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AC-SER-ASP-LYS-PRO-OH

AC-SER-ASP-LYS-PRO-OH structure

CAS No.: 127103-11-1

Chemical Name:: AC-SER-ASP-LYS-PRO-OH

Synonyms: AC-SDKP;GORALATIDE;Acetyl-SDKP;SERASPENIDE;AC-SDKP-DELTA;Thymosin β4 (1-4);Thymosin β4 (1-4);AC-SER-ASP-LYS-PRO;Thymosin beta4 (1-4);AC-SER-ASP-LYS-PRO-O

CBNumber:: CB8704926

Molecular Formula:: C20H33N5O9

Molecular Weight:: 487.5

MDL Number:: MFCD00076849

MOL File:: 127103-11-1.mol

MSDS File:: SDS

Last updated:2024-05-18 08:51:57

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AC-SER-ASP-LYS-PRO-OH Properties

storage temp.	−20°C
solubility	Soluble in DMSO
form	Solid
color	White to off-white
Water Solubility	Soluble in water at 2mg/ml
Sequence	H-Gln-Lys-Leu-Val-Phe-Phe-Ala-OH
FDA UNII	H041538E9P

SAFETY

Risk and Safety Statements

WGK Germany	3

AC-SER-ASP-LYS-PRO-OH price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Alfa Aesar	J66430	N-Acetyl-Ser-Asp-Lys-Pro	127103-11-1	5mg	$64.6	2023-06-20	Buy
Biosynth Carbosynth	FA108367	Ac-Ser-Asp-Lys-Pro-OH	127103-11-1	5mg	$131	2021-12-16	Buy
Biosynth Carbosynth	FA108367	Ac-Ser-Asp-Lys-Pro-OH	127103-11-1	10mg	$228	2021-12-16	Buy
Biosynth Carbosynth	FA108367	Ac-Ser-Asp-Lys-Pro-OH	127103-11-1	25mg	$456	2021-12-16	Buy
American Custom Chemicals Corporation	PEP0002574	N-ACETYL-SER-ASP-LYS-PRO 95.00%	127103-11-1	5MG	$718.47	2021-12-16	Buy

Product number	Packaging	Price	Buy
J66430	5mg	$64.6	Buy
FA108367	5mg	$131	Buy
FA108367	10mg	$228	Buy
FA108367	25mg	$456	Buy
PEP0002574	5MG	$718.47	Buy

AC-SER-ASP-LYS-PRO-OH Chemical Properties,Uses,Production

Skin Benifits

AcSDKP is an oligopeptide composed of acetyl-Ser-Asp-Lys-Pro. Found at low concentrations endogenously, AcSDKP is produced from thymosin and inhibits the phosphorylation of Smad2, therefore downsizing the expression of genes regulated by TGFβ. This mechanism mediates an antifibrotic effect and a reduction in edema. AcSDKP is catabolized almost exclusively by angiotensin converting enzyme I (ACEI), although ACEI-resistant analogs have been created. AcSDKP has been recognized as a potent inducer of angiogenesis and an anti-inflammatory agent, also contributing to its anti-fibrotic effects. Its cutaneous anti-aging effects have also been investigated. AcSDKP at a concentration of 10−7–10−11 stimulates the expression of proteins that strengthen tight junctions, including caludin-1, occluding, and ZO-1.
In an ex vivo study, topical AcSDKP accelerated skin healing after UV irradiation. AcSDKP also stimulates the proliferation of keratinocytes, fibroblasts, and epidermal basal layer cells. Topical application of 10−5 M AcSDKP also inhibits aging of human skin explants by significantly increasing epidermal thickness after only six days, increases collagen III along the papillary dermis and collagen IV along the basal membrane, with a concomitant increase in GAGs, especially HA. This peptide also modulates the growth of human hair in an ex vivo study. Treatment of normal human dermal fibroblast cells with AcSDKP showed increased collagen I synthesis and SIRTI, improving skin structure and increasing cell longevity.78 In one study, topically administered AcSDKP on an ex vivo skin-explant model significantly increases epidermis thickness after only six days of treatment with 10−8 M AcSKDP. In addition to upregulating the expression of collagen and fibronectin along the dermo-epithelial junction, AcSKDP also increases GAG deposited in the ECM, especially hyaluronic acid. Lastly, AcSDKP encourages dermal fibroblasts and keratinocytes to proliferate and modulates hair growth.

