PF-01367338
- CAS No.
- 459868-92-9
- Chemical Name:
- PF-01367338
- Synonyms
- CS-47;AG14699;Rubraca;AG-014699;PF-01367338;Rucaparib(AG-01);Rucaparib D4 HCl;AG014699 phosphate;Rucaparib phosphate;PF-01367338/AG14699
- CBNumber:
- CB82515928
- Molecular Formula:
- C19H21FN3O5P
- Molecular Weight:
- 421.37
- MDL Number:
- MFCD17010269
- MOL File:
- 459868-92-9.mol
- MSDS File:
- SDS
| Melting point | >173°C (dec.) |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | Yellow solid. |
| color | Yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| FDA UNII | H3M9955244 |
| NCI Dictionary of Cancer Terms | AG014699 |
| NCI Drug Dictionary | Rubraca |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS02 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H226 |
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235 |
PF-01367338 price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11570 | Rucaparib (phosphate) ≥98% | 459868-92-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 11570 | Rucaparib (phosphate) ≥98% | 459868-92-9 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 11570 | Rucaparib (phosphate) ≥98% | 459868-92-9 | 10mg | $243 | 2024-03-01 | Buy |
| TRC | A425500 | AG14699 | 459868-92-9 | 10mg | $140 | 2021-12-16 | Buy |
| TRC | A425500 | AG14699 | 459868-92-9 | 5mg | $90 | 2021-12-16 | Buy |
PF-01367338 Chemical Properties,Uses,Production
Description
Rucaparib phosphate (459868-92-9) is a potent (Ki<5 nM) PARP1 inhibitor.1?Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2.2?Demonstrates antiproliferative effects in 26 out of 39 ovarian cancer cell lines.3?Synergizes with other anticancer agents such as topotecan, carboplatin, doxorubicin, paclitaxel,3 and temozolomide.4?Ameliorates the cardiotoxicity of doxorubicin.5?Recently approved for human use by the FDA.
Uses
PARP inhibitor oncolytic
References
1) Thomas?et al.?(2007),?Preclinical selection of a n novel poly(ADP-ribose) polymerase inhibitor for clinical trial; Mol. Cancer Ther.,?6?945 2) Drew?et al.?(2011),?Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2; J. Natl. Cancer Inst.,?103?334 3) Ihnen?et al.?(2013),?Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer; Mol. Cancer Ther.,?12?1002 4) Plummer?et al.?(2013),?A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation; Cancer Chemother. Pharmacol.,?71?1191 5) Ali?et al.?(2011),?The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice; Mol. Cancer Ther.,?10?2320
PF-01367338 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hangzhou Cyanochem Co., Ltd. | +86 17788583750 | sales@cyanochem.com | CHINA | 283 | 58 |
View Lastest Price from PF-01367338 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-10-10 | PF-01367338
459868-92-9
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-06 | Rucaparib
459868-92-9
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. | |
 |
2022-10-01 | Rucaparib phosphate;PF01367338 phosphate
459868-92-9
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- PF-01367338
459868-92-9
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Rucaparib
459868-92-9
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
-
- Rucaparib phosphate;PF01367338 phosphate
459868-92-9
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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