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NORTRIPTYLINE HYDROCHLORIDE

CAS No.
894-71-3
Chemical Name:
NORTRIPTYLINE HYDROCHLORIDE
Synonyms
Vividyl;Acetexa;pamelor;Sensival;Norzepine;nortrilen;Norfenazin;aventylallegron;NORTRIPTYLINE HCL;Desitriptyline HCl
CBNumber:
CB8218917
Molecular Formula:
C19H22ClN
Molecular Weight:
299.84
MDL Number:
MFCD00058024
MOL File:
894-71-3.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:15

NORTRIPTYLINE HYDROCHLORIDE Properties

Melting point 217-220?C
Flash point 9℃
storage temp. 2-8°C
solubility ethanol: 100 mg/mL
form powder
color white to off-white
λmax 237nm(H2O)(lit.)
Merck 14,6715
NCI Dictionary of Cancer Terms Pamelor
FDA UNII 00FN6IH15D

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn,T,F
Risk Statements  22-36/38-23/25-11-39/23/24/25-23/24/25
Safety Statements  22-36-45-24-16-7-36/37
RIDADR  UN 1230 3/PG 2
WGK Germany  3
RTECS  HP0175000
HS Code  2921490002
Toxicity LD50 oral in rat: 405mg/kg

NORTRIPTYLINE HYDROCHLORIDE price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR3216 Nortriptyline Hydrochloride pharmaceutical secondary standard, certified reference material 894-71-3 500MG $230 2024-03-01 Buy
Sigma-Aldrich N-907 Nortriptyline hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 894-71-3 1mL $27.7 2024-03-01 Buy
Sigma-Aldrich N7261 Nortriptyline hydrochloride ≥98% (TLC), powder 894-71-3 10g $80.2 2024-03-01 Buy
Sigma-Aldrich 1474005 Nortriptyline hydrochloride United States Pharmacopeia (USP) Reference Standard 894-71-3 200mg $436 2024-03-01 Buy
TCI Chemical N0957 Nortriptyline Hydrochloride >98.0%(HPLC)(T) 894-71-3 5g $34 2024-03-01 Buy
Product number Packaging Price Buy
PHR3216 500MG $230 Buy
N-907 1mL $27.7 Buy
N7261 10g $80.2 Buy
1474005 200mg $436 Buy
N0957 5g $34 Buy

NORTRIPTYLINE HYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Originator

Aventyl,Lilly,UK,1963

Uses

Nortriptyline Hydrochloride (Amitriptyline EP Impurity C) is a tricyclic antidepressant.

Uses

Monoamine reuptake inhibitor; tricyclic antidepressant.

Definition

ChEBI: Nortriptyline hydrochloride is an organic tricyclic compound. It has a role as a geroprotector.

Manufacturing Process

A mixture of 114.5 g of 5-(3-chloropropylidene)dibenzo[a,d]cyclohepta[1,4] diene, 75 ml of benzene, and about 400 ml of methylamine is heated in an autoclave at 120°C for six hours. The excess methylamine is distilled from the reaction mixture under vacuum and the residue is stirred with 300 ml of water. Acidification of the mixture with hydrochloric acid causes the separation of the hydrochloride of 5-(3-methylaminopropylidene)dibenzo[a,d] cyclohepta[1,4]diene. The product is collected by filtration and is purified by recrystallization from a mixture of absolute ethanol and ethyl acetate. MP 210°C to 212°C.

brand name

Aventyl Hydrochloride (Lilly); Aventyl Hydrochloride (Ranbaxy); Pamelor (Tyco).

Therapeutic Function

Antidepressant

General Description

Pertinent biological and chemical properties for nortriptyline,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)Nmethyl-1-propanamine hydrochloride, 5-(3-methyl-aminopropylidene)-10,11-hydro-5H-dibenzo[a,d] cycloheptene hydrochloride(Aventyl, Pamelor), are given previously in thediscussion of amitriptyline. Metabolic inactivation and eliminationare like those of amitriptyline. Nortriptyline is a selectiveNE transporter (NET) inhibitor.

Biological Activity

ki: 3.4 nm: blocks the norepinephrine transporter.ki: 161 nm: inhibits the serotonin transporter.nortriptyline, a dibenzocycloheptene-derivative tricyclic antidepressant, inhibits norepinephrine and serotonin transporters, which is used for short-term treatment of various forms of depression, including major depression, dysthymia, and atypical depressions. nortriptyline suppresses the norepinephrine presynaptic receptors, thus inhibiting the reuptake of this neurotransmitter and increasing the concentration in the synaptic cleft in the central nervous system.norepinephrine transporter is responsible for the sodium-chloride (na+/cl-) -dependent reuptake of extracellular norepinephrine. serotonin transporter transports serotonin from the synaptic cleft to the presynaptic neuron.

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 3.4 nM) than the serotonin transporter (Ki = 161 nM). 5-HT2 serotonin receptor antagonist.

in vitro

nortriptyline dose-dependently dampened the spontaneous migration of human polymorphonuclear cells (pmn) at the highest concentrations (10-4 and 10-5 m). nortriptyline decreased the motility of the cells at 10-4m. chemotaxis of pmn triggered by 10-10m n-formyl-l-methionil-l-leucyl-l-phenylalanine (fmlp) was blocked by nortriptyline in a dose-dependent fashion [1].

in vivo

rats and mice were injected intraperitoneally with nortriptyline at the dose of 50, 25, 12.5 mg/kg. after 2 hours of the last injection, nortriptyline inducted little or no inhibition of the 4, α-dimethyl-meta-tyramine (h 77/77) induced depletion in a dose of 25 + 12.5 mg/kg. however, there was a partial blockade, evoked by nortriptyline in a dose of 50 + 25 mg/kg, of the h 77/77 elicited depletion in the noradrenaline nerve terminals in all the rats studied. additionally, nortriptyline also proved to be active in the brain, however, its activity was low [2].

