NVP-AAM077
- CAS No.
- 459836-30-7
- Chemical Name:
- NVP-AAM077
- Synonyms
- PEAQX;CS-1513;AAM 007;NVP-AAM077;PEAQX sodium;NVP-AAM077Na;PEAQX(NVP-AAM 077);NVP-AAM077 sodium salt;PEAQX,Inhibitor,Ionotropic glutamate receptors,inhibit,iGluR;NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem
- CBNumber:
- CB8497088
- Molecular Formula:
- C17H17BrN3O5P
- Molecular Weight:
- 454.21
- MDL Number:
- MOL File:
- 459836-30-7.mol
- MSDS File:
- SDS
| Density | 1.639±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | White solid |
| pka | 1.19±0.10(Predicted) |
| color | white to beige |
| Water Solubility | Soluble in water (10mM) |
| InChIKey | AJYMYLQKBICSOD-ULMLUZALSA-J |
| FDA UNII | LE8K7M4APN |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
NVP-AAM077 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P1999 | PEAQX tetrasodium hydrate ≥98% (HPLC) | 459836-30-7 | 5mg | $212 | 2024-03-01 | Buy |
| Sigma-Aldrich | P1999 | PEAQX tetrasodium hydrate ≥98% (HPLC) | 459836-30-7 | 25mg | $741 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5.04528 | NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem | 459836-30-7 | 5MG | $196 | 2024-03-01 | Buy |
| ApexBio Technology | B4803 | PEAQX | 459836-30-7 | 5mg | $189 | 2021-12-16 | Buy |
| ChemScene | CS-3383 | PEAQX tetrasodium hydrate ≥98.0% | 459836-30-7 | 10mg | $240 | 2021-12-16 | Buy |
NVP-AAM077 Chemical Properties,Uses,Production
Uses
PEAQX tetrasodium hydrate has been used N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) antagonist in rats and mice.
Biochem/physiol Actions
PEAQX is more specific for N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) than N-methyl-D-aspartate (NMDA) receptor 2B (NR2B) and induces striatal apoptosis. It is less potent in activating caspase-3 than its stereomer NVP-AAM007.
Enzyme inhibitor
This potent NMDA receptor antagonist and experimental anticonvulsant (FW = 542.14 g/mol), also known as NVP-AAM077 and tetrasodium [[[(1S)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5- quinoxalinyl)methyl] phosphonate, is a competitive antagonist for ionotropic glutamate [N-methyl-D-aspartate] receptors (or GluN receptors). Although originally described as being 100x more active against GluN1/GluN2A receptors versus GluN1/GluN2B receptors, later studies revealed only a 5x difference in affinity. There is no difference in the steady-state levels of inhibition produced by NVP-AAM077 when it was either preapplied or coapplied with glutamate.
storage
-20°C
NVP-AAM077 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |