ChemicalBook >> CAS DataBase List >>ARRY-424704, ARRY-704
ARRY-424704, ARRY-704
- CAS No.
- 869357-68-6
- Chemical Name:
- ARRY-424704, ARRY-704
- Synonyms
- CS-396;ARRY704;AZD8330;ARRY-704;ARRY424704;ARRY-424704;AZD8330 (ARRY704;AZD8330 AZD-8330;AZD8330(ARRY-424704;ARRY-424704, ARRY-704
- CBNumber:
- CB82512518
- Molecular Formula:
- C16H17FIN3O4
- Molecular Weight:
- 461.23
- MDL Number:
- MFCD18384989
- MOL File:
- 869357-68-6.mol
Last updated:2023-06-08 09:02:00
| Density | 1.732 |
|---|---|
| storage temp. | Store at -20°C |
| solubility | ≥23.05 mg/mL in DMSO; insoluble in H2O; ≥46.1 mg/mL in EtOH |
| form | solid |
| pka | 14.31±0.10(Predicted) |
| FDA UNII | G4990BOZ66 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H372-H301 | |||||||||
| Precautionary statements | P260-P264-P270-P314-P501-P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
ARRY-424704, ARRY-704 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11588 | AZD 8330 ≥98% | 869357-68-6 | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 11588 | AZD 8330 ≥98% | 869357-68-6 | 5mg | $194 | 2024-03-01 | Buy |
| Cayman Chemical | 11588 | AZD 8330 ≥98% | 869357-68-6 | 10mg | $270 | 2024-03-01 | Buy |
| Cayman Chemical | 11588 | AZD 8330 ≥98% | 869357-68-6 | 50mg | $1041 | 2024-03-01 | Buy |
| Usbiological | 474069 | AZD 8330 | 869357-68-6 | 100mg | $2229 | 2021-12-16 | Buy |
ARRY-424704, ARRY-704 Chemical Properties,Uses,Production
Description
AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells. AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.
Uses
AZD8330 is an orally active and selective MEK inhibitor.
Definition
ChEBI: 2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.
target
ERK phosphorylation
References
1. feng k, wang c, zhou h, yang j, dong l, zhou k, et al. [effect of erk1/2 inhibitor azd8330 on human burkitt's lymphoma cell line raji cells and its mechanism]. zhonghua xue ye xue za zhi 2015,36:148-152.2. cohen rb, aamdal s, nyakas m, cavallin m, green d, learoyd m, et al. a phase i dose-finding, safety and tolerability study of azd8330 in patients with advanced malignancies. eur j cancer 2013,49:1521-1529.
ARRY-424704, ARRY-704 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 113)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9320 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
View Lastest Price from ARRY-424704, ARRY-704 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-17 | ARRY-424704, ARRY-704
869357-68-6
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2022-10-14 | ARRY-424704, ARRY-704
869357-68-6
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-10-22 | ARRY-424704, ARRY-704
869357-68-6
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- ARRY-424704, ARRY-704
869357-68-6
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- ARRY-424704, ARRY-704
869357-68-6
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- ARRY-424704, ARRY-704
869357-68-6
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
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ARRY-424704, ARRY-704
AZD8330
2-(2-Fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
ARRY424704
ARRY-424704
ARRY704
ARRY-704
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ARRY-424704, ARRY-704
AZD8330
AZD8330;ARRY-424704; ARRY424704;ARRY704; AZD8330
2-((2-Fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-
CS-396
AZD8330(ARRY-424704
ARRY-424704; ARRY-704; AZD-8330; ARRY424704; ARRY704; AZD 8330
3-Pyridinecarboxamide, 2-[(2-fluoro-4-iodophenyl)amino]-1,6-dihydro-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-
ARRY-424704, ARRY-704 ISO 9001：2015 REACH
AZD8330 (ARRY704
AZD8330 AZD-8330
869357-68-6
C16H17FIN3O4
Inhibitors
MAPK