VINBLASTINE
- CAS No.
- 865-21-4
- Chemical Name:
- VINBLASTINE
- Synonyms
- Rozevin;VINBLASTINE;Vincoblastine;Vincaleucoblastin;Vinblastine (7CI);Vincaleucoblastine;VINBLASTINE 94% BP98;VINBLASTINE SULFATE(RG);Vincristine EP Impurity H;Vinblastine, Vincaleukoblastine
- CBNumber:
- CB8201955
- Molecular Formula:
- C46H58N4O9
- Molecular Weight:
- 810.99
- MDL Number:
- MFCD05662370
- MOL File:
- 865-21-4.mol
| Melting point | 211-216° |
|---|---|
| alpha | D23 -32° (c = 0.88 in methanol) |
| Boiling point | 755.65°C (rough estimate) |
| Density | 1.1325 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform, Dichloromethane, Dimethyl Sulfoxide, Methanol |
| form | Solid |
| pka | 5.4, 7.4(at 25℃) |
| color | Yellow |
| FDA UNII | 5V9KLZ54CY |
| ATC code | L01CA01 |
| EPA Substance Registry System | Vinblastine (865-21-4) |
SAFETY
Risk and Safety Statements
| RIDADR | 1544 |
|---|---|
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Toxicity | LD50 intraperitoneal in mouse: 3120ug/kg |
VINBLASTINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 301104 | Vinblastine | 865-21-4 | 20mg | $320 | 2021-12-16 | Buy |
| ApexBio Technology | N2256 | vinblastine | 865-21-4 | 50mg | $315 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004590 | VINBLASTINE 95.00% | 865-21-4 | 100MG | $927.76 | 2021-12-16 | Buy |
| AK Scientific | Q943 | Vinblastine | 865-21-4 | 10mg | $60 | 2021-12-16 | Buy |
| ApexBio Technology | N2256 | vinblastine | 865-21-4 | 10mg | $96 | 2021-12-16 | Buy |
VINBLASTINE Chemical Properties,Uses,Production
Description
An alkaloid derived from the periwinkle, Catharanthus roseus (formerly Vinca rosea) used as an antitumor drug in the treatment of Hodgkins lymphoma and other cancers. It binds to the microtubule subunit, tubulin, at a site distinct from that of colchicine and podophyllotoxin. This binding is reversible, temperature dependent and rapid, and results in large tubulin aggregates of highly ordered structure (vinblastine paracrystals).
Physical properties
Appearance: needlelike crystals were produced when recrystallized by methanol. Solubility: soluble in chloroform, acetone, and ethanol. Melting point: 211– 216?°C.?Sulfate melting point of vinblastine is 284–285?°C; hydrochloric acid melting point of vinblastine is 244–246?°C (decomposes). Specific optical rotation: +42°.
Originator
Velban ,Lilly ,US ,1961
Uses
Vinblastine is used for severe lymphoblastic leukemia, Hodgkin’s disease, nonHodgkin’s lymphoma, neuroblastoma, sarcoma, and other cancerous diseases.
Uses
Labelled Vinblastine (V314000). Antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. An antineoplastic.
Indications
It was recorded in the Pharmacopoeia of the People’s Republic of China (2015), the
British Pharmacopoeia (2017), the United States Pharmacopeia (40), the Japanese
Pharmacopoeia (17th ed.), the European Pharmacopoeia (9th ed.), and The
International Pharmacopoeia (5th ed.).
Vinblastine sulfate injection is used as the first-line therapy to treat Hodgkin
lymphoma, lymphocytic leukemia, testis tumor, and choriocarcinoma intravenously
in clinical practice generally according to ABVD methods (Adriamycin, bleomycin,
vinblastine, and dacarbazine).
Manufacturing Process
According to US Patent 3,225,030, 1,500 grams of dried ground plant of Vinca
rosea were intimately mixed with 1,000 ml of a 2% tartaric acid solution, and
the mixture was extracted with three 9-liter portions of benzene. The benzene
extracts were combined and were concentrated in vacuo to about 1,500 ml.
