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2-Bromo-2'-fluoroacetophenone

2-Bromo-2'-fluoroacetophenone structure

CAS No.: 655-15-2

Chemical Name:: 2-Bromo-2'-fluoroacetophenone

Synonyms: ω-BroMo-2;Vonoprazan-030;BUTTPARK 35\01-51;TAK438 Impurity 83;Vonoprazan Impurity 83;o-Fluorophenacyl BroMide;2-FLUOROPHENACYL BROMIDE;2-Fluorophenacylbromide98%;Vonolazan fumarate impurity;α-BroMo-2-fluoroacetophenone

CBNumber:: CB8182528

Molecular Formula:: C8H6BrFO

Molecular Weight:: 217.04

MDL Number:: MFCD00278796

MOL File:: 655-15-2.mol

MSDS File:: SDS

Last updated:2025-08-08 17:45:00

Product description	Number	Pack Size	Price
2-Bromo-2′-fluoroacetophenone 97%	759384	5g	$69.2
2-Bromo-2′-fluoroacetophenone 97%	759384	25g	$162.45
2-Bromo-2'-fluoroacetophenone >98.0%(GC)	B5104	5g	$123
2-Bromo-2'-fluoroacetophenone >98.0%(GC)	B5104	25g	$492
2-Bromo-2’-fluoroacetophenone	B684355	25g	$205
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2-Bromo-2'-fluoroacetophenone Properties

Melting point	25-27
Boiling point	83-85
Density	1.574 g/mL at 25 °C
refractive index	n20/D1.563
Flash point	>110 °C
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
Sensitive	Lachrymatory
Stability	Unstable in DMSO
CAS DataBase Reference	655-15-2(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363

Hazard Codes

Risk Statements

36/37/38-34

Safety Statements

26-36/37/39-45-27

RIDADR

UN 3261 8 / PGIII

WGK Germany

Hazard Note

Corrosive/Lachrymatory/Keep Cold

HazardClass

LACHRYMATOR, CORROSIVE

HazardClass

PackingGroup

III

HS Code

2914790090

NFPA 704

	0
3		0

2-Bromo-2'-fluoroacetophenone price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	759384	2-Bromo-2′-fluoroacetophenone 97%	655-15-2	5g	$69.2	2025-07-31	Buy
Sigma-Aldrich	759384	2-Bromo-2′-fluoroacetophenone 97%	655-15-2	25g	$162.45	2025-07-31	Buy
TCI Chemical	B5104	2-Bromo-2'-fluoroacetophenone >98.0%(GC)	655-15-2	5g	$123	2025-07-31	Buy
TCI Chemical	B5104	2-Bromo-2'-fluoroacetophenone >98.0%(GC)	655-15-2	25g	$492	2025-07-31	Buy
TRC	B684355	2-Bromo-2’-fluoroacetophenone	655-15-2	25g	$205	2021-12-16	Buy

Product number	Packaging	Price	Buy
759384	5g	$69.2	Buy
759384	25g	$162.45	Buy
B5104	5g	$123	Buy
B5104	25g	$492	Buy
B684355	25g	$205	Buy

2-Bromo-2'-fluoroacetophenone Chemical Properties,Uses,Production

Chemical Properties

Liquid

Uses

A new class of acetophenone-based cinchona alkaloid-derived quaternary ammonium salts were prepared and evaluated as phase-transfer catalysts in the enantioselective alkylation of glycine imine ester.

Synthesis

445-27-2

655-15-2

General procedure for the synthesis of 2-bromo-2'-fluoroacetophenone from o-fluoroacetophenone: bromine (5.8 mL) was added slowly and dropwise to a solution of 1-(2-fluorophenyl)ethanone (15.1 g) in acetic acid (150 mL). The reaction mixture was stirred at room temperature for 2 h. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The organic phase was washed sequentially with saturated aqueous sodium bicarbonate, water and saturated brine and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure to afford 2-bromo-2'-fluoroacetophenone (22.91 g, 97% yield) as a light yellow oil. The product was characterized by 1H-NMR (CDCl3): δ 4.53 (2H, d, J = 2.4 Hz), 7.13-7.20 (1H, m), 7.27-7.30 (1H, m), 7.54-7.61 (1H, m), 7.91-7.96 (1H, m).

