5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol
![5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol Structure](CAS/20180703/GIF/383392-66-3.gif)
- CAS No.
- 383392-66-3
- Chemical Name:
- 5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol
- Synonyms
- UC-112;CS-2116;UC 112,UC112;5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol;5-((benzyloxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol;5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol;8-Quinolinol, 5-[(phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-
- CBNumber:
- CB83038521
- Molecular Formula:
- C22H24N2O2
- Molecular Weight:
- 348.44
- MDL Number:
- MFCD00469145
- MOL File:
- 383392-66-3.mol
5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 5251 | UC112 ≥98%(HPLC) | 383392-66-3 | 10 | $205 | 2021-12-16 | Buy |
| Tocris | 5251 | UC112 ≥98%(HPLC) | 383392-66-3 | 50 | $865 | 2021-12-16 | Buy |
| Usbiological | 257010 | UC 112 | 383392-66-3 | 10mg | $466 | 2021-12-16 | Buy |
| TRC | U130610 | UC112 | 383392-66-3 | 50mg | $820 | 2021-12-16 | Buy |
| TRC | U130610 | UC112 | 383392-66-3 | 10mg | $195 | 2021-12-16 | Buy |
5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol Chemical Properties,Uses,Production
Uses
UC 112 is a novel second mitochondria-derived activator of caspase mimetics as selective inhibitors of apoptosis protein inhibitors.
Definition
ChEBI: 5-(phenylmethoxymethyl)-7-(1-pyrrolidinylmethyl)-8-quinolinol is a hydroxyquinoline.
Biological Activity
uc-112[5-((benzyloxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol], is inhibitor of inhibitor of apoptosis protein (iap).[1]inhibitor of apoptosis protein (iap) family is overexpressed in most human cancer cells, but nearly isn’t expressed in adult differentiated tissues. inhibitor of apoptosis (iap) proteins are widely considered as promising drug-resistant tumors drug targets. [1,2]uc-112 strongly activates caspase-3/7 and caspase-9 activities, and selectively reduce surviving level at a concentration as low as 1 mm. coincubation of uc-112 with a known proteasome inhibitor z-leu-leu-leu-cho (mg-132) rescued survivin inhibition. as a single agent, uc-112 strongly inhibits tumor growth and reduces both x chromosomelinked iap and survivin levels in an a375 human melanoma xenograft model in vivo.[1]uc-112 inhibits tumor cell growth in several cancer cell lines in vitro and suppresses melanoma tumor growth in vivo. mechanistic studies indicated that uc-112 selectively inhibits survivin expression and induces strong cancer cell apoptosis. uc-112 could efficiently inhibit tumor cell proliferation by down regulating the level of iaps, especially survivin protein.[1,2]
storage
Store at +4°C
References
[1] wang j, li w. discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. j pharmacol exp ther. 2014 may;349(2):319-29.
[2] xiao m, wang j, lin z, etal. , design, synthesis and structure-activity relationship studies of novel survivin inhibitors with potent anti-proliferative properties. plos one. 2015 jun 12;10(6):e0129807.
5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol Preparation Products And Raw materials
Raw materials
Preparation Products
5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4986 | 55 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| Cckinase, Inc. | +1 (732)236-3202 | sales@cckinase.com | United States | 2738 | 58 |