ChemicalBook
Chinese Japanese Germany Korea

Binimetinib

Kinase inhibitor Mechanism of Action Pharmacokinetics
Binimetinib
Binimetinib structure
CAS No.
606143-89-9
Chemical Name:
Binimetinib
Synonyms
MEK162;CS-394;ARRY-162;ARRY 162;Binimetinib;ARRY-438162;MEK162, ARRY-162;MEK162(Binimetinib);MEK162 (ARRY-438162);Binimetinib (MEK-162)
CBNumber:
CB82604200
Molecular Formula:
C17H15BrF2N4O3
Formula Weight:
441.23
MOL File:
606143-89-9.mol

Binimetinib Properties

Density 
1.67
pka
14.20±0.10(Predicted)
FDA UNII
181R97MR71
NCI Dictionary of Cancer Terms
binimetinib
NCI Drug Dictionary
binimetinib

Binimetinib price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16996 Binimetinib ≥98% 606143-89-9 5mg $45 2021-03-22 Buy
Cayman Chemical 16996 Binimetinib ≥98% 606143-89-9 10mg $86 2021-03-22 Buy
Cayman Chemical 16996 Binimetinib ≥98% 606143-89-9 50mg $360 2021-03-22 Buy
Cayman Chemical 16996 Binimetinib ≥98% 606143-89-9 100mg $630 2021-03-22 Buy

Binimetinib Chemical Properties,Uses,Production

Kinase inhibitor

Binimetinib, also known as Mektovi, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor with potential antineoplastic activity.
Binimetinib, noncompetitive with ATP, binds to and inhibits the activity of MEK1/2. Inhibition of MEK1/2 prevents the activation of MEK1/2 dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling. This may eventually lead to an inhibition of tumor cell proliferation and an inhibition in production of various inflammatory cytokines including interleukin-1, -6 and tumor necrosis factor.

Mechanism of Action

Binimetinib is a reversible inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2 activity. MEK proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway. In vitro, binimetinib inhibited extracellular signal-related kinase (ERK) phosphorylation in cellfree assays as well as viability and MEK-dependent phosphorylation of BRAF-mutant human melanoma cell lines. Binimetinib also inhibited in vivo ERK phosphorylation and tumor growth in BRAF-mutant murine xenograft models.

Pharmacokinetics

The primary metabolic pathway is glucuronidation with UGT1A1 contributing up to 61% of the binimetinib metabolism. Other pathways of binimetinib metabolism include N-dealkylation, amide hydrolysis, and loss of ethane-diol from the side chain. The active metabolite M3 produced by CYP1A2 and CYP2C19 represents 8.6% of the binimetinib exposure. Following a single oral dose of 45 mg radiolabeled binimetinib, approximately 60% of the circulating radioactivity AUC in plasma was attributable to binimetinib.

Binimetinib Preparation Products And Raw materials

Raw materials

Preparation Products


Binimetinib Suppliers

Global( 139)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26725 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29969 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Jinan Carbotang Biotech Co.,Ltd.
+86 15866703830
figo.gao@foxmail.com CHINA 2709 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58

Related articles

  • What is Binimetinib?
  • Binimetinib is a kinase inhibitor. The chemical name is 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2hydroxyethoxy)- 1-methy....
  • Feb 21,2020

View Lastest Price from Binimetinib manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-13 Binimetinib
606143-89-9
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10 Binimetinib
606143-89-9
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06 Binimetinib
606143-89-9
US $1.00 / KG 1G 98% 100KG career henan chemical co

606143-89-9(Binimetinib)Related Search:


  • 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
  • MEK162 (ARRY-438162)
  • MEK162 (ARRY-162, ARRY-438162)
  • BiniMetinib (MEK162, ARRY-162, ARRY-438162)
  • 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-
  • 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide Binimetinib (MEK162, ARRY-162, ARRY-438162)
  • ARRY-438162 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
  • Binimetinib
  • MEK162
  • ARRY 162
  • ARRY-162
  • ARRY-438162
  • Binimetinib (MEK-162)
  • MEK162(Binimetinib)
  • BINIMETINIB, ARRY-438162
  • 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide
  • 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-car
  • MEK162, ARRY-162
  • CS-394
  • MEK162 (ARRY-438162,Binimetinib)
  • ARRY 162; ARRY 438162; MEK-162;BINIMETINIB;MEK-162; ARRY-162; ARRY-438162
  • Binimetinib,MEK162, ARRY-162
  • Binimetinib USP/EP/BP
  • Binimetinib(Free Base)
  • 606143-89-9
  • C17H15BrF2N4O3
  • Inhibitors
  • API
  • MAPK
Copyright 2017 © ChemicalBook. All rights reserved