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(R)-BEL

(R)-BEL Structure
(R)-BEL structure
CAS No.
478288-90-3
Chemical Name:
(R)-BEL
Synonyms
(R)-BEL;(R)-BROMOENOL LACTONE;(R) Bromoenol lactone,(R)Bromoenol lactone;(3R,6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one;6E-(BROMOMETHYLENE)TETRAHYDRO-3R-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE;2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (3R,6E)-
CBNumber:
CB8215769
Molecular Formula:
C16H13BrO2
Molecular Weight:
317.18
MDL Number:
MFCD08062190
MOL File:
478288-90-3.mol
Last updated:2023-05-21 10:59:17
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(R)-BEL Properties

Boiling point 467.0±45.0 °C(Predicted)
Density 1.538±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): .05 mg/ml

(R)-BEL price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10006800 (R)-Bromoenol lactone ≥98% 478288-90-3 500μg $32 2024-03-01 Buy
Cayman Chemical 10006800 (R)-Bromoenol lactone ≥98% 478288-90-3 1mg $57 2024-03-01 Buy
Cayman Chemical 10006800 (R)-Bromoenol lactone ≥98% 478288-90-3 5mg $230 2024-03-01 Buy
Cayman Chemical 10006800 (R)-Bromoenol lactone ≥98% 478288-90-3 10mg $365 2024-03-01 Buy
American Custom Chemicals Corporation HCH0105431 6E-(BROMOETHYLENE)TETRAHYDRO-3R-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE 95.00% 478288-90-3 5MG $503.38 2021-12-16 Buy
Product number Packaging Price Buy
10006800 500μg $32 Buy
10006800 1mg $57 Buy
10006800 5mg $230 Buy
10006800 10mg $365 Buy
HCH0105431 5MG $503.38 Buy

(R)-BEL Chemical Properties,Uses,Production

Description

The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.1 The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 μM.2 (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 μM.

References

1. Balsinde, J., Balboa, M.A., Insel, P.A., et al. Regulation and inhibition of phospholipase A2 Annu. Rev. Pharmacol. Toxicol. 39,175-189(1999).
2. Jenkins, C.M., Han, X., Mancuso, D.J., et al. Identification of calcium-independent phospholipase A2 (iPLA2)β, and not iPLA2γ, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells J. Biol. Chem. 277(36),32807-32814(2002).

(R)-BEL Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-BEL Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14059 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
RD International Technology Co., Limited 18988968278 sales@ubiochem.com China 9146 58
Supplier Advantage
BOC Sciences 65
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58

478288-90-3((R)-BEL)Related Search:

Ethyl 1-naphthaleneacetate VINYL PHENYL ACETATE (R)-BEL Methyl naphthalene-1-acetate BROMOENOL LACTONE
(R)-BEL (R)-BROMOENOL LACTONE 6E-(BROMOMETHYLENE)TETRAHYDRO-3R-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE (3R,6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one (R) Bromoenol lactone,(R)Bromoenol lactone 2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (3R,6E)- 478288-90-3