3,5-DIHYDROXY-4'-BROMOSTILBENE
- CAS No.
- 1224713-90-9
- Chemical Name:
- 3,5-DIHYDROXY-4'-BROMOSTILBENE
- Synonyms
- 4-Bromo-Resveratrol;4'-bromo-Resveratrol;Resveratrol 4-Bromo Impurity;3,5-DIHYDROXY-4'-BROMOSTILBENE;4-Bromo-Resveratrol >=98% (HPLC);(E)-5-(4-Bromostyryl)benzene-1,3-diol;5-[(E)-2-(4-bromophenyl)vinyl]resorcinol;Resveratrol Impurity 22 (4'-Bromo-resveratrol);5-[(E)-2-(4-Bromophenyl)vinyl]benzene-1,3-diol;5-[(E)-2-(4-bromophenyl)ethenyl]benzene-1,3-diol
- CBNumber:
- CB8449214
- Molecular Formula:
- C14H11BrO2
- Molecular Weight:
- 291.14
- MDL Number:
- MFCD00238583
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
3,5-DIHYDROXY-4'-BROMOSTILBENE price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1078 | 4-Bromo-Resveratrol ≥98% (HPLC) | 1224713-90-9 | 5mg | $106 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1078 | 4-Bromo-Resveratrol ≥98% (HPLC) | 1224713-90-9 | 25mg | $417 | 2024-03-01 | Buy |
| Cayman Chemical | 20541 | 4'-bromo-Resveratrol ≥98% | 1224713-90-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20541 | 4'-bromo-Resveratrol ≥98% | 1224713-90-9 | 5mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 20541 | 4'-bromo-Resveratrol ≥98% | 1224713-90-9 | 10mg | $153 | 2024-03-01 | Buy |
3,5-DIHYDROXY-4'-BROMOSTILBENE Chemical Properties,Uses,Production
Biological Activity
4'-bromo-resveratrol is a sirt1 and sirt3 inhibitor.sirtuins are protein deacetylases regulating aging processes and many physiological functions. resveratrol activates human sirt1 and inhibits sirt3, and can mimic calorie restriction effects including lifespan extension in lower organisms.
in vitro
sirtuin modulation was studied by using 4’-bromo-resveratrol in a previous study. 4’-bromo-resveratrol inhibited sirt3 with much higher potency than resveratrol, and it also inhibited rather than activated sirt1. crystal structures of human sirt3/peptide complexes of 4’ -bromo-resveratrol identified two binding sites. an internal site caused the potent inhibitory effect. 4’-bromo-resveratrol interfered with nad+ and substrate peptide binding, and it extended its bromo-phenyl group in a unrecognized site pocket. the second binding site for 4’-bromo-resveratrol was found to be located on the surface of sirt3 and connected via two helices to peptide-binding active site loops. in sirt1, this site appeared to comprise a residue that was essential for its activation by small molecules and 4’-bromo-resveratrol therefore constituted a candidate for the long-sought allosteric sirt1 activator binding site [1].
References
[1] nguyen gt, gertz m, steegborn c. crystal structures of sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism. chem biol. 2013 nov 21;20(11):1375-85.
3,5-DIHYDROXY-4'-BROMOSTILBENE Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-DIHYDROXY-4'-BROMOSTILBENE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4664 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 | |
| Chengdu Chuangkecheng Biological Technology Co., Ltd. | 028-028-0000000 13008177686 | sales@ckcbiotech.com | China | 738 | 55 |
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