(+)-Camptothecin
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(+)-Camptothecin Properties
- Melting point:
- 260 °C (dec.)(lit.)
- alpha
- D25 +31.3° (in chloroform-methanol, 8:2)
- Boiling point:
- 482.73°C (rough estimate)
- Density
- 1.3112 (rough estimate)
- refractive index
- 1.5700 (estimate)
- storage temp.
- 2-8°C
- solubility
- chloroform/methanol (4:1): 4 mg/mL
- pka
- pKa 10.83 (Uncertain)
- form
- solid
- color
- yellow
- Water Solubility
- insoluble
- Merck
- 14,1735
- BRN
- 631069
- InChIKey
- VSJKWCGYPAHWDS-FQEVSTJZSA-N
- CAS DataBase Reference
- 7689-03-4(CAS DataBase Reference)
- FDA UNII
- XT3Z54Z28A
- NCI Dictionary of Cancer Terms
- camptothecin
SAFETY
- Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
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|---|---|---|---|
| Signal word | Danger | ||
| Hazard statements | H301 | ||
| Precautionary statements | P264-P270-P301+P310+P330-P405-P501-P301+P310a-P321-P501a | ||
| Hazard Codes | T,Xi,Xn | ||
| Risk Statements | 36/37/38-25-20/21/22 | ||
| Safety Statements | 45-36/37/39-26-36 | ||
| RIDADR | UN 1544 6.1/PG 3 |
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| WGK Germany | 3 |
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| RTECS | UQ0492000 |
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| Hazard Note | Irritant | ||
| HazardClass | 6.1 | ||
| PackingGroup | Ⅲ | ||
| HS Code | 29399990 |
(+)-Camptothecin price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C1495 | (S)-(+)-Camptothecin >97.0%(HPLC) | 7689-03-4 | 1g | $373 | 2020-06-24 | Buy |
| TCI Chemical | C1495 | (S)-(+)-Camptothecin >97.0%(HPLC) | 7689-03-4 | 100mg | $62 | 2020-06-24 | Buy |
| Alfa Aesar | J62523 | Camptothecin | 7689-03-4 | 5g | $619 | 2020-06-24 | Buy |
| Alfa Aesar | J62523 | Camptothecin | 7689-03-4 | 1g | $155 | 2020-06-24 | Buy |
| Cayman Chemical | 11694 | Camptothecin ≥98% | 7689-03-4 | 50mg | $20 | 2020-06-24 | Buy |
(+)-Camptothecin Chemical Properties,Uses,Production
Chemical Properties
light yellow crystal powdeUses
Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agentUses
antineoplasticUses
Antitumor agent;Topoisomerase I inhibitorUses
10-hydroxycamptothecine precursor, topoisomerase inhibitor, binds irreversibly to DNA-topoisomerase I complexDefinition
ChEBI: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).Biological Activity
Cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor.Anticancer Research
Camptothecin (CPT) is a monoterpene indole alkaloid which is isolatedfrom the Chinese plant, Camptotheca acuminata (Nyssaceae) (Wall et al. 1966).CPT is used in cancer treatment since it is a potent inhibitor of DNA topoisomeraseI, which leads to DNA damage and the apoptosis in cancer cells. Studies have shownthat CPT itself is not suitable for clinical application since it has low water solubilityand certain side effects; therefore, water-soluble CPT derivatives such as topotecan and irinotecan were synthesized and have been successfully used for thetreatment of ovarian, lung, and colorectal cancers, and CPT has been approved by theFood and Drug Administration (FDA) of the USA. Currently, topotecan and irinotecanare all synthesized from natural camptothecin which is mainly extracted fromCamptotheca acuminata (Beegum et al. 2007). Subsequently, CPT was also recognizedand extracted from other plant species such as Ervatamia heyneana (Gunasekeraet al. 1979), Melliodendron megacarpum (Arisawa et al. 1981), Nothapodytes foetida(Govindachari and Viswanathan 1972), and Ophiorrhiza species (Beegum et al.2007). However, the extraction of CPT from plants is limited because of low yields(about 1 mg/g dry weight) and scanty natural resources (Lopez-Meyer et al. 1994),and scientists have used biotechnological ways especially cell culture methods forthe production of CPT and its derivatives (Kai et al. 2015).Anticancer Research
CPT is extracted from Camptotheca acuminata, also called Chinese ornamentaltree. Irinotecan and topotecan are semisynthetic derivatives of camptothecin, whichcan be used for the therapy of colorectal and ovarian and small cell lung carcinoma,respectively (Shoeb 2006). Camptothecin is a potent antitumor agent that targetstopoisomerase I (Desai et al. 2008). The synthetic derivatives of camptothecin[20-(S)-9-nitrocamptothecin and 20-(S)-camptothecin] have the antitumor effects inbreast, prostate, and melanoma cancers. CPT-11 is a new derivative that showsantitumor effects against metastatic colorectal cancer (Hosseini and Ghorbani2015). It selectively inhibits topoisomerase I which is involved in cleavage andreassembly of DNA (Balunas and Kinghorn 2005). Camptothecin inhibits thesynthesis of nucleic acid in L-120 cells and HeLa cells (Desai et al. 2008).Anticancer Research