References

[1] Patent: US2009/156642, 2009, A1. Location in patent: Page/Page column 40
[2] Patent: EP2196459, 2010, A1. Location in patent: Page/Page column 78
[3] Tetrahedron Letters, 2012, vol. 53, # 2, p. 191 - 195
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 20, p. 3763 - 3772
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 15, p. 6572 - 6582

2-Bromo-2'-fluoroacetophenone Preparation Products And Raw materials

Raw materials

1-(2-Bromoethynyl)-2-fluorobenzene 2'-Fluoroacetophenone

Preparation Products

3-(2-FLUORO-PHENYL)-ISOXAZOL-5-YLAMINE 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 881673-98-9 Benzenemethanol, α-(bromomethyl)-2-fluoro- Ethanone, 1-(2-fluorophenyl)-2-(methylthio)-

2-Bromo-2'-fluoroacetophenone Suppliers

Global( 253)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20135	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29846	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14359	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Richest Group Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58
ANHUI WITOP BIOTECH CO., LTD	58

View Lastest Price from 2-Bromo-2'-fluoroacetophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-25	2-Bromo-2'-fluoroacetophenone 655-15-2	US $8.00-3.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2022-02-19	2-Bromo-1-(2-fluorophenyl)ethanone 655-15-2	US $0.00 / KG	1KG	97.4%	100 tons	Honest Joy Holdings Limited
2019-09-02	2-Bromo-2'-fluoroacetophenone 655-15-2	US $7.00 / KG	1KG	99%	JD 515	Career Henan Chemical Co

2-Bromo-2'-fluoroacetophenone
655-15-2
US $8.00-3.00 / KG
99%
Henan Fengda Chemical Co., Ltd

2-Bromo-1-(2-fluorophenyl)ethanone
655-15-2
US $0.00 / KG
97.4%
Honest Joy Holdings Limited

2-Bromo-2'-fluoroacetophenone
655-15-2
US $7.00 / KG
99%
Career Henan Chemical Co

2-Bromo-2'-fluoroacetophenone Spectrum

2-Bromo-2'-fluoroacetophenone(655-15-2)¹HNMR

655-15-2(2-Bromo-2'-fluoroacetophenone)Related Search:

3-Nitroacetophenone Calcium bromide Ethidium bromide 4'-(Trifluoromethyl)acetophenone 4-Nitroacetophenone

1-(2,6-Difluorophenyl)ethan-1-one 2',4'-Difluoroacetophenone Trifluoroacetophenone Acetophenone 2',4'-Dichloroacetophenone

2-Fluorobenzyl cyanide 2'-Fluoroacetophenone Sodium bromate 4-Fluoroacetophenone 3'-Fluoroacetophenone

2-Bromoacetophenone 2-Bromo-2'-nitroacetophenone 4'-Bromoacetophenone

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BUTTPARK 35\01-51 2-BROMO-2'-DIFLUOROACETOPHENONE Ethanone, 2-bromo-1-(2-fluorophenyl)- (9CI) 2-Fluorophenacylbromide98% 2-FLUOROPHENACYL BROMIDE 2-Bromo-1-(2-fluoro-phenyl)-ethanone 2-Bromo-2'-fluoroacetophenone, 2-Bromo-1-(2-fluorophenyl)ethan-1-one 1-BroMo-2'-fluoroacetophenone o-Fluorophenacyl BroMide α-BroMo-2-fluoroacetophenone ω-BroMo-2 2-Bromo-2'-fluoroacetophentone 2-Fluorophenacyl bromide Vonoprazan Fumarate Impurity 88 TAK438 Impurity 83 Ethanone,2-bromo-1-(2-fluorophenyl)- 2-Bromo-2'-Fluoroacetophenone,>98% Vonolazan fumarate impurity Vonoprazan-030 Vonoprazan Impurity 83 2-Bromo-2'-fluoroacetophenone ISO 9001：2015 REACH 2-bromo-1-(2-fluorophenyl)ethan-1-one 2-Bromo-2'-fluoroacetophenone 2-BROMO-2'-FLUOROACETOPHENONE 98% 2-Bromo-2'-fluoroacetophenone 655-15-2 Aromatics ACETYLHALIDE Ketone