Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
- CAS No.
- 656235-44-8
- Chemical Name:
- Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
- Synonyms
- Boronic acid, (2-cyano-6-fluorophenyl)-;2-Cyano-6-fluorophenylboronic acid 95+%;Boronic acid, B-(2-cyano-6-fluorophenyl)-;Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
- CBNumber:
- CB91065223
- Molecular Formula:
- C7H5BFNO2
- Molecular Weight:
- 164.93
- MDL Number:
- MFCD09033623
- MOL File:
- 656235-44-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Cyano-6-fluorophenylboronicacid | C987553 | 50mg | $55 |
| (2-cyano-6-fluorophenyl)boronic Acid | FC104753 | 500mg | $150 |
| (2-cyano-6-fluorophenyl)boronic Acid | FC104753 | 1g | $230 |
| (2-cyano-6-fluorophenyl)boronic Acid | FC104753 | 2g | $350 |
| 2-CYANO-6-FLUOROPHENYLBORONIC ACID 95.00% | BOR0003780 | 1G | $370.65 |
| More product size | |||
| Boiling point | 367.7±52.0 °C(Predicted) |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 7.77±0.58(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C7H5BFNO2/c9-6-3-1-2-5(4-10)7(6)8(11)12/h1-3,11-12H |
| InChIKey | PPLSIVNRHUSMMC-UHFFFAOYSA-N |
| SMILES | B(C1=C(F)C=CC=C1C#N)(O)O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2931900090 |
Boronic acid, (2-cyano-6-fluorophenyl)- (9CI) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C987553 | 2-Cyano-6-fluorophenylboronicacid | 656235-44-8 | 50mg | $55 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC104753 | (2-cyano-6-fluorophenyl)boronic Acid | 656235-44-8 | 500mg | $150 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC104753 | (2-cyano-6-fluorophenyl)boronic Acid | 656235-44-8 | 1g | $230 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC104753 | (2-cyano-6-fluorophenyl)boronic Acid | 656235-44-8 | 2g | $350 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BOR0003780 | 2-CYANO-6-FLUOROPHENYLBORONIC ACID 95.00% | 656235-44-8 | 1G | $370.65 | 2021-12-16 | Buy |
Boronic acid, (2-cyano-6-fluorophenyl)- (9CI) Chemical Properties,Uses,Production
Uses
2-Cyano-6-fluorophenylboronic acid
Synthesis
403-54-3
656235-44-8
General procedure for the synthesis of 2-cyano-6-fluorophenylboronic acid from 3-fluorobenzonitrile: To a 500 mL three-necked round-bottomed flask equipped with a magnetic stirring bar, a dosing funnel, and a nitrogen inlet, under nitrogen protection, were added 3-fluorobenzonitrile (10.0 g, 82.56 mmol), triisopropyl borate (28.5 mL, 23.3 g, 123.84 mmol), and 100 mL anhydrous THF.The reaction mixture was cooled to -50 °C and a THF/hexane solution of LDA (86.7 mmol, freshly prepared from 8.77 g of diisopropylamine in 20 mL of THF and 54.2 mL of 1.6 M n-BuLi in hexane) was added dropwise over a period of 1 hour. The reaction mixture was slowly warmed to -5 °C and stirred at this temperature for 30 min. Subsequently, 70 mL of 5N HCl aqueous solution and 50 mL of MTBE were added and stirred for 30 min at room temperature. The reaction mixture was extracted with MTBE (4 x 100 mL), the organic phases were combined, washed with brine (2 x 100 mL), concentrated under reduced pressure, controlled to a temperature lower than 20 °C, and finally dried in vacuo at room temperature to give 12.16 g (89% yield) of 2-cyano-6-fluorophenylboronic acid as a white solid.LCMS m/z (M+H)+: 165.8. 1H NMR ( 300 MHz, DMSO-d6): δ 8.92 (2H), 7.65 (1H), 7.57 (1H), 7.49 (1H).
References
[1] Patent: WO2006/51410, 2006, A1. Location in patent: Page/Page column 44
[2] Journal of Organic Chemistry, 2005, vol. 70, # 15, p. 5938 - 5945
[3] Journal of Organic Chemistry, 2004, vol. 69, # 2, p. 566 - 569
Boronic acid, (2-cyano-6-fluorophenyl)- (9CI) Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Nanjing jinheyou Trading Co., Ltd. | 15705188088 | admin@jheyou.com | CHINA | 1268 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49968 | 58 |
| Tianjin Xinghan Biotechnology Co., Ltd | +8618698089028 | 1725517238@qq.com | China | 2479 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Shanghai Scochem Technology Co., Ltd | +86-021-33758897 +86-13701882790 | sales@scochem.com | China | 1977 | 58 |
View Lastest Price from Boronic acid, (2-cyano-6-fluorophenyl)- (9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-13 | Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
656235-44-8
|
US $1.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co | |
 |
2019-12-31 | Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
656235-44-8
|
US $0.00 / g | 1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. | |
 |
2019-12-31 | Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
656235-44-8
|
US $0.00 / g | 1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. |
-
- Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
656235-44-8
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
-
- Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
656235-44-8
- US $0.00 / g
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
-
- Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
656235-44-8
- US $0.00 / g
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
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