The concentrate was mixed with 1 liter of 2% tartaric acid and the mixture
was steam-distilled under reduced pressure until all of the benzene had
distilled over. The insoluble residue was dissolved in hot methanol, a second
1-liter portion of 2% tartaric acid solution was added, and the mixture was
steam-distilled under reduced pressure until all of the methanol had distilled.
The undistilled aqueous tartaric acid solution was extracted with three 1-liter
portions of ethylene dichloride, and was then brought to a pH of about 8.5 to
9.5 by the addition of 28% aqueous ammonium hydroxide. The ammoniacal
solution was extracted with three 1-liter portions of ethylene dichloride; the
ethylene dichloride extracts were combined, were dried, and were evaporated
in vacuo, yielding a residue of 3.35 grams of a light-brown powder.
1 1/2 grams of the residue were dissolved in 10 ml of benzene, and the
solution was passed over a chromatographic adsorption column containing 50
grams of alumina (Alcoa activated alumina, Grade F-20) which had previously
been shaken for about 20 minutes with a mixture of 100 ml of benzene
containing 1.5 ml of 10% acetic acid.
The column was developed by washing it with 2,100 ml of benzene. The
column was then washed sequentially with 300 ml of benzene-chloroform
solvent (95:5 by volume) and 800 milliliters of benzene-chloroform solvent
(75:25) to remove indeterminate impurities. The leurosine was eluted from
the alumina by passing over the column 900 ml of benzene chloroform solvent
(50:50).
The eluate was evaporated to dryness in vacuo, leaving an amorphous residue
of 113 mg of leurosine. The residue was treated with a few ml of methanol in
which it quickly dissolved, but from which leurosine quickly precipitated in
crystalline form. Because of the affinity of leurosine for water, and the
presence of traces of water in the solvents, the leurosine was obtained in the
form of its octahydrate. Although the material as obtained was substantially pure, it was further purified by recrystallizing it from hot methanol solution.
The hydrated leurosine obtained decomposed at about 200° to 205°C.
Further elution of the above chromatographic column with a 50:50 benzene-
chloroform solvent mixture or with a 25:75 benzene-chloroform solvent
mixture serves to elute vincaleukoblastine. Vincaleukoblastine also occurs in
the latter fractions containing leurosine. Vincaleukoblastine is obtained from
vincaleukoblastine-containing fractions by evaporation to dryness, either of a
filtrate from which leurosine has previously been isolated, or from a
chromatographic eluate fraction. The resulting residue is dissolved in ethanol
and 286 ethanolic sulfuric acid is added until the pH is lowered to about 4.
The solution is seeded with crystals of vincaleukoblastine sulfate and is chilled
for about 24 hours. Vincaleukoblastine sulfate, if present, precipitates during
this period and can be separated by filtration. Vincaleukoblastine sulfate melts
at about 284° to 285°C.
brand name
Velban (Lilly).
Therapeutic Function
Cancer chemotherapy
Mechanism of action
Vinblastine suppresses cell growth during metaphase, affects amino acid metabolism, in particular at the level of including glutamine acid into the citric acid cycle and preventing it from transformation into urea, and it also inhibits protein and nucleic acid synthesis.
Pharmacokinetics
Leukopenia is the dose-limiting side effect, and dose reductions are warranted in patients with serum bilirubin levels greater than 3 mg/dL. The drug-related impact on erythrocyte and thrombocyte levels usually is insignificant. Like vincristine, it is administered as an IV bolus or infusion. The initial elimination half-life of 3.7 minutes is similar to vincristine, but the 24.8-hour terminal half-life is significantly shorter.
Clinical Use
In addition to the hematologic indications that it shares with vincristine, vinblastine sulfate has found utility in the treatment of advanced testicular carcinoma (often in combination with bleomycin), advanced mycosis fungoides, Kaposi's sarcoma, and histiocytosis X.
VINBLASTINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
View Lastest Price from VINBLASTINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-13 | Vinblastine
865-21-4
|
US $110.00 / kg | 1kg | 99% | 100MT | Hebei baicao biology science and technology co., ltd | |
 |
2021-07-13 | Vinblastine
865-21-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-09 | Vinblastine
865-21-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Vinblastine
865-21-4
- US $110.00 / kg
- 99%
- Hebei baicao biology science and technology co., ltd
-
- Vinblastine
865-21-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Vinblastine
865-21-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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