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Abiraterone acetate

Abiraterone acetate
Abiraterone acetate structure
CAS No.
154229-18-2
Chemical Name:
Abiraterone acetate
Synonyms
ZYTIGA;CB 7630;Abirteroneacetate;Abiraterone Acetate;Abiraterone Acotate;Abiraterone acetate 99.5%;Abiraterone acetate ester;Abiraterone acetate, >=99%;Abiraterone acetate(CB7630);Abiraterone Acetate impurity
CBNumber:
CB81396153
Molecular Formula:
C26H33NO2
Formula Weight:
391.55
MOL File:
154229-18-2.mol

Abiraterone acetate Properties

Melting point:
127-130°C
Boiling point:
506.7±50.0 °C(Predicted)
Density 
1.14±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
form 
powder
pka
5.31±0.12(Predicted)
color 
white to beige
FDA UNII
EM5OCB9YJ6
Proposition 65 List
Abiraterone acetate
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H360-H372
Precautionary statements  P201-P260-P280-P308+P313
WGK Germany  3
RTECS  BV7992100
HS Code  2937290000

Abiraterone acetate price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1527 Abiraterone acetate ≥98% (HPLC) 154229-18-2 25mg $422 2019-12-02 Buy
Sigma-Aldrich 1000818 Abiraterone acetate United States Pharmacopeia (USP) Reference Standard 154229-18-2 200mg $1391.6 2019-12-02 Buy
TCI Chemical A2891 Abiraterone Acetate >98.0%(HPLC)(T) 154229-18-2 200mg $221 2019-12-02 Buy
TCI Chemical A2891 Abiraterone Acetate >98.0%(HPLC)(T) 154229-18-2 1g $659 2019-12-02 Buy
Cayman Chemical 15148 Abiraterone Acetate ≥98% 154229-18-2 10mg $149 2018-11-13 Buy

Abiraterone acetate Chemical Properties,Uses,Production

Description

In April 2011, the United States FDA approved abiraterone acetate (CB7630) in combination with the steroid prednisone for the treatment of metastatic castration-resistant prostate cancer (mCRPC) for patients who were previously treated with a docetaxel containing regimen for late-stage disease. Abiraterone acetate affects prostate, testicular, and adrenal androgens by irreversibly inhibiting both the lyase and hydroxylase activity of cytochrome P450 17A (CYP17) signaling pathways (IC50's of 2.9 and 4 nM, respectively) thereby decreasing testosterone levels.Most common serious adverse events for abiraterone acetate versus placebo included fluid retention (30.5% vs. 22.3%), hypokalemia (17.1% vs. 8.4%), hypertension (9.7% vs. 7.9%), hepatic transaminase abnormalities (10.4% vs. 8.1%), and cardiac abnormalities (13.3% vs. 10.4%).

Chemical Properties

Off-White Solid

Originator

Institute of Cancer Research, London (United Kingdom)

Uses

A novel steroidal inhibitor of human Cytochrome P450(17a-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.

Uses

Abiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450 (17α-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.

Uses

A steroidal inhibitor of CYP17A1 in androgen biosynthesis

Definition

ChEBI: A sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo to abiraterone. Used for treatment of metastatic castrate-resistant prostate cance .

brand name

Zytiga

Abiraterone acetate Preparation Products And Raw materials

Raw materials

Preparation Products


Abiraterone acetate Suppliers

Global( 282)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19927 60
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24698 60
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 296 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30050 58
Hebei Huanhao Biotechnology Co., Ltd.
86-18932741846 whatsapp +8618932741846
86-0311-83975816 coco@hbhuanhao.com CHINA 810 58
Shanghai Arbor Chemical Co., Ltd.
021-60451682
021-60451683 act@arborchemical.com CHINA 906 58

View Lastest Price from Abiraterone acetate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-01-02 Abiraterone Acetate
154229-18-2
US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
2019-10-30 abiraterone acetate
154229-18-2
US $60.00 / KG 10g 99.8% 10tons Hebei shuoxi biotechnology co. LTD
2019-08-01 Abiraterone acetate
154229-18-2
US $1.00 / g 1g 99% 5000 Gram/Grams per Month Cangzhou Wanyou New Material Technology Co.,Ltd

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