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Brimonidine Tartrate

Ocular hypotensive drug Clinical Study Adverse reactions Precautions
Brimonidine Tartrate
Brimonidine Tartrate structure
CAS No.
70359-46-5
Chemical Name:
Brimonidine Tartrate
Synonyms
Alphagan;UK-14304-18;304 tartrate;AGN-190342-LF;UK 14,304 TARTRATE;AGN190342 tartrate;BRIMONIDINE TARTATE;BRIMONIDINE TARTRATE;Brimonidinne tartrate;Brimonidine tartarate
CBNumber:
CB8351621
Molecular Formula:
C15H16BrN5O6
Formula Weight:
442.22
MOL File:
70359-46-5.mol

Brimonidine Tartrate Properties

Melting point:
207-208°C (dec.)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
neat
InChIKey
QZHBYNSSDLTCRG-WUUYCOTASA-N
CAS DataBase Reference
70359-46-5(CAS DataBase Reference)
FDA UNII
4S9CL2DY2H
NCI Drug Dictionary
Alphagan
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P305+P351+P338
RIDADR  UN 2811 6.1 / PGIII
HS Code  29332900

Brimonidine Tartrate price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001658 Brimonidine tartrate European Pharmacopoeia (EP) Reference Standard 70359-46-5 y0001658 $190 2020-08-18 Buy
Sigma-Aldrich Y0001658 Brimonidine tartrate European Pharmacopoeia (EP) Reference Standard 70359-46-5 $190 2021-03-22 Buy
Cayman Chemical 15426 Brimonidine (tartrate) ≥98% 70359-46-5 10mg $45 2021-03-22 Buy
Cayman Chemical 15426 Brimonidine (tartrate) ≥98% 70359-46-5 25mg $62 2021-03-22 Buy
Cayman Chemical 15426 Brimonidine (tartrate) ≥98% 70359-46-5 50mg $90 2021-03-22 Buy

Brimonidine Tartrate Chemical Properties,Uses,Production

Ocular hypotensive drug

Brimonidine is a highly selective α2-receptor blocker, successfully developed by the US Company Allergan, which is an eye medication. It can reduce intraocular pressure (IOP). Brimonidine tartrate ophthalmic solution saling in the market is brimonidine tartrate form, which is a good IOP-lowering medication for chronic open-angle glaucoma and ocular hypertension treatment of patients, but also for argon laser IOP levels.
Brimonidine tartrate ophthalmic solution has a dual mechanism of action by reducing aqueous humor production and increasing the pigment layer of liquid scleral outflow therapeutic purposes. After dropping into the eye, the effect is rapid, and it can reach the peak when using up to 2h, and the effective time can maintain 12h. Blood can only detect traces of drugs. This product has first-pass metabolism in the liver, and metabolites excreted in the urine by the kidneys. Systemic absorption and distribution are not affected, and the elderly do not need dose adjustment.
 Brimonidine tartrate ophthalmic solution compared with other α-blockers, the fat-soluble is small, while it does not easy to pass through blood-brain barrier and does not produce sedation, hypotension and other similar clonidine central adverse reactions.
Brimonidine tartrate ophthalmic solution is highly selective for α2-adrenergic receptors, and α2/α1 ratio of receptor affinity is more than 1000 times. The effect of alpha 2 receptors can lead to lower intraocular pressure. And the role of the alpha 1 receptors can lead to vascular contraction, eyelid retraction or reduction and dilation of the pupil. Long term application of this product will not cause rapid desensitization.
In addition, compared with β-blockers, brimonidine tartrate eye drops for minor cardiovascular effects, it has no effect on lung function, so it is suitable for disabled patients β-blockers. Furthermore, when used alone β-blocker, it can not achieve therapeutic purposes, and you can simultaneously increase the FDA.
More information from ChemicalBook of Andy edited.

Clinical Study

This product can reduce intraocular pressure in glaucoma patients, only mild cardiovascular impact. Clinical trials showed that the drug with a 0.5% timolol considerable effect. Two drugs used alone, 2 times a day, one drop every time, the mean decrease in intraocular pressure and reach a peak, respectively: 0.79~1.01 kPa, 0.5% timolol is 0.8~0.88kPa. After the treatment of 12h, the mean decrease in intraocular pressure were: 0.49~0.67kPa and 0.79~0.88kPa.
Brimonidine tartrate ophthalmic solution is recommended for using three times a day program, and some clinical trials showed that 2 times a day, 3 times a day with no difference in efficacy.

Adverse reactions

10% to 30% of people may feel dry mouth, fatigue, ocular hyperemia, burning and tingling, headache, blurred vision, foreign body sensation in the eye, conjunctival follicles, ocular allergic reactions and eye pruritus .
There are 3%~9% of the patients had corneal staining (or ulcer, photophobia, eyelid erythema, eye soreness or pain, dry tears, eyelid edema, conjunctival edema, dizziness, blepharitis, eye irritation, conjunctiva, vision abnormalities, symptoms of upper respiratory tract, gastrointestinal symptoms, weakness, and muscle pain.
Less than 3% of the patients with excision of the eyelid, conjunctival hemorrhage, abnormal taste, conjunctival secretions increase, bazoo, depression, insomnia, anxiety, high blood pressure, heart palpitations and syncope.

Precautions

Patients with highly allergic to tartaric acid bromine brimonidine or clonidine class and are taking monoamine oxidase inhibitors in patients with the drug contraindicated. Patients with severe cardiovascular disease and impaired liver and kidney function should be used with caution. Depression, lack of cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension, thrombosis obliterans should use it very carefully. Brimonidine tartrate can cause fatigue in some patients and (or) fatigue, patients should be reminded that the FDA engaged in dangerous operations the possibility of mental concentration decline appears. Three times a day, 1 drop of two eyes. Sleep and reactive power decreased in children aged 7 to 2 years. Not recommended for children under 2 years of age.

Chemical Properties

Off-White Crystalline Solid

Uses

It is an a 2 receptor agonist. It is a drug used to treat glaucoma. It acts via decreasing aqueous humor synthesis

Uses

It is an α2 receptor agonist. It is a drug used to treat glaucoma.

Uses

Antitussive

Uses

Used to treat open-angle glaucoma or ocular hypertension

Brimonidine Tartrate Preparation Products And Raw materials

Raw materials

Preparation Products


Brimonidine Tartrate Suppliers

Global( 289)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5450 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Shochem(Shanghai) Co.,Ltd
86-21-50800795
info@shochem.com CHINA 289 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58

View Lastest Price from Brimonidine Tartrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-22 Brimonidine Tartrate
70359-46-5
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-09-29 Brimonidine Tartrate
70359-46-5
US $0.00 / g 10g 99% 10kg/month WUHAN FORTUNA CHEMICAL CO., LTD
2021-08-28 Brimonidine Tartrate
70359-46-5
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

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