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Dehydroepiandrosterone

Indications and Usage Mechanisms of Action
Dehydroepiandrosterone
Dehydroepiandrosterone structure
CAS No.
53-43-0
Chemical Name:
Dehydroepiandrosterone
Synonyms
DHEA;Prestara;Astenile;Deandros;Diandron;NSC 9896;Diandrone;PRASTERONE;17-Chetovis;Andrestenol
CBNumber:
CB1475670
Molecular Formula:
C19H28O2
Formula Weight:
288.42
MOL File:
53-43-0.mol

Dehydroepiandrosterone Properties

Melting point:
149-151 °C(lit.)
alpha 
12 º (c=2, ethanol 96% 25 ºC)
Boiling point:
370.65°C (rough estimate)
Density 
1.0484 (rough estimate)
refractive index 
1.4709 (estimate)
Flash point:
9℃
storage temp. 
Hormones
pka
15.02±0.60(Predicted)
form 
Fine Crystalline Powder
color 
White
Water Solubility 
21.8mg/L(23.5 ºC)
Merck 
2871
BRN 
2058110
InChIKey
FMGSKLZLMKYGDP-USOAJAOKSA-N
CAS DataBase Reference
53-43-0
EWG's Food Scores
1-3
FDA UNII
459AG36T1B
NCI Dictionary of Cancer Terms
dehydroepiandrosterone; DHEA
NIST Chemistry Reference
5-Androstene-3«beta»-ol-17-one(53-43-0)
EPA Substance Registry System
Prasterone (53-43-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS09,GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H360-H362-H410-H225-H301+H311+H331-H370
Precautionary statements  P210-P260-P280-P301+P310-P311-P201-P263-P308+P313
Hazard Codes  Xi,T,F
Risk Statements  36/37/38-39/23/24/25-23/24/25-11
Safety Statements  26-36-24/25-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  BV8396000
HS Code  29372900

Dehydroepiandrosterone price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 252805 DHEA 53-43-0 10gm $195 2019-12-02 Buy
Sigma-Aldrich D-063 Dehydroepiandrosterone (DHEA) solution 1.0mg/mL in methanol, ampule of 1mL, certified reference material 53-43-0 063-1ml $85.7 2019-12-02 Buy
Cayman Chemical 15728 Dehydroepiandrosterone ≥97% 53-43-0 1g $35 2020-06-24 Buy
Sigma-Aldrich D4000 trans-Dehydroandrosterone ≥99% 53-43-0 10g $124 2019-12-02 Buy
Sigma-Aldrich D4000 trans-Dehydroandrosterone ≥99% 53-43-0 25g $278 2019-12-02 Buy

Dehydroepiandrosterone Chemical Properties,Uses,Production

Indications and Usage

Dehydroepiandrosterone (DHEA,) chemical name 3β-hydroxy-5alpha-androstane-17-ketone, is an esterifying 3–β–hydroxy steroid retaining 5,6 cholesterol. A white crystalline powder, soluable in ethanol, ether, and benzene, and slightly soluable in chroloform and petroleum ether. Precipitates in digitalis.
DHEA is an estrogen precursor secreted by the reticular layer of the human adrenal cortex. Prevents obesity, resists diabetes, fights cancer, fights cortical disease, and delays senility treats immune deficiencies, promotes the growth and differentiation of bone cells, and promotes the synthesis of protein. It also resists viral infections, improves memory, and relieves nervous tension. DHEA is the main ingredient in steroid hormone intermediates (such as norethindrone and bisacetylene, etc.) and in birth control, and is involved in the secretion of many adrenal hormones. It has undergone extensive clinical research on treating menopausal syndrom, chorionitis, coronary heart disease, gout, psoriasis, AIDS and so on.

Mechanisms of Action

DHEA has a thyroid stimulating effect inhibiting food and fat intake and reducing fat accumulation, etc. It improves glucose tolerance, increases insulin level and fights diabetes. It can enhance endocrine system actiity, reduce cortisol levels, and resist a variety of pathological processes. It can help the body obtain cortical antibodies. DHEA has a strong protective and synergistic effect when used to treat tumors, becuase it inhibits ribose 5-phosphate. Inhibits cancer by inhibiting excessive mitochondria (NADPH) and ribose 5-phosphate esters. Regulates the growth of pancreatic cancer cells by regulating the concentration of estrogen in blood plasma. A decline in GnRH gene expression leads to aging, and DHEA can restore GnRH neuronal activity, stopping or improving certain diseases associated with declines in DHEA by stimulating GnRH biosynthesis. Restores impaired immune response, improves T- and B-cell function, and plays an important role in enhancing the physiological activity of insulin-like growth factor (IGF-1,) and is a potentially useful drug for immunodeficiency. DHEA alone cannot directly affect the growth and differential of osteoblasts, but it can do so by influencing 1,25-dihydroxyvitamin D3. The effects of DHEA on bone mass depend on the presence and form of sex hormones in bone cells and their endrocine effects on osteoblasts. DHEA is an anabolic protein hormone which promotes protein synthesis. According to the findings of Marrero and others, feeding DHEA (0.45%) to mice increased liver weight, increasing liver mitochondria by guiding liver protein restoring RNA and protein synthesis.

Chemical Properties

white fine crystalline powder

Occurrence

DHEA is naturally occurring in yam (see Wild Yam, p. 596-597).

Uses

Major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome.

Uses

adrenocortical hormone, antidepressant

brand name

17-chetovis 17-hormoforin;Cetavister;Climatost;Dastonil;Dha-s (prasterone);Gynodian;Longevital 5000;Maxepa;Mentalormon;Mylis;Neurocotex;Psicosterone;Ro 66827;Sh 833;Ultrapla.

World Health Organization (WHO)

The World Health Organization has no information further to the above regarding preparations containing prasterone or to indicate that such preparations remain available.

Safety Profile

An experimental teratogen.Experimental reproductive effects. Questionablecarcinogen with experimental neoplastigenic data. Whenheated to decomposition it emits acrid smoke andirritating fumes.

Dehydroepiandrosterone Preparation Products And Raw materials

Raw materials

Preparation Products


Dehydroepiandrosterone Suppliers

Global( 434)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shaanxi Pioneer Biotech Co., Ltd .
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Related articles


View Lastest Price from Dehydroepiandrosterone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-07-22 dhea
US $20.00 / 公斤 10g 99 10tons Xingtai Haoxun Import and Export Trade Co., Ltd.
2020-07-23 Dehydroepiandrosterone
53-43-0
US $100.00 / Kg/Bag 1Kg/Bag Above 99% 5000kg/month Shijiazhuang Suking Biotechnology Co .,Ltd. Co., Ltd.
2019-07-03 Dehydroepiandrosterone
53-43-0
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

Dehydroepiandrosterone Spectrum


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