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(+)-Camptothecin

(+)-Camptothecin
(+)-Camptothecin structure
CAS No.
7689-03-4
Chemical Name:
(+)-Camptothecin
Synonyms
¹CS-1388;nsc94600;nsc100880;(s)-droxy;Campthecin;Camptohecin;CaMpathecin;CAMPTOTHECIN;Baicalin std.
CBNumber:
CB2381608
Molecular Formula:
C20H16N2O4
Formula Weight:
348.35
MOL File:
7689-03-4.mol

(+)-Camptothecin Properties

Melting point:
260 °C (dec.)(lit.)
alpha 
D25 +31.3° (in chloroform-methanol, 8:2)
Boiling point:
482.73°C (rough estimate)
Density 
1.3112 (rough estimate)
refractive index 
1.5700 (estimate)
storage temp. 
2-8°C
solubility 
chloroform/methanol (4:1): 4 mg/mL
pka
pKa 10.83 (Uncertain)
form 
solid
color 
yellow
Water Solubility 
insoluble
Merck 
14,1735
BRN 
631069
InChIKey
VSJKWCGYPAHWDS-FQEVSTJZSA-N
CAS DataBase Reference
7689-03-4(CAS DataBase Reference)
FDA UNII
XT3Z54Z28A
NCI Dictionary of Cancer Terms
camptothecin
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310+P330-P405-P501-P301+P310a-P321-P501a
Hazard Codes  T,Xi,Xn
Risk Statements  36/37/38-25-20/21/22
Safety Statements  45-36/37/39-26-36
RIDADR  UN 1544 6.1/PG 3
WGK Germany  3
RTECS  UQ0492000
Hazard Note  Irritant
HazardClass  6.1
PackingGroup 
HS Code  29399990

(+)-Camptothecin price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C1495 (S)-(+)-Camptothecin >97.0%(HPLC) 7689-03-4 1g $373 2020-06-24 Buy
TCI Chemical C1495 (S)-(+)-Camptothecin >97.0%(HPLC) 7689-03-4 100mg $62 2020-06-24 Buy
Alfa Aesar J62523 Camptothecin 7689-03-4 5g $619 2020-06-24 Buy
Alfa Aesar J62523 Camptothecin 7689-03-4 1g $155 2020-06-24 Buy
Cayman Chemical 11694 Camptothecin ≥98% 7689-03-4 50mg $20 2020-06-24 Buy

(+)-Camptothecin Chemical Properties,Uses,Production

Chemical Properties

light yellow crystal powde

Uses

Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent

Uses

antineoplastic

Uses

Antitumor agent;Topoisomerase I inhibitor

Uses

10-hydroxycamptothecine precursor, topoisomerase inhibitor, binds irreversibly to DNA-topoisomerase I complex

Definition

ChEBI: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).

Biological Activity

Cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor.

Anticancer Research

Camptothecin (CPT) is a monoterpene indole alkaloid which is isolatedfrom the Chinese plant, Camptotheca acuminata (Nyssaceae) (Wall et al. 1966).CPT is used in cancer treatment since it is a potent inhibitor of DNA topoisomeraseI, which leads to DNA damage and the apoptosis in cancer cells. Studies have shownthat CPT itself is not suitable for clinical application since it has low water solubilityand certain side effects; therefore, water-soluble CPT derivatives such as topotecan and irinotecan were synthesized and have been successfully used for thetreatment of ovarian, lung, and colorectal cancers, and CPT has been approved by theFood and Drug Administration (FDA) of the USA. Currently, topotecan and irinotecanare all synthesized from natural camptothecin which is mainly extracted fromCamptotheca acuminata (Beegum et al. 2007). Subsequently, CPT was also recognizedand extracted from other plant species such as Ervatamia heyneana (Gunasekeraet al. 1979), Melliodendron megacarpum (Arisawa et al. 1981), Nothapodytes foetida(Govindachari and Viswanathan 1972), and Ophiorrhiza species (Beegum et al.2007). However, the extraction of CPT from plants is limited because of low yields(about 1 mg/g dry weight) and scanty natural resources (Lopez-Meyer et al. 1994),and scientists have used biotechnological ways especially cell culture methods forthe production of CPT and its derivatives (Kai et al. 2015).

Anticancer Research

CPT is extracted from Camptotheca acuminata, also called Chinese ornamentaltree. Irinotecan and topotecan are semisynthetic derivatives of camptothecin, whichcan be used for the therapy of colorectal and ovarian and small cell lung carcinoma,respectively (Shoeb 2006). Camptothecin is a potent antitumor agent that targetstopoisomerase I (Desai et al. 2008). The synthetic derivatives of camptothecin[20-(S)-9-nitrocamptothecin and 20-(S)-camptothecin] have the antitumor effects inbreast, prostate, and melanoma cancers. CPT-11 is a new derivative that showsantitumor effects against metastatic colorectal cancer (Hosseini and Ghorbani2015). It selectively inhibits topoisomerase I which is involved in cleavage andreassembly of DNA (Balunas and Kinghorn 2005). Camptothecin inhibits thesynthesis of nucleic acid in L-120 cells and HeLa cells (Desai et al. 2008).

Anticancer Research

It has low watersolubility and sideeffects. Thus, usedfor clinical purposes.The chemicalmodification of itsderivatives (e.g.,topotecan andirinotecan) iscurrently used inchemotherapy.

(+)-Camptothecin Preparation Products And Raw materials

Raw materials

Preparation Products


(+)-Camptothecin Suppliers

Global( 466)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47486 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21837 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2995 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2645 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58

View Lastest Price from (+)-Camptothecin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-11-01 Camptothecin
7689-03-4
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
2020-04-30 Camptothecin
7689-03-4
US $0.00-0.00 / 公斤 1公斤 99.0% 800 ton Shaanxi Dideu Medichem Co. Ltd
2019-06-25 Camptothecin 7689-03-4
7689-03-4
US $58.12 / g 10mg ≥98% 100.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.

7689-03-4((+)-Camptothecin)Related Search:

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