Uses

N-Acetyl-Ser-Asp-Lys-Pro inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. It is a specific substrate for the N-terminal active site of angiotensin converting enzyme, which is responsible for its degradation in vivo.

AC-SER-ASP-LYS-PRO-OH Preparation Products And Raw materials

Raw materials

Preparation Products

AC-SER-ASP-LYS-PRO-OH Suppliers

Global( 135)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zhejiang Hangyu API Co., Ltd	+8617531972939	anna@api-made.com	China	2944	58
Shanghai Yunao International Trade Co., Ltd	+8617621705551	asdf@shanghaihg.cn	China	265	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
zhuzhou dingcheng meihei comestic co.,ltd	+8618873369619	dingchengbusiness8@163.com	China	260	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	971	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	1142	58
Shanghai Getian Industrial Co., LTD	+86-15373193816 +86-15373193816	mike@ge-tian.com	China	274	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	16224	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10247	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58

Supplier	Advantage
Zhejiang Hangyu API Co., Ltd	58
Shanghai Yunao International Trade Co., Ltd	58
Nantong Guangyuan Chemicl Co,Ltd	58
zhuzhou dingcheng meihei comestic co.,ltd	58
hebei hongtan Biotechnology Co., Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Shanghai Getian Industrial Co., LTD	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from AC-SER-ASP-LYS-PRO-OH manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-06-13	Goralatide 127103-11-1	US $30.00 / box	1box	98%	2000kg	hebei hongtan Biotechnology Co., Ltd
2024-06-11	Thymosin β4 (1-4) 127103-11-1	US $30.00 / Box	1Box	99.99%	10000000000	zhuzhou dingcheng meihei comestic co.,ltd
2024-05-18	AC-SER-ASP-LYS-PRO-OH 127103-11-1	US $25.00-20.00 / box	1box	99%	100000box	Shanghai Getian Industrial Co., LTD

Goralatide
127103-11-1
US $30.00 / box
98%
hebei hongtan Biotechnology Co., Ltd

Thymosin β4 (1-4)
127103-11-1
US $30.00 / Box
99.99%
zhuzhou dingcheng meihei comestic co.,ltd

AC-SER-ASP-LYS-PRO-OH
127103-11-1
US $25.00-20.00 / box
99%
Shanghai Getian Industrial Co., LTD

127103-11-1(AC-SER-ASP-LYS-PRO-OH)Related Search:

ARG-PRO-PRO-GLY-PHE-SER-PRO-LEU PYR-HIS-TRP-SER-TYR-GLY-TRP-LEU-PRO-GLY-NH2 H-ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN-OH ALA-D-GAMMA-GLU-LYS-D-ALA-D-ALA LHRH

Goserelin Gonadorelin Gonadorelin impurity Fluralaner

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SERASPENIDE ACETYL-SER-ASP-LYS-PRO AC-SDKP AC-SDKP-DELTA AC-SER-ASP-LYS-PRO AcSDKP Ac-Ser-Asp-Lys-Pro REF DUPL: Ac-Ser-Asp-Lys-Pro-OH AcSDKP, SteM Cell Proliferation Inhibitor, Goralatide, ThyMosin b4 (1-4) Acetyl-SDKP AC-SER-ASP-LYS-PRO-OH Thymosin β4 (1-4) Ac-L-Ser-L-Asp-L-Lys-L-Pro-OH N-Acetyl-Ser-Asp-Lys-Pro-OH N-Ac-Ser-Asp-Lys-Pro-OH Acetyl-serinyl-aspartyl-lysinyl-proline GORALATIDE L-Proline, N-acetyl-L-seryl-D-α-aspartyl-L-lysyl- AC-SER-ASP-LYS-PRO-OH USP/EP/BP 1-[2-[[2-[(2-acetamido-3-hydroxypropanoyl)amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylic acid Thymosin β4 (1-4) Ac-Ser-Asp-Lys-Pro-OH (H-1156.0005) Ac-SDKP,NAcetylSerAspLysPro,Inhibitor,inhibit,N Acetyl Ser Asp Lys Pro,Angiotensin-converting Enzyme (ACE) Thymosin beta4 (1-4) AC-SER-ASP-LYS-PRO-O 127103-11-1 C20H33N5O9 Peptides BioChemical Angiotensins Amino Acids and Peptides Biochemicals and Reagents Peptide Angiotensins Peptides for Cell Biology