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Dehydroepiandrosterone

description Indications and Usage Mechanisms of Action
Dehydroepiandrosterone
Dehydroepiandrosterone structure
CAS No.
53-43-0
Chemical Name:
Dehydroepiandrosterone
Synonyms
DHEA;Prestara;NSC 9896;Astenile;Deandros;Diandron;DHEA DEA;Diandrone;PRASTERONE;17-Chetovis
CBNumber:
CB1475670
Molecular Formula:
C19H28O2
Formula Weight:
288.43
MOL File:
53-43-0.mol

Dehydroepiandrosterone Properties

Melting point:
149-151 °C(lit.)
alpha 
12 º (c=2, ethanol 96% 25 ºC)
Boiling point:
370.65°C (rough estimate)
Density 
1.0484 (rough estimate)
refractive index 
1.4709 (estimate)
Flash point:
9℃
storage temp. 
Hormones
form 
Fine Crystalline Powder
pka
15.02±0.60(Predicted)
color 
White
Water Solubility 
21.8mg/L(23.5 ºC)
Merck 
2871
BRN 
2058110
InChIKey
FMGSKLZLMKYGDP-USOAJAOKSA-N
CAS DataBase Reference
53-43-0
EWG's Food Scores
1-3
FDA UNII
459AG36T1B
NCI Dictionary of Cancer Terms
dehydroepiandrosterone; DHEA
NCI Drug Dictionary
prasterone
ATC code
A14AA07,G03XX01
NIST Chemistry Reference
5-Androstene-3«beta»-ol-17-one(53-43-0)
EPA Substance Registry System
Prasterone (53-43-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS09,GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H360-H362-H410-H225-H301+H311+H331-H370
Precautionary statements  P210-P260-P280-P301+P310-P311-P201-P263-P308+P313
Hazard Codes  Xi,T,F
Risk Statements  36/37/38-39/23/24/25-23/24/25-11
Safety Statements  26-36-24/25-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  BV8396000
HS Code  29372900

Dehydroepiandrosterone price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D-063 Dehydroepiandrosterone (DHEA) solution 1.0mg/mL in methanol, ampule of 1mL, certified reference material 53-43-0 063-1ml $88.7 2021-12-16 Buy
Sigma-Aldrich D-063 Dehydroepiandrosterone (DHEA) solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 53-43-0 1 mL $91.5 2021-12-16 Buy
Sigma-Aldrich 252805 DHEA - CAS 53-43-0 - Calbiochem Major secretory steroidal product of the adrenal gland. 53-43-0 10 g $195.17 2021-12-16 Buy
Sigma-Aldrich 252805 DHEA 53-43-0 10gm $203 2021-12-16 Buy
Cayman Chemical 15728 Dehydroepiandrosterone ≥97% 53-43-0 1g $35 2021-12-16 Buy

Dehydroepiandrosterone Chemical Properties,Uses,Production

description

Dehydroepiandrosterone (DHEA) is a steroid hormone that is a popular nonprescription oral “dietary supplement” used by men to enhance cognitive function, mood, libido, and athletic performance. Before 1994, DHEA was a prescription medicine. After the passage of the Dietary Supplement Health and Education Act of 1994, DHEA was reclassified as a nutritional supplement. Although sold over the counter in 25- and 50-mg strengths, DHEA is widely touted to maximize results at doses of 200 mg or higher. DHEA is banned by the International Olympic Committee and the National Collegiate Athletic Association as an anabolic agent. Limited information is available regarding potential harmful effects resulting from its supplemental use.

Indications and Usage

Dehydroepiandrosterone (DHEA,) chemical name 3β-hydroxy-5alpha-androstane-17-ketone, is an esterifying 3–β–hydroxy steroid retaining 5,6 cholesterol. A white crystalline powder, soluable in ethanol, ether, and benzene, and slightly soluable in chroloform and petroleum ether. Precipitates in digitalis.
DHEA is an estrogen precursor secreted by the reticular layer of the human adrenal cortex. Prevents obesity, resists diabetes, fights cancer, fights cortical disease, and delays senility treats immune deficiencies, promotes the growth and differentiation of bone cells, and promotes the synthesis of protein. It also resists viral infections, improves memory, and relieves nervous tension. DHEA is the main ingredient in steroid hormone intermediates (such as norethindrone and bisacetylene, etc.) and in birth control, and is involved in the secretion of many adrenal hormones. It has undergone extensive clinical research on treating menopausal syndrom, chorionitis, coronary heart disease, gout, psoriasis, AIDS and so on.

