and racemises when heated above 145o. The Brucine salt has m 211-212o (from EtOH). [Kuhn & Wieland Chem Ber 73 1134 1940, and Stiller et al. J Am Chem Soc 62 1779 1940, Bental & Tishler J Am Chem Soc 68 1463 1946, Beilstein 18/1 V 22.]

D-(-)-PANTOLACTONE Preparation Products And Raw materials

Raw materials

Formaldehyde Sodium cyanide HYDROGEN CYANIDE Methanol Isobutyraldehyde

Sulfuric acid

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Preparation Products

Sodium D-pantothenate Calcium D-Pantothenate

D-(-)-PANTOLACTONE Suppliers

Global( 364)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
GetChem Co., Ltd.	+8618764156297	info@getchem.com	China	7778	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8749	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21595	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58

Supplier	Advantage
GetChem Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei xin bonus chemical co. LTD	58
Shandong chuangyingchemical Co., Ltd.	58

View Lastest Price from D-(-)-PANTOLACTONE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-06	D-(-)-PANTOLACTONE 599-04-2	US $1.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-01	D-(-)-PANTOLACTONE 599-04-2	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-06-20	D-(-)-PANTOLACTONE 599-04-2	US $0.00 / kg	1kg	99%	20tons	Hebei Yanxi Chemical Co., Ltd.

D-(-)-PANTOLACTONE
599-04-2
US $1.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

D-(-)-PANTOLACTONE
599-04-2
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

D-(-)-PANTOLACTONE
599-04-2
US $0.00 / kg
99%
Hebei Yanxi Chemical Co., Ltd.

D-(-)-PANTOLACTONE Spectrum

D-(-)-PANTOLACTONE(599-04-2)MS D-(-)-PANTOLACTONE(599-04-2)¹HNMR D-(-)-PANTOLACTONE(599-04-2)¹³CNMR D-(-)-PANTOLACTONE(599-04-2)IR1 D-(-)-PANTOLACTONE(599-04-2)IR2 D-(-)-PANTOLACTONE(599-04-2)IR3 D-(-)-PANTOLACTONE(599-04-2)Raman

599-04-2(D-(-)-PANTOLACTONE)Related Search:

H-BETA-ALA-BETA-ALA-OH (2S)-2,4-Dihydroxy-3,3-dimethylbutanoic acid (R)-Methyl 3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate Vitamin B5 Impurity 1 3,3-BIS(N,N-DIPROPANOIC ACID)

DL-Pantolactone PICROTOXIN L-Pantolactone, (S)-(+)-β,β-Dimethyl-α-hydroxy-γ-butyrolactone,(S)-(+)-PANTOLACTONE,L-PANTOLACTONE ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Bilobalide

GINKGOLIDEM Ginkgolide A Ginkgolide J PICROTOXININ Ginkgolide B

Ginkgolide C PICROTIN Gamma Butyrolactone

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(R)-()-β,β-Dimethyl-α-hydroxy-γ-butyrolactone (R)-(-)-DIHYDRO-3-HYDROXY-4,4-DIMETHYL-2(3H)-FURANONE (R)-DIHYDRO-3-HYDROXY-4,4-DIMETHYL-2(3H)-FURANONE (R)-(-)-BETA,BETA-DIMETHYL-ALPHA-HYDROXY-GAMMA-BUTYROLACTONE (R)-(-)-ALPHA-HYDROXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE R(-)-3,3-DIMETHYL-2-HYDROXY-GAMMA-BUTYROLACTONE R(-)-2-HYDROXY-3,3-DIMETHYL-GAMMA-BUTYROLACTONE PANTOIC ACID GAMMA-LACTONE PANTOLACTONE-D 2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, D-(-)- 4-dimethyl-dihydro-3-hydroxy-(theta)-2(3h)-furanon D-(-)-Pantoic acid lactone D-(-)-Pantolyl lactone dihydro-3-hydroxy-4,4-dimethyl-,(R)-2(3H)-Furanone Dihydro-4,4-dimethyl-3-hydroxy-2(3H)-furanone -Hydroxy-,-dimethyl-butyrolactone Pantoiclactone Pantolyl lactone Pantothenic lactone Pentoyl lactone Pentoyl lactone clene D-()-Pantolactone,(R)-()-α-Hydroxy-β,β-dimethyl-γ-butyrolactone, (R)-()-β,β-Dimethyl-α-hydroxy-γ-butyrolactone, (R)-()-Pantolactone, Pantoic acid γ-lactone Pan-acid lactone (-)-2-Hydroxy-3,3-diMethyl-γ-butyrolactone (3R)-Dihydro-3-hydroxy-4,4-diMethyl-2(3H)-furanone (3R)-Tetrahydro-3-hydroxy-4,4-diMethylfuran-2-one (R)-(-)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone D-(-)-2-Hydroxy-3,3-dimethyl-gamma-butyrolactone D-(-)-Pantoyl Lactone Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone D-(-)-Pantolactone 99% (R)-Pantolacton 2,4-DIHYDROXY-3,3-DIMETHYLBUTYRIC ACID GAMMA-LACTONE ALPHA-HYDROXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE D-(-)-PANTOYL LACTONE D-PANTOYL LACTONE D-PANTOIC ACID G-LACTONE (-)-D-PANTOLACTONE D-(-)-PANTOLACTONE D-ALPHA-HYDROXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE D-1-HYDROXY-2,2-DIMETHYL-3-BUTYROLACTONE D-(-)-2-HYDROXY-3,3-DIMETHYL-GAMMA-BUTYROLACTONE D-(-)-DIHYDRO-3-HYDROXY-4,4-DIMETHYL-2(3H)-FURANONE (R)-N-Pantolactone (R)-Pantoyl lactone alpha-Hydroxy-beta,beta-dimethyl-alpha-butyrolactone D-MINUS-PANTOYLLACTONE D-(-)-PANTOYL LACTONE 98+% D-(-)-Pantanolactone D-(-)-Pantolactone,99% pantolactone,dihydro-3-hydroxy-4,4-dimethyl-2(3H)-Furanone,Pantoyllactone alpha-Hydroxy-beta,beta-dimeth 2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (3R)- (r)-(-)-α-hydroxy-β,β-dimethyl-γ-butyrolactone Pantolacton (R)-(-)-Pantolactone, Pantoic acid γ-lactone, (R)-(-)-β,β-Dimethyl-α-hydroxy-γ-butyrolactone, (R)-(-)-α-Hydroxy-β,β-dimethyl-γ-butyrolactone (R)-4,5-Dihydro-3-hydroxy-4,4-dimethylfuran-2(3H)-one [R,(-)]-3-Hydroxy-4,4-dimethyl-4,5-dihydrofuran-2(3H)-one Pantolactone (500 mg) Dexpanthenol Impurity 1