ChemicalBook >> CAS DataBase List >>5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
- CAS No.
- 218457-67-1
- Chemical Name:
- 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
- Synonyms
- Limantrafin;BUTTPARK 96\12-100;6-(4-tert-butylphenoxy)-3-pyridinamine;5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE;6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%;6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine;3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-;pathway,CB103,inhibit,Inhibitor,Notch,CB-103,signaling,leukemia,CB 103
- CBNumber:
- CB8254830
- Molecular Formula:
- C15H18N2O
- Molecular Weight:
- 242.32
- MDL Number:
- MFCD00052647
- MOL File:
- 218457-67-1.mol
Last updated:2023-09-04 16:42:00
| Melting point | 89-90 |
|---|---|
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (>30 mg/ml) |
| form | solid |
| color | Off-white to pale orange |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 218457-67-1(CAS DataBase Reference) |
| FDA UNII | Q5BB91JL0V |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P271-P261-P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3460 | CB-103 ≥97% (HPLC) | 218457-67-1 | 10MG | $64.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3460 | CB-103 ≥97% (HPLC) | 218457-67-1 | 50MG | $261 | 2024-03-01 | Buy |
| TRC | A594853 | 5-Amino-2-(4-tert-butylphenoxy)pyridine | 218457-67-1 | 500mg | $90 | 2021-12-16 | Buy |
| TRC | A594853 | 5-Amino-2-(4-tert-butylphenoxy)pyridine | 218457-67-1 | 100mg | $60 | 2021-12-16 | Buy |
| Apolloscientific | OR8051 | 6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97% | 218457-67-1 | 1g | $105 | 2021-12-16 | Buy |
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Chemical Properties,Uses,Production
Description
CB-103 (218457-67-1) is an orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 μM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines.? CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.
References
Lehal et al. (2020), Pharmacological disruption of the Notch transcription factor complex; Proc. Natl. Acad. Sci. USA, 117 16292
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 87)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
218457-67-1(5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE)Related Search:
6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%
6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE
BUTTPARK 96\12-100
3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-
6-(4-tert-butylphenoxy)-3-pyridinamine
pathway,CB103,inhibit,Inhibitor,Notch,CB-103,signaling,leukemia,CB 103
6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine
Limantrafin
218457-67-1
C15H18N2O
ARYL AMINE