Mechanisms of Action

DHEA has a thyroid stimulating effect inhibiting food and fat intake and reducing fat accumulation, etc. It improves glucose tolerance, increases insulin level and fights diabetes. It can enhance endocrine system actiity, reduce cortisol levels, and resist a variety of pathological processes. It can help the body obtain cortical antibodies. DHEA has a strong protective and synergistic effect when used to treat tumors, becuase it inhibits ribose 5-phosphate. Inhibits cancer by inhibiting excessive mitochondria (NADPH) and ribose 5-phosphate esters. Regulates the growth of pancreatic cancer cells by regulating the concentration of estrogen in blood plasma. A decline in GnRH gene expression leads to aging, and DHEA can restore GnRH neuronal activity, stopping or improving certain diseases associated with declines in DHEA by stimulating GnRH biosynthesis. Restores impaired immune response, improves T- and B-cell function, and plays an important role in enhancing the physiological activity of insulin-like growth factor (IGF-1,) and is a potentially useful drug for immunodeficiency. DHEA alone cannot directly affect the growth and differential of osteoblasts, but it can do so by influencing 1,25-dihydroxyvitamin D3. The effects of DHEA on bone mass depend on the presence and form of sex hormones in bone cells and their endrocine effects on osteoblasts. DHEA is an anabolic protein hormone which promotes protein synthesis. According to the findings of Marrero and others, feeding DHEA (0.45%) to mice increased liver weight, increasing liver mitochondria by guiding liver protein restoring RNA and protein synthesis.

Description

Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone that is secreted primarily by the adrenal gland and is the most abundant sex steroid. Metabolites of DHEA include androstenedione (Item No. ISO60161), which subsequently may be metabolized to testosterone (Item Nos. ISO60154 | 15645) or estrone (Item Nos. ISO60165 | 10006485) which is an estradiol (Item Nos. ISO60155 | 10006315) precursor. In addition to serving as an intermediate in the biosynthesis of sex steroids, DHEA directly modulates a number of cellular and nuclear receptors.

Chemical Properties

white fine crystalline powder

Originator

Aslera ,Genelabs Technologies, Inc.

Occurrence

DHEA is naturally occurring in yam (see Wild Yam, p. 596-597).

Uses

Major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome.

Uses

adrenocortical hormone, antidepressant

Manufacturing Process

To a solution of 1 gram of 16-dehydropregnenolon-3β-acetate in 10 ml pyridine is added 0.22 gram of hydroxylamine hydrochloride, and the mixture is allowed to stand at room temperature for four days. One gram of 16dehydropregnenolon-3β-acetate oxime is dissolved in 30 ml of hot dioxane, and then the solution is cooled in an ice bath until about one-half of the dioxane has solidified. Then 1 gram of phosphorus pentachloride is added and the mixture is shaken until all the dioxane has melted. The mixture is maintained at 35°C, for seventy-five minutes, then an excess of ice is added and the solution is again allowed to stand at 35°C. After about thirty minutes, a solution of 5 ml of concentrated hydrochloric acid in 10 ml of water is added, and the mixture is diluted with water, extracted with ether and the ethereal extract washed with dilute sodium hydroxide solution. The ether is removed on a steam bath and the residue is worked up to yield dehydroisoandrosterone.

brand name

17-chetovis 17-hormoforin;Cetavister;Climatost;Dastonil;Dha-s (prasterone);Gynodian;Longevital 5000;Maxepa;Mentalormon;Mylis;Neurocotex;Psicosterone;Ro 66827;Sh 833;Ultrapla.

Therapeutic Function

Glucocorticoid

World Health Organization (WHO)

The World Health Organization has no information further to the above regarding preparations containing prasterone or to indicate that such preparations remain available.

General Description

Major secretory steroidal product of the adrenal gland. DHEA and its sulfated metabolite, DHEA-S, are negative modulators of GABAA receptors.

Biochem/physiol Actions

Product does not compete with ATP.

Safety Profile

An experimental teratogen.Experimental reproductive effects. Questionablecarcinogen with experimental neoplastigenic data. Whenheated to decomposition it emits acrid smoke andirritating fumes.

Dehydroepiandrosterone Preparation Products And Raw materials

Raw materials

Preparation Products


Dehydroepiandrosterone Suppliers

Global( 538)Suppliers
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Related articles


View Lastest Price from Dehydroepiandrosterone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-24 Dehydroepiandrosterone
53-43-0
US $1.00 / g 10g 99.5% 1000kg Guangzhou Biocar Biotechnology Co.,Ltd.
2022-01-24 Dehydroepiandrosterone
53-43-0
US $1.00-450.00 / KG 0.5KG >99% 20tons Anhui Rencheng Technology Co., Ltd
2022-01-24 DHEA
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Dehydroepiandrosterone Spectrum


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