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Dehydroepiandrosterone

Indications and Usage Mechanisms of Action
Dehydroepiandrosterone
Dehydroepiandrosterone structure
CAS No.
53-43-0
Chemical Name:
Dehydroepiandrosterone
Synonyms
DHEA;Astenile;Deandros;Diandron;NSC 9896;Prestara;Diandrone;PRASTERONE;Andrestenol;D4000_SIGMA
CBNumber:
CB1475670
Molecular Formula:
C19H28O2
Formula Weight:
288.42
MOL File:
53-43-0.mol

Dehydroepiandrosterone Properties

Melting point:
149-151 °C(lit.)
alpha 
12 º (c=2, ethanol 96% 25 ºC)
Boiling point:
370.65°C (rough estimate)
Density 
1.0484 (rough estimate)
refractive index 
1.4709 (estimate)
Flash point:
9℃
storage temp. 
Hormones
form 
Fine Crystalline Powder
color 
White
Merck 
2871
BRN 
2058110
InChIKey
FMGSKLZLMKYGDP-USOAJAOKSA-N
CAS DataBase Reference
53-43-0
NIST Chemistry Reference
5-Androstene-3«beta»-ol-17-one(53-43-0)
EPA Substance Registry System
Androst-5-en-17- one, 3-hydroxy-, (3.beta.)-(53-43-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,T,F
Risk Statements  36/37/38-39/23/24/25-23/24/25-11
Safety Statements  26-36-24/25-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  BV8396000
HS Code  29372900
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H362 May cause harm to breast-fed children Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy/while nursing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Dehydroepiandrosterone price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 252805 DHEA 53-43-0 10gm $195 2018-11-20 Buy
Sigma-Aldrich D-063 Dehydroepiandrosterone (DHEA) solution 1.0mg/mL in methanol, ampule of 1mL, certified reference material 53-43-0 063-1ml $83.9 2018-11-20 Buy
Cayman Chemical 15728 Dehydroepiandrosterone ≥97% 53-43-0 1g $35 2018-11-13 Buy
Sigma-Aldrich D4000 trans-Dehydroandrosterone ≥99% 53-43-0 10g $122 2018-11-20 Buy
Sigma-Aldrich D4000 trans-Dehydroandrosterone ≥99% 53-43-0 25g $275 2018-11-20 Buy

Dehydroepiandrosterone Chemical Properties,Uses,Production

Indications and Usage

Dehydroepiandrosterone (DHEA,) chemical name 3β-hydroxy-5alpha-androstane-17-ketone, is an esterifying 3–β–hydroxy steroid retaining 5,6 cholesterol. A white crystalline powder, soluable in ethanol, ether, and benzene, and slightly soluable in chroloform and petroleum ether. Precipitates in digitalis.
DHEA is an estrogen precursor secreted by the reticular layer of the human adrenal cortex. Prevents obesity, resists diabetes, fights cancer, fights cortical disease, and delays senility treats immune deficiencies, promotes the growth and differentiation of bone cells, and promotes the synthesis of protein. It also resists viral infections, improves memory, and relieves nervous tension. DHEA is the main ingredient in steroid hormone intermediates (such as norethindrone and bisacetylene, etc.) and in birth control, and is involved in the secretion of many adrenal hormones. It has undergone extensive clinical research on treating menopausal syndrom, chorionitis, coronary heart disease, gout, psoriasis, AIDS and so on.

Mechanisms of Action

DHEA has a thyroid stimulating effect inhibiting food and fat intake and reducing fat accumulation, etc. It improves glucose tolerance, increases insulin level and fights diabetes. It can enhance endocrine system actiity, reduce cortisol levels, and resist a variety of pathological processes. It can help the body obtain cortical antibodies. DHEA has a strong protective and synergistic effect when used to treat tumors, becuase it inhibits ribose 5-phosphate. Inhibits cancer by inhibiting excessive mitochondria (NADPH) and ribose 5-phosphate esters. Regulates the growth of pancreatic cancer cells by regulating the concentration of estrogen in blood plasma. A decline in GnRH gene expression leads to aging, and DHEA can restore GnRH neuronal activity, stopping or improving certain diseases associated with declines in DHEA by stimulating GnRH biosynthesis. Restores impaired immune response, improves T- and B-cell function, and plays an important role in enhancing the physiological activity of insulin-like growth factor (IGF-1,) and is a potentially useful drug for immunodeficiency. DHEA alone cannot directly affect the growth and differential of osteoblasts, but it can do so by influencing 1,25-dihydroxyvitamin D3. The effects of DHEA on bone mass depend on the presence and form of sex hormones in bone cells and their endrocine effects on osteoblasts. DHEA is an anabolic protein hormone which promotes protein synthesis. According to the findings of Marrero and others, feeding DHEA (0.45%) to mice increased liver weight, increasing liver mitochondria by guiding liver protein restoring RNA and protein synthesis.

Chemical Properties

white fine crystalline powder

Uses

Major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome.

Uses

adrenocortical hormone, antidepressant

brand name

17-chetovis 17-hormoforin;Cetavister;Climatost;Dastonil;Dha-s (prasterone);Gynodian;Longevital 5000;Maxepa;Mentalormon;Mylis;Neurocotex;Psicosterone;Ro 66827;Sh 833;Ultrapla.

World Health Organization (WHO)

The World Health Organization has no information further to the above regarding preparations containing prasterone or to indicate that such preparations remain available.

Dehydroepiandrosterone Preparation Products And Raw materials

Raw materials

Preparation Products


Dehydroepiandrosterone Suppliers

Global( 385)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Kono Chem Co., Ltd
+86-132 8924 6953
info@konochemical.com CHINA 2164 58
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 295 58
Hebei Jimi Trading Co., Ltd.
+86 017772612259 +86 319 5273535
admin@hebeijimi.com CHINA 305 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 416 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Aoxuan Biological Technology Co., Ltd.
17073140108
- CHINA 147 55
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 277 58

View Lastest Price from Dehydroepiandrosterone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-01 Dehydroepiandrosterone
53-43-0
US $1.00 / kg 100g 99.9% 10tons Hebei Jimi Trading Co., Ltd.
2018-08-20 Dehydroepiandrosterone
53-43-0
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-07-26 Dehydroepiandrosterone
53-43-0
US $20.00 / KG 1KG 99% 20kg career henan chemical co

Dehydroepiandrosterone Spectrum


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