ChemicalBook >> CAS DataBase List >>L-838417
L-838417
- CAS No.
- 286456-42-6
- Chemical Name:
- L-838417
- Synonyms
- L-838417 ;L-838417_x000b_;5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1,2,4-triazole;7-(tert-Butyl)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine;3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine;1,2,4-Triazolo[4,3-b]pyridazine,3-(2,5-difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-;3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-β]pyridazine
- CBNumber:
- CB8506755
- Molecular Formula:
- C19H19F2N7O
- Molecular Weight:
- 399.4
- MDL Number:
- MFCD08690609
- MOL File:
- 286456-42-6.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| Melting point | 196-198°C |
|---|---|
| Density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | DMSO: ≥20mg/mL |
| pka | 2.13±0.10(Predicted) |
| form | powder |
| color | white to off-white |
| FDA UNII | 8CZO0970G3 |
L-838417 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 3250 | L-838,417 ≥98%(HPLC) | 286456-42-6 | 10 | $216 | 2021-12-16 | Buy |
| Tocris | 3250 | L-838,417 ≥98%(HPLC) | 286456-42-6 | 50 | $893 | 2021-12-16 | Buy |
| TRC | L838417 | L-838417 | 286456-42-6 | 50mg | $740 | 2021-12-16 | Buy |
| TRC | L838417 | L-838417 | 286456-42-6 | 5mg | $145 | 2021-12-16 | Buy |
| Usbiological | 281181 | L-838417 | 286456-42-6 | 2mg | $418 | 2021-12-16 | Buy |
L-838417 Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
L-838417 is an anxiolytic agent and a selective GABAA receptor partial agonist that selectively binds to α1, α2, α3 and α5 subunits (1,2). It also exhibits antinociceptive and anti-inflammatory properties.
Uses
A selective ligand for GABAA receptors
Biological Activity
Subtype-selective GABA A receptor partial agonist. Selectively binds to α 1, α 2, α 3 and α 5 subunits (K i values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α 1 ( α 1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo .
storage
Store at +4°C
L-838417 Preparation Products And Raw materials
Raw materials
Preparation Products
L-838417 Suppliers
Global( 47)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
286456-42-6(L-838417 )Related Search:
3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-β]pyridazine
7-(tert-Butyl)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine
1,2,4-Triazolo[4,3-b]pyridazine,3-(2,5-difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-
L-838417
3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1,2,4-triazole
L-838417_x000b_
286456-42-6
C19H19F2N7O
Heterocycles
Intermediates & Fine Chemicals
Heterocyclic Compounds
Pharmaceuticals