ChemicalBook
Chinese Japanese Germany Korea

Lithium diisopropylamide

Lithium diisopropylamide
Lithium diisopropylamide structure
CAS No.
4111-54-0
Chemical Name:
Lithium diisopropylamide
Synonyms
LDA;DIIS;Lithium salt;iisopropylamide;LDA THF COMPLEX;Lithium diisopropyla;Diisopropyllithioamine;DIISOPROPYLAMINOLITHIUM;LithiuM diisopropylaMid;LITHIUM DIISOPROPYLAMINE
CBNumber:
CB6677718
Molecular Formula:
C6H14LiN
Formula Weight:
107.12306
MOL File:
4111-54-0.mol

Lithium diisopropylamide Properties

Melting point:
decomposes [MER06]
Boiling point:
65 °C
Density 
0.864 g/mL at 25 °C(lit.)
vapor density 
>1 (vs air)
Flash point:
91 °F
storage temp. 
2-8°C
form 
liquid
color 
brown
Water Solubility 
decomposes
Sensitive 
Air & Moisture Sensitive
Merck 
14,3196
BRN 
3655042
CAS DataBase Reference
4111-54-0(CAS DataBase Reference)
EPA Substance Registry System
2-Propanamine, N-(1-methylethyl)-, lithium salt(4111-54-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  C,N,F
Risk Statements  14-17-34-67-65-51/53-35-19-15-11-50/53-14/15-10-40-23/24/25-62-63-37-48/20
Safety Statements  26-36/37/39-43-45-60-61-62-8-16-23-33-27
RIDADR  UN 3399 4.3/PG 2
WGK Germany  3
1-10
TSCA  Yes
HazardClass  4.2
PackingGroup  I
HS Code  29211990
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H250 Catches fire spontaneously if exposed to air Pyrophoric liquids; Pyrorophoric solids Category 1 Danger P210, P222, P280, P302+P334,P370+P378, P422
H261 In contact with water releases flammable gas Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases Category 2
Category 3
Danger
Warning
P231+P232, P280, P370+P378,P402+P404, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H304 May be fatal if swallowed and enters airways Aspiration hazard Category 1 Danger
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H333 May be harmful if inhaled Acute toxicity,inhalation Category 5 P304+P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P222 Do not allow contact with air.
P223 Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P231 Handle under inert gas.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P422 Store contents under …
P403+P235 Store in a well-ventilated place. Keep cool.

Lithium diisopropylamide price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 246611 Lithium diisopropylamide 97% 4111-54-0 25g $198 2018-11-20 Buy
Sigma-Aldrich 246611 Lithium diisopropylamide 97% 4111-54-0 100g $627 2018-11-20 Buy
TCI Chemical L0171 Lithium Diisopropylamide (ca. 20% in Tetrahydrofuran/Ethylbenzene/Heptane, ca. 1.5mol/L) 4111-54-0 100mL $60 2018-11-22 Buy
TCI Chemical L0171 Lithium Diisopropylamide (ca. 20% in Tetrahydrofuran/Ethylbenzene/Heptane, ca. 1.5mol/L) 4111-54-0 500mL $167 2018-11-22 Buy
Sigma-Aldrich 361798 Lithium diisopropylamide solution 2.0 M in THF/heptane/ethylbenzene 4111-54-0 4x100ml $182 2018-11-13 Buy

Lithium diisopropylamide Chemical Properties,Uses,Production

Chemical Properties

dark yellow to orange or dark red-brown solution

Chemical Properties

Lithium diisopropylamide (LDA) is a white pyrophoric powder. Freshly prepared, it is soluble in hydrocarbons (in hexane about 10 %), but it tends to precipitate irreversibly from solution as a polymer on heating or prolonged storage. In ethers the solubility is much higher, but with the exception of tetrahydropyran, LDA is decomposed at a rate depending on the ether, concentration, and temperature.
Lithium diisopropylamide can be conveniently prepared from butyllithium and diisopropylamine or purchased as a 2 mol/L (25 %) solution in THF and a mixture of various hydrocarbons. Although LDA is unstable in pure THF (at room temperature a 25% solution loses about 1% of its activity per day), the commercially available compositions containing only a limited amount of THF are satisfactory stable for technical applications.

Uses

Lithium diisopropylamide is a sterically hindered nonnucleophilic strong base used for selective deprotonations, especially for the production of kinetic enolates (i.e., the thermodynamically less favored isomer) and (hetero-)aromatic carbanions. In the production of the serum lipid regulating agent Gemfibrozil one key intermediate is formed by quenching an ester enolate with 1-bromo-3-chloropropane.

Uses

pH adjuster in colognes and toilet waters. In organic synthesis, particularly, the lithium salt.

Purification Methods

It is purified by refluxing over Na wire or NaH for 30minutes and then distilled into a receiver under N2. Because of the low boiling point of the amine, a dispersion of NaH in mineral oil can be used directly in this purification without prior removal of the oil. It is HIGHLY FLAMMABLE, and is decomposed by air and moisture. [Wittig & Hesse Org Synth 50 69 1970, Beilstein 4 H 154, 4 I 369, 4 II 630, 4 III 274, 4 IV 510.]

Lithium diisopropylamide Preparation Products And Raw materials

Raw materials

Preparation Products


Lithium diisopropylamide Suppliers

Global( 193)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21914 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1530 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20602 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23982 58
Chengdu Hongsheng Sci-Tech Development Co..,Ltd 86-028-37690186,18089504818,13568974161
86-028-37690186 cdchemical@163.com China 40 58
Sichuan Weibo Science and Technology Co., Ltd. +86 (28) 8757-8473 / +86 13880582998
+86 (28) 8757-8473 ellnn@163.com China 50 60
Beijing Xinsavi Chemical Technology Co., Ltd. 13717722232
010-56218800 xinsavichem@163.com China 4822 56

View Lastest Price from Lithium diisopropylamide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-25 Lithium diisopropylamide
4111-54-0
US $1.00 / kg 1kg 99% Customized career henan chemical co

4111-54-0(Lithium diisopropylamide)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved