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BMS-794833

BMS-794833 structure

CAS No.: 1174046-72-0

Chemical Name:: BMS-794833

Synonyms: CS-531;CS-1738;MS-794833;BMS-794833;BMS-794833 USP/EP/BP;BMS-794833 BMS794833;PDYXPCKITKHFOZ-UHFFFAOYSA-N;N-[4-(2-AMINO-3-CHLOROPYRIDIN-4-YL)OXY-3-FLUOROPHENYL]-5-(4-FLUOROPHENYL)-4-OXO-1H-PYRIDINE-3-CARBOXAMIDE;N-[4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide;N-[4-((2-Amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

CBNumber:: CB02538914

Molecular Formula:: C23H15ClF2N4O3

Molecular Weight:: 468.84

MDL Number:

MOL File:: 1174046-72-0.mol

Last updated:2023-06-08 09:03:09

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BMS-794833 Properties

Boiling point	637.2±55.0 °C(Predicted)
Density	1.508
storage temp.	Store at -20°C
solubility	≥23.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form	solid
pka	8.79±0.69(Predicted)
FDA UNII	SAY8KVM4HU

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

NFPA 704

	0
2		0

BMS-794833 price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	26180	BMS 794833	1174046-72-0	1mg	$37	2024-03-01	Buy
Cayman Chemical	26180	BMS 794833	1174046-72-0	25mg	$618	2024-03-01	Buy
Cayman Chemical	26180	BMS 794833	1174046-72-0	5mg	$161	2024-03-01	Buy
Cayman Chemical	26180	BMS 794833	1174046-72-0	10mg	$301	2024-03-01	Buy
TRC	B596010	BMS794833	1174046-72-0	10mg	$330	2021-12-16	Buy

Product number	Packaging	Price	Buy
26180	1mg	$37	Buy
26180	25mg	$618	Buy
26180	5mg	$161	Buy
26180	10mg	$301	Buy
B596010	10mg	$330	Buy

BMS-794833 Chemical Properties,Uses,Production

Uses

BMS-794833 is a potent ATPcompetitive Met/VEGFR-2 kinase inhibitor and it also inhibits Ron (Met family),Axl and Flt-3 with IC50 values <3 nM.

Biological Activity

bms-794833 is a potent atp competitive, dual inhibitor of c-met and vegfr2 (ic50 = 1.7 nm and 15 nm, respectively). it also has inhibitory effect on ron, axl and flt3 (ic50 < 3 nm).c-met, also called met, is a membrane receptor that is essential for embryonic development and wound healing. vegfr are receptors for vascular endothelial growth factor and belong to receptor tyrosine kinases. it mediates in various cellular functions, including endothelial proliferation, migration, survival, tubular morphogenesis and sprouting. [1]bms794833 also inhibited gastric cancer cell line (gtl-16) that induced by c-met receptor, gtl-16, ic50 = 39 nm [1]. in human gastric tumor xenografts model, bm798433 exhibits > 50% tgi for at least one tumor doubling time without significant toxicity in 14 days. in u87 glioblastoma model, 25mg/kg of bms798433 exert complete tumor stasis. [1]

References

[1] 4-pyridinone compounds and their use of cancer, borzilleri et al, united states patent application publication, pub no. : us 2012/0114643 a1, pub.date: may 10, 2012.

BMS-794833 synthesis

Synthesis of BMS-794833 from 3-Pyridinecarboxamide, N-[4-[[3-chloro-2-[(diphenylmethylene)amino]-4-pyridinyl]oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo-

BMS-794833 Preparation Products And Raw materials

Raw materials

3-Pyridinecarboxamide, N-[4-[[3-chloro-2-[(diphenylmethylene)amino]-4-pyridinyl]oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo-

Preparation Products

BMS-794833 Suppliers

Global( 102)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58

View Lastest Price from BMS-794833 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-23	BMS-794833 1174046-72-0	US $1.00 / g	100g	98%min	G/KG/T	Career Henan Chemical Co

BMS-794833
1174046-72-0
US $1.00 / g
98%min
Career Henan Chemical Co

BMS-794833 Spectrum

BMS-794833(1174046-72-0)¹HNMR

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BMS-794833 3-PyridinecarboxaMide, N-[4-[(2-aMino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo- N-[4-((2-Amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide N-[4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide MS-794833 N-[4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide MS-794833 N-[4-(2-AMINO-3-CHLOROPYRIDIN-4-YL)OXY-3-FLUOROPHENYL]-5-(4-FLUOROPHENYL)-4-OXO-1H-PYRIDINE-3-CARBOXAMIDE PDYXPCKITKHFOZ-UHFFFAOYSA-N CS-531 CS-1738 BMS-794833 USP/EP/BP BMS-794833 BMS794833 1174046-72-0 C23H15ClF2N4O3 Inhibitors