It has low watersolubility and sideeffects. Thus, usedfor clinical purposes.The chemicalmodification of itsderivatives (e.g.,topotecan andirinotecan) iscurrently used inchemotherapy.(+)-Camptothecin Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-Camptothecin Suppliers
Global( 466)Suppliers
| Supplier | Tel | Fax | Country | ProdList | Advantage | |
|---|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | 86-18523575427 |
sales@conier.com | CHINA | 47486 | 58 | |
| Capot Chemical Co.,Ltd. | +86（0）13336195806 +86-571-85586718 |
+86-571-85864795 | sales@capotchem.com | China | 19929 | 60 |
| Henan DaKen Chemical CO.,LTD. | +86-371-55531817 |
info@dakenchem.com | CHINA | 21837 | 58 | |
| Shanghai Bojing Chemical Co.,Ltd. | +86-21-37122233 |
+86-21-37127788 | Candy@bj-chem.com | CHINA | 497 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | 0371-55170693 |
0371-55170693 | info@tianfuchem.com | CHINA | 22625 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3623 | 58 | |
| career henan chemical co | +86-371-86658258 |
sales@coreychem.com | CHINA | 30043 | 58 | |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
+86 0531-67809011 | sales@sdzschem.com | CHINA | 2995 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | 18080483897 |
maggie@biopurify.com | CHINA | 2645 | 58 | |
| Chemwill Asia Co.,Ltd. | 86-21-51086038 |
86-21-51861608 | chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com | CHINA | 23977 | 58 |
View Lastest Price from (+)-Camptothecin manufacturers
| Image | Release date | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-11-01 |
Camptothecin 7689-03-4 |
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2020-04-30 |
Camptothecin 7689-03-4 |
US $0.00-0.00 / 公斤 | 1公斤 | 99.0% | 800 ton | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-06-25 |
Camptothecin 7689-03-4 7689-03-4 |
US $58.12 / g | 10mg | ≥98% | 100.00 kgs | NanJing Spring & Autumn Biological Engineering CO., LTD. |
7689-03-4((+)-Camptothecin)Related Search:
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,Jurkat cell Lysate (Camptothecin-treated)
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- Irinotecan EP Impurity D
- (S)-4-Ethyl-4-hydroxyl-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3, 14(4H,12H)-dione
- (20RS)-Camptothecin
- (RS)-Camptothecin
- rac-4α*-Hydroxy-4-ethyl-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
- d-Camptothecin
- (+)-Camptothecin,98%
- 5,6-DIHYDROXY-4-OXO-2-PHENYL-4H-1-BENZOPYRAN-7-YL BETA-D-GLUCOPYRANOSIDURONIC ACI
- Camptothecin,from Camptotheca acuminata
- 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza -dibenzo[b,h]fluorene-3,13-dione
- camptothecincamptothecine
- Irinotecan Impurity 14
- nsc100880
- nsc94600
- (S)-4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZO[B,H]FLUORENE-3,13-DIONE
- (S)-4-ETHYL-4-HYDROXY-1H-PYRANO-[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)-DIONE
- (S)-(+)-CAMPTOTHECIN
- Camptothecin,95%
- Camptohecin
- (S)-(+)-CAMPTOTHECINE
- Baicalin std.
- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-
- 3,14(4H,12H)-dione,4-ethyl-4-hydroxy-, (S)-
- 19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²
- ¹
- 1,6-DIHYDROXY-7-GLUCURONOSYLFLAVONE
- (20S)-CAMPTOTHECIN
- 4-ETHYL-4-HYDROXY-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)DIONE
- 5,6-DIHYDROXY-7-GLUCURONOSYLFLAVONE
- 5,6-DIHYDROXY-4-OXO-2-PHENYL-4H-1-BENZOPYRAN-7-YL BETA-D-GLUCOPYRANOSIDURONIC ACID
- CAMPTOTHECIN, CAMPTOTHECA ACUMINATA
- CAMPTOTHECINE
- (+)-CAMPTOTHECIN
- CAMPTOTHECIN
- (s)-droxy
- 1h-pyrano(3’,4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4-hy
- CaMpathecin
- CaMpetothecin
- (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- Topotecan Related CoMpound C
- CaMptothecin(NATURAL)
- (+)-Camptothecin 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- Campthecin
- 20(s)-camptothecine
- 21,22-secocamptothecin-21-oicacidlactone
- (S)-4-ethyl-4-hydroxy-1H-pyrano
- CAMPTOTHECIN (IRINOTECAN EP IMPURITY D)
- IRINOTECAN EP IMPURITY D (CAMPTOTHECIN)
- (+)-Camptothecin ( CPT )
- CS-1388
- Camptothecin 7689-03-4
- CAMPTOTHECIN(P)
- CAMPTOTHECINE 95-98%
- 7689-03-4
- 7869-03-4
- C20H16N2O4
- Quinoline Alkaloids
- Alkaloids
