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PELITINIB

PELITINIB Structure
PELITINIB structure
CAS No.
257933-82-7
Chemical Name:
PELITINIB
Synonyms
Pelitinib(EKB-569);PELITINIB;WAY172569;WAY 172569;WAY-172569;WAY-EKB 569;Pelitinib, >=98%;EKB-569 Pelitinib;257933-82-7 PELITINIB;PELITINIB (EKB-569;WAY-EKB 569)
CBNumber:
CB81011748
Molecular Formula:
C24H23ClFN5O2
Molecular Weight:
467.92
MDL Number:
MFCD09837868
MOL File:
257933-82-7.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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PELITINIB Properties

Melting point 173-178°C
Boiling point 655.5±55.0 °C(Predicted)
Density 1.34
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility DMSO: soluble5mg/mL, clear (warmed)
form powder
pka 12.23±0.43(Predicted)
color white to beige
NCI Dictionary of Cancer Terms pelitinib
FDA UNII X5DWL380Z6
NCI Drug Dictionary pelitinib

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2933.59.8000
HazardClass  6.1
PackingGroup  III
NFPA 704
0
3 0

PELITINIB price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0197 Pelitinib ≥98% (HPLC) 257933-82-7 5mg $149 2024-03-01 Buy
Sigma-Aldrich PZ0197 Pelitinib ≥98% (HPLC) 257933-82-7 25mg $594 2024-03-01 Buy
TCI Chemical P2529 Pelitinib >97.0%(HPLC) 257933-82-7 25mg $143 2024-03-01 Buy
TCI Chemical P2529 Pelitinib >97.0%(HPLC) 257933-82-7 100mg $389 2024-03-01 Buy
Cayman Chemical 15627 Pelitinib ≥98% 257933-82-7 1mg $44 2024-03-01 Buy
Product number Packaging Price Buy
PZ0197 5mg $149 Buy
PZ0197 25mg $594 Buy
P2529 25mg $143 Buy
P2529 100mg $389 Buy
15627 1mg $44 Buy

PELITINIB Chemical Properties,Uses,Production

Description

Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM). It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM). By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC50s = ~2 μM).

Chemical Properties

Off-White Solid

Uses

Labelled Pelitinib (P218702). A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer.

Uses

An EGFR inhibitor

Uses

Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.

Definition

ChEBI: Pelitinib is an aminoquinoline, a nitrile, a monocarboxylic acid amide and a member of monochlorobenzenes. It has a role as a protein kinase inhibitor.

target

EGFR

storage

Store at -20°C

References

[1] torrance cj, jackson pe, montgomery e, kinzler kw, vogelstein b, wissner a, nunes m, frost p, discafani cm. combinatorial chemoprevention of intestinal neoplasia. nat med. 2000 sep;6(9):1024-8.
[2] nunes m, shi c, greenberger lm. phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase b, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, ekb-569, in tumor cells and normal human keratinocytes. mol cancer ther. 2004 jan;3(1):21-7.

PELITINIB Preparation Products And Raw materials

Raw materials

Preparation Products

PELITINIB Suppliers

Global( 190)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29271 58
Baoji Guokang Bio-Technology Co., Ltd. 		0917-3909592 13892490616 gksales1@gk-bio.com China 9339 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Biochempartner 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Baoji Guokang Bio-Technology Co., Ltd. 		58

View Lastest Price from PELITINIB manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pelitinib pictures 2021-07-13 Pelitinib
257933-82-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Pelitinib pictures 2021-07-10 Pelitinib
257933-82-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
PELITINIB pictures 2019-07-10 PELITINIB
257933-82-7
 US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co
  • Pelitinib pictures
  • Pelitinib
    257933-82-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Pelitinib pictures
  • Pelitinib
    257933-82-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • PELITINIB pictures
  • PELITINIB
    257933-82-7
  • US $7.00 / KG
  • 99%
  • Career Henan Chemical Co

PELITINIB Spectrum

PELITINIB(257933-82-7)1HNMR

257933-82-7(PELITINIB)Related Search:

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AZD-9291 Canertinib PELITINIB

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PELITINIB 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)- (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide WAY-EKB 569 (2E)-N-{4-[(3-chloro-4-fluorophenyl)aMino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(diMethylaMino)but-2-enaMide (E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide (2e)-n-(4-((3-chloro-4-fluorophenyl)aMino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(diMethylaMino)-2-butenaMide pelitinib N-[4-(3-Chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)-2(E)-but·Namide EKB-569 Pelitinib Pelitinib (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide Pelitinib, >=98% (E)-N-(4-(3-Chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2- PELITINIB (EKB-569;WAY-EKB 569) EKB-569; WAY-EKB 569; EKB569; EKB 569 257933-82-7 PELITINIB Pelitinib(EKB-569) WAY 172569 WAY172569 WAY-172569 257933-82-7 C24H23ClFN5O2 C24H17D6ClFN5O2 Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Tyrosine Kinase Inhibitors pyridine All Inhibitors API Aromatics Heterocycles Isotope Labelled Compounds