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ChemicalBook >> CAS DataBase List >>(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Structure
(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid structure
CAS No.
220352-36-3
Chemical Name:
(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid
Synonyms
(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid;Ticagrelor-22;Ticagerelor Impurity;Ticagrelor Related Compound 28;(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid;(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylicaci;Cyclopropanecarboxylic acid, 2-(3,4-difluorophenyl)-, (1R,2R)-;(1R-2R)-2-(3,4-DIFLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID CAS 220352-36-3;Ticagrelor impurity 33/(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid
CBNumber:
CB82599546
Molecular Formula:
C10H8F2O2
Molecular Weight:
198.17
MDL Number:
MFCD20639702
MOL File:
220352-36-3.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06
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(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Properties

Melting point 78 - 81°C
Boiling point 308.1±42.0 °C(Predicted)
Density 1.435±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
pka 4.53±0.10(Predicted)
form Solid
color Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2916200090

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D447015 (1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylicAcid 220352-36-3 100mg $185 2021-12-16 Buy
TRC D447015 (1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylicAcid 220352-36-3 500mg $460 2021-12-16 Buy
American Custom Chemicals Corporation CCH0032247 (1R,2R)-2-(3,4-DIFLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID 95.00% 220352-36-3 5MG $502.22 2021-12-16 Buy
Apolloscientific PC421187 (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylicacid 97% 220352-36-3 100mg $699 2021-12-16 Buy
AK Scientific 2834AH (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylicacid 220352-36-3 2.5g $1109 2021-12-16 Buy
Product number Packaging Price Buy
D447015 100mg $185 Buy
D447015 500mg $460 Buy
CCH0032247 5MG $502.22 Buy
PC421187 100mg $699 Buy
2834AH 2.5g $1109 Buy

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Chemical Properties,Uses,Production

Uses

(1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylic Acid is an intermediate used to prepare AZD6140 as an orally active reversible P2Y12 receptor antagonist for prevention of thrombosis. It is also used to synthesize triazolopyrimidine derivatives as P2T receptor antagonists.

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid synthesis

867-13-0
1006376-60-8
220352-36-3
Synthesis of (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid from Triethyl phosphonoacetate and (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Preparation Products And Raw materials

Raw materials

3,4-difluorocinnaMoyl chloride trans-3,4-Difluorocinnamic acid 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone 3,4-Difluorophenylboronic acid (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbonitrile
(1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate 3,4-DIFLUOROSTYRENE (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol 1,2-Difluoro-4-iodobenzene 1,2-Difluorobenzene
Cyclopropanecarboxylic acid 3,4-Difluorobenzaldehyde Triethyl phosphonoacetate

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Preparation Products

(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Suppliers

Global( 105)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 811 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
SIMAGCHEM CORP 		+86-13806087780 sale@simagchem.com China 17367 58
Hangzhou Cherry Pharmaceutical Technology Co.,ltd 		0571-81636070 info@cherrypharmatech.com CHINA 274 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9702 58
Supplier Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Hi-Tech Chemistry Corp 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Standardpharm Co. Ltd. 		58
career henan chemical co 		58
SIMAGCHEM CORP 		58
Hangzhou Cherry Pharmaceutical Technology Co.,ltd 		58
AFINE CHEMICALS LIMITED 		58
Finetech Industry Limited 		58

View Lastest Price from (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid pictures 2020-01-05 (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid
220352-36-3
 US $9.80 / KG 1g ≥99% 100kg Career Henan Chemical Co

220352-36-3((1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid)Related Search:

Ticagrelor iMpurity (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol Ticagrelor Related Compound 44 4-Chloro-2-propylsulfanyl-pyrimidine 1,2-Cyclopentanediol, 3-[7-aMino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyriMidin-3-yl]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)-
TRANSAMINE Ticagrelor Related Compound 3 (3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-2,2- 2-(((3aR,4S,6R,6aS)-6-(7-aMino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-2,2-diMethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol Ticagrelor Sulfone
(2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) (1R,2R,3S,5R)-3-(7-((1S,2R)-2-(3,4-difluorophenyl)cyclopropylaMino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol (3aS,4R,6S,6aR)-6-AMinotetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-ol
(1S,2S,3R,5S)-3-(7-hydroxy-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol AR-C 124910XX 2-[[(3aR,4S,6R,6aS)-6-(7-azanyl-5-propylsulfanyl-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy]ethanol

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(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Ticagrelor Related Compound 28 Ticagerelor Impurity Ticagrelor-22 Ticagrelor impurity 33/(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid Cyclopropanecarboxylic acid, 2-(3,4-difluorophenyl)-, (1R,2R)- (1R-2R)-2-(3,4-DIFLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID CAS 220352-36-3 (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylicaci 220352-36-3