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R-(+)-DIOA

R-(+)-DIOA Structure
R-(+)-DIOA structure
CAS No.
81166-47-4
Chemical Name:
R-(+)-DIOA
Synonyms
Acetic acid, 2-[[(2R)-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl]oxy]-;R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid
CBNumber:
CB7506132
Molecular Formula:
C20H24Cl2O4
Molecular Weight:
399.31
MDL Number:
MFCD00069261
MOL File:
81166-47-4.mol
Last updated:2023-05-30 08:29:57
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R-(+)-DIOA Properties

Melting point 173-174 °C
Boiling point 562.2±50.0 °C(Predicted)
Density 1.307±0.06 g/cm3(Predicted)
solubility H2O: insoluble <0.11mg/mL
form solid
pka 2.80±0.10(Predicted)
color white
optical activity [α]27/D +18.1°, c = 0.7 in methanol(lit.)

SAFETY

Risk and Safety Statements

WGK Germany  3

R-(+)-DIOA price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D129 R-(+)-DIOA ≥98% (HPLC), solid 81166-47-4 10mg $320 2024-03-01 Buy
Sigma-Aldrich D129 R-(+)-DIOA ≥98% (HPLC), solid 81166-47-4 50mg $624 2024-03-01 Buy
TRC D492360 R-(+)-DIOA 81166-47-4 1mg $110 2021-12-16 Buy
American Custom Chemicals Corporation CCH0004079 R-(+)-DIOA 95.00% 81166-47-4 10MG $763.42 2021-12-16 Buy
American Custom Chemicals Corporation CCH0004079 R-(+)-DIOA 95.00% 81166-47-4 50MG $1456.52 2021-12-16 Buy
Product number Packaging Price Buy
D129 10mg $320 Buy
D129 50mg $624 Buy
D492360 1mg $110 Buy
CCH0004079 10MG $763.42 Buy
CCH0004079 50MG $1456.52 Buy

R-(+)-DIOA Chemical Properties,Uses,Production

Uses

R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system.

Uses

R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:

  • short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
  • uptake of grepafloxacin by THP-1 monocytes
  • the uptake of moxifloxacin by THP-1 monocytes

Biochem/physiol Actions

[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl?)?co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.

R-(+)-DIOA synthesis

81166-34-9
81166-47-4
Synthesis of R-(+)-DIOA from Acetic acid, 2-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-

R-(+)-DIOA Preparation Products And Raw materials

Raw materials

6,7-dichloro-2-cyclopentyl-5-methoxy-2,3-dihydro-1H-inden-1-one Acetic acid, 2-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]- 1H-Inden-1-one, 2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-5-methoxy-

Preparation Products

R-(+)-DIOA Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Supplier Advantage
Aladdin Scientific 		58
Sigma-Aldrich 80
Shanghai EFE Biological Technology Co., Ltd. 58

81166-47-4(R-(+)-DIOA)Related Search:

3-CHLORO-5-METHYLPHENOL 5-METHOXYINDAN 2-PROPYL-1-INDANONE, 98 3-METHYLPHENOXYACETIC ACID 3-CHLORO-4-METHOXYACETOPHENONE
2-CHLORO-5-METHYLPHENOL 3-Chlorophenoxyacetic acid 2,3-Dichlorophenol 4'-Hydroxyvalerophenone 2,3-DICHLOROANISOLE
3'-Chloropropiophenone 2-Chloro-4-hydroxybenzaldehyde 2,3-Dichloroacetophenone 3,4-DIMETHYLPHENOXYACETIC ACID 2-METHYL-1-INDANONE
5-Methoxy-1-indanone 2,3-DIHYDRO-2,2-DIMETHYLINDEN-1-ONE 2-(3-CHLOROPHENOXY)ETHANOL

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R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid Acetic acid, 2-[[(2R)-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl]oxy]- 81166-47-4 C20H24Cl2O4