References

[1]. sacerdote, p., bianchi, m., & panerai, a. chlorimipramine and nortriptyline but not fluoxetine and fluvoxamine inhibit human polymorphonuclear cell chemotaxis in vitro. general pharmacology: the vascular system. 1994; 25(3): 409-412.
[2]. carlsson, a., corrodi, h., fuxe, k., & hkfelt, t. effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4, α-dimethyl-meta-tyramine. european journal of pharmacology.1969; 5(4): 367-373.

NORTRIPTYLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 236)Suppliers
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Hangzhou MolCore BioPharmatech Co.,Ltd.
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View Lastest Price from NORTRIPTYLINE HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NORTRIPTYLINE HCL(USP)(COMING SOON)(P) USP/EP/BP pictures 2021-07-27 NORTRIPTYLINE HCL(USP)(COMING SOON)(P) USP/EP/BP
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
NORTRIPTYLINE HYDROCHLORIDE pictures 2019-12-25 NORTRIPTYLINE HYDROCHLORIDE
894-71-3
US $1.00 / g 1g 99% 1000KGS Career Henan Chemical Co

NORTRIPTYLINE HYDROCHLORIDE Spectrum

Nortriptyline Hydrochloride (200 mg) Nortriptyline HCl, 1.0 mg/mL as free base Norzepine Sensival Vividyl NORTRIPTYLINE HCL(P) Norfenazin Nortriptyline hydrochloride solution Nortriptyline for system suitability 1-Propanamine, 3-(10,11-dihydro-5H-dibenzoa,dcyclohepten-5-ylidene)-N-methyl-, hydrochloride NORTRIPTYLINEHYDROCHLORIDE,USP NORTRIPTYLINE HCL USP Nortriptyline solution hydrochloride 3-(10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5-ylidene)-n-methyl-1-propanamin 5-(3-(methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)dienehydrochloride NORTRIPTYLINE HYDROCHLORIDE NORTRIPTYLINE HCL 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methylpropylamine hydrochloride 3-(10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N-methyl-1-propanamine·hydrochloride Nortrityline Hydrochloride (2)10,11-Dihydro-N-methyl-5H-dibenzo[A,D]cycloheptene-.delta.5.gamma.-propylamine, hydrochloride 5-[(3-(Methylamino)propylidene]-10,11-dihydro-5H-dibenzo[A,D]cycloheptene hydrochloride 5-[3-(Methylamino)propylidene]dibenzo[A,D]cyclohepta[1,5]diene hydrochloride 5H-Dibenzo[A,D]cycloheptene-.delta.(sup5),.gamma.-propylamine, 10-11-dihydro-N-methyl-, hydrochloride 5H-Dibenzo[A,D]cycloheptene-.delta.5,.gamma.-propylamine, 10,11-dihydro-N-methyl-, hydrochloride Acetexa Noramitriptyline hydrochloride nortriptyline hydrochloride methanol*solution 5-(3-methylaminopropylidene)-10,11-dihydro-5h-dibenzo(a,d)cycloheptenehydroc 5h-dibenzo(a,d)cycloheptene-delta(sup5),gamma-propylamine,10-11-dihydro-n-met aventylallegron aventylhydrochloride desmethylamitriptylinehydrochloride nortrilen pamelor AMITRIPTYLINE HYDROCHLORIDE IMP C 3-(10, 11-DIHYDRO-5H-DIBENZO[A,D]-CYCLOHEPTEN-5-YLIDENE)-N-METHYL-1-PROPANAMINE HYDROCHLORIDE Amitriptyline hydrochloride impurity C Amitriptyline EP Impurity C HCl Nortriptyline hydrochloride CRS Nortriptyline Hydrochloride > Nortriptyline for system suitability CRS Nortriptyline HCl (Amitriptyline EP Impurity C HCl) Amitriptyline EP Impurity C HCl (Nortriptyline HCl) Desitriptyline HCl ELF-101 hydrochloride EN-7048 hydrochloride 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine hydrochloride 10,11-Dihydro-5-(N-methyl-3-aminopropylidene)-5H-dibenzo[a,d]cycloheptene Hydrochloride NORTRIPTYLINE HCL(USP)(COMING SOON)(P) USP/EP/BP NORTRIPTYLINE HYDROCHLORIDE USP/EP/BP Nortriptyline HydrochlorideQ: What is Nortriptyline Hydrochloride Q: What is the CAS Number of Nortriptyline Hydrochloride Q: What is the storage condition of Nortriptyline Hydrochloride Q: What are the applications of Nortriptyline Hydrochloride Amitriptyline Impurity 3 Nortriptyline Hydrochloride (1474005) N-Desmethyl Amitriptyline HCl Amitriptyline Hydrochloride EP Impurity C as Hydrochloride 894-71-3 C19H21NHCl