NVP-CGM097
- CAS No.
- 1313363-54-0
- Chemical Name:
- NVP-CGM097
- Synonyms
- CGM097;CS-2423;CS-1248;NVP-CGM097;NVP-CGM097 (CGM097);NVP-CGM097 (FREE BASE);NVP-CGM097 HYDROCHLORIDE (HCL SALT);CGM097; CGM-097; CGM 097; NVPCGM097; NVPCGM 097; NVPCGM-097;(S)-1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-[methyl[4-(4-methyl-3-oxopiperazin-1-yl)-trans-cyclohexylmethyl]amino]phenyl)-1,4-dihydro-2H-isoquinolin-3-one;(S)-1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-(methyl(((1r,4S)-4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl)methyl)amino)phenyl)-1,2-dihydroisoquinolin-3(4H)-one
- CBNumber:
- CB22715661
- Molecular Formula:
- C38H47ClN4O4
- Molecular Weight:
- 659.26
- MDL Number:
- MFCD28144684
- MOL File:
- 1313363-54-0.mol
Boiling point | 830.1±65.0 °C(Predicted) |
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Density | 1.210±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO:50.0(Max Conc. mg/mL);75.84(Max Conc. mM) |
pka | 8.31±0.20(Predicted) |
form | Powder |
color | Light yellow to yellow |
FDA UNII | 4UF6MSL0ZH |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
NFPA 704 |
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NVP-CGM097 price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 29519 | NVP-CGM097 | 1313363-54-0 | 1mg | $93 | 2024-03-01 | Buy |
Cayman Chemical | 29519 | NVP-CGM097 | 1313363-54-0 | 10mg | $593 | 2024-03-01 | Buy |
Cayman Chemical | 29519 | NVP-CGM097 | 1313363-54-0 | 5mg | $321 | 2024-03-01 | Buy |
ChemScene | CS-3138 | NVP-CGM097 98.32% | 1313363-54-0 | 5mg | $264 | 2021-12-16 | Buy |
ChemScene | CS-3138 | NVP-CGM097 98.32% | 1313363-54-0 | 10mg | $444 | 2021-12-16 | Buy |
NVP-CGM097 Chemical Properties,Uses,Production
Biological Activity
NVP-CGM097 is a potent and selective MDM2 inhibitor with a Ki value of 1.3 nM. It binds to the p53-binding site of the MDM2 protein, disrupting its protein-protein interactions, leading to activation of the p53 pathway.
in vitro
The binding ability of NVP-CGM097 to MDM2 varies among different species. The selectivity of it for p53:MDM2 interaction is 1176-fold for p53:MDM4 interaction, 3000-fold for Ras:Raf interaction, and 1176-fold for Bcl-2:Bak, Bcl-2:Bad, Mcl- The interaction of 1:Bak, Mcl-1:NOXA, XIAP:BIR3, c-IAP:BIR3 is inactive, therefore, it is highly selective for p53:MDM2. It can significantly promote the entry of wild-type p53 into the nucleus with IC50 of 0.224 μM, indicating that it can inhibit the p53:MDM2 interaction in living cells. It promotes p53 as nucleus, resulting in cellular p53-dependent growth inhibition.
in vivo
After intravenous injection, the serum clearance of NVP-CGM097 was 5 mL/min/kg in mice, 7 mL/min/kg in rats, 3 mL/min/kg in dogs, and 3 mL/min/kg in monkeys. 4 mL/min/kg. Serum clearance of NVP-CGM097 was low in all species compared to hepatic blood flow (typically 5-10% hepatic blood flow). The half-life of NVP-CGM097 in rodents and monkeys is 6-12 hours; in dogs, the half-life is 20 hours, which is relatively longer.
target
Target | Value |
hMDM2 (Cell-free assay) | 1.7 nM |
NVP-CGM097 Preparation Products And Raw materials
Raw materials
Preparation Products
NVP-CGM097 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20356 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20291 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40068 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Chembest Research Laboratories Limited | +86-21-20908456 | sales@BioChemBest.com | China | 6008 | 61 |