1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
- CAS No.
- 941987-60-6
- Chemical Name:
- 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
- Synonyms
- H-151;H 151 NEW;H 151 (H-151);STING inhibitor;STING antagonist;H-151, 10 mM in DMSO;H-151 (STING inhibitor);H-151 10mM*1ml in DMSO;STING Antagonist (H-151);1-(4-Ethylphenyl)-3-(3-indolyl)urea
- CBNumber:
- CB74635441
- Molecular Formula:
- C17H17N3O
- Molecular Weight:
- 279.34
- MDL Number:
- MFCD08026581
- MOL File:
- 941987-60-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 399.9±25.0 °C(Predicted) |
|---|---|
| Density | 1.298±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (25 mg/ml) |
| form | solid |
| pka | 14.96±0.70(Predicted) |
| color | Off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21) |
| InChIKey | UJZDIKVQFMCLBE-UHFFFAOYSA-N |
| SMILES | N(C1=CC=C(CC)C=C1)C(NC1C2=C(NC=1)C=CC=C2)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H302-H335-H315 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2437 | H-151 ≥98% (HPLC) | 941987-60-6 | 5 mg | $113 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2437 | H-151 ≥98% (HPLC) | 941987-60-6 | 25 mg | $435 | 2026-04-30 | Buy |
| Cayman Chemical | 25857 | H-151 ≥98% | 941987-60-6 | 5mg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 25857 | H-151 ≥98% | 941987-60-6 | 10mg | $127 | 2026-04-30 | Buy |
| Cayman Chemical | 25857 | H-151 ≥98% | 941987-60-6 | 50mg | $591 | 2026-04-30 | Buy |
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Chemical Properties, Uses, Production
Description
H-151 (941987-60-6) is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.
Uses
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea (cas# 941987-60-6) is a useful research chemical. It is used in biological studies in the enhancement of transgene expression by beta-catenin inhibitor iCRT14.
in vivo
H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice[1].
H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in Trex1 / mice that expressed a bioluminescent IFNβ reporter[1].
H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice[1].
storage
Store at +4°C
References
[1] SIMONE M. HAAG. Targeting STING with covalent small-molecule inhibitors[J]. Nature, 2018, 559 7713: 269-273. DOI:10.1038/s41586-018-0287-8
[2] JOEL LEE K C M Ghonime. STING Restricts oHSV Replication and Spread in Resistant MPNSTs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation[J]. Molecular Therapy Oncolytics, 2019, 22 1: 91-100. DOI:10.1016/j.omto.2019.09.001
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Preparation Products And Raw materials
Raw materials
Preparation Products
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3307 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 18100677375 | sales@szzxbio.com | China | 1129 | 58 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4866 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
