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1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) structure

CAS No.: 116855-08-4

Chemical Name:: 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)

Synonyms: 1H-Pyrazolo[3,4-b]pyridin-3-carboxylic acid;2h-pyrazolo[3,4-b]pyridine-3-carboxylic Acid;1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI);1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid ,97%;1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid (9CI, ACI)

CBNumber:: CB91285429

Molecular Formula:: C7H5N3O2

Molecular Weight:: 163.13

MDL Number:: MFCD11040725

MOL File:: 116855-08-4.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:40

Product description	Number	Pack Size	Price
1H-Pyrazolo[3,4-b]pyridine-3-carboxylicAcid	P840440	50mg	$45
1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid	OR305633	250mg	$65
1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid	X9182	250mg	$103
1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid	040865	1g	$108
1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid	OR305633	1g	$144
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1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) Properties

Melting point	265-270℃ (DEC.)
Boiling point	391.1±25.0 °C(Predicted)
Density	1.68
storage temp.	2-8°C
pka	8.83±0.20(Predicted)
Appearance	Light yellow to brown Solid
InChI	InChI=1S/C7H5N3O2/c11-7(12)5-4-2-1-3-8-6(4)10-9-5/h1-3H,(H,11,12)(H,8,9,10)
InChIKey	UFKAACYLUOQSFH-UHFFFAOYSA-N
SMILES	C12NN=C(C(O)=O)C1=CC=CN=2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Risk Statements	20/21/22
Safety Statements	24/25-36/37
HS Code	29339900

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	P840440	1H-Pyrazolo[3,4-b]pyridine-3-carboxylicAcid	116855-08-4	50mg	$45	2021-12-16	Buy
Apolloscientific	OR305633	1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid	116855-08-4	250mg	$65	2021-12-16	Buy
AK Scientific	X9182	1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid	116855-08-4	250mg	$103	2021-12-16	Buy
Matrix Scientific	040865	1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid	116855-08-4	1g	$108	2021-12-16	Buy
Apolloscientific	OR305633	1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid	116855-08-4	1g	$144	2021-12-16	Buy

Product number	Packaging	Price	Buy
P840440	50mg	$45	Buy
OR305633	250mg	$65	Buy
X9182	250mg	$103	Buy
040865	1g	$108	Buy
OR305633	1g	$144	Buy

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) Chemical Properties,Uses,Production

Chemical Properties

Light yellow solid

Uses

1h-Pyrazolo[3,4-B]Pyridine-3-Carboxylic Acid is a useful research chemical.

Synthesis

1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI)

116834-96-9

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)

116855-08-4

Step 4: To an aqueous solution (20 mL) containing NaOH (0.88 g, 22 mmol) was added 3-methyl-1H-pyrazolo[3,4-b]pyridine (IV) (0.4 g, 3 mmol). The suspension was heated at 80°C until a clarified solution was formed. Subsequently, an aqueous solution (180 mL) of KMnO4 (1.73 g, 11 mmol) was added slowly over a period of 2 hours while keeping the solution heated at 80°C. The solution was heated at 90°C for 2 hours. The reaction mixture was continued to be heated at 90°C for 2 hours until the complete disappearance of the feedstock was confirmed by thin layer chromatography (TLC). The solution was cooled to 70°C and filtered through a diatomaceous earth pad. The solids were washed with boiling water. The filtrates were combined and cooled to 0°C and acidified with concentrated HCl to pH=2. The acidified solution was extracted with n-butanol (2 x 10 mL). The n-butanol layer was concentrated under reduced pressure to give a white residue. The residue was dissolved in dichloromethane (DCM), a minimum amount of methanol (MeOH) was added to aid solubilization, and then filtered. The filtrate was concentrated to afford 1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (V) as a white solid (390 mg, 2.39 mmol, 81% yield).1H NMR (CDCl3) δ ppm: 7.37 (dd, J = 8.10, 4.52 Hz, 1H), 8.47 (dd, J = 7.54, 1.88 Hz, 1H), 8.62 (dd, J = 7.54, 1.88 Hz, 1H), 8.63 (dd, J = 7.54, 1.88 Hz, 1H). 8.62 (dd, J = 4.52, 1.32 Hz, 1H), 14.37 (brs, 1H).

References

[1] Patent: WO2011/84486, 2011, A1. Location in patent: Page/Page column 106; 111-112
[2] Patent: US2013/296302, 2013, A1. Location in patent: Paragraph 0496
[3] Patent: US2016/68550, 2016, A1. Location in patent: Paragraph 1058
[4] Patent: WO2016/40193, 2016, A1. Location in patent: Paragraph 0705
[5] Canadian Journal of Chemistry, 1988, vol. 66, # 3, p. 420-428

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution Ethanol Zinc chloride Polyphosphoric acid 1-Pentanol

3-Aminocrotononitrile Potassium permanganate 1,1,3,3-Tetramethoxypropane 3-Amino-5-methylpyrazole 1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI)

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Preparation Products

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) Suppliers

Global( 131)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Changzhou PBpharmaceutical R&D Co.,Ltd	0519-83990708	info@pbpharm.com	CHINA	498	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29798	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14359	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	CHINA	4017	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Nexconn Pharmatechs Ltd	58
Changzhou PBpharmaceutical R&D Co.,Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Win-Win chemical CO., Limited	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Nextpeptide Inc	58

View Lastest Price from 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-04-04	1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) 116855-08-4	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
	2019-12-20	1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) 116855-08-4	US $1.00 / KG	1KG	97-99%	1000KGS	Career Henan Chemical Co

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)
116855-08-4
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)
116855-08-4
US $1.00 / KG
97-99%
Career Henan Chemical Co

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) Spectrum

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)(116855-08-4)¹HNMR

116855-08-4(1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI))Related Search:

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5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID TERT-BUTYL 6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLATE 1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID 1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBALDEHYDE

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1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid ,97% 1H-Pyrazolo[3,4-b]pyridin-3-carboxylic acid 2h-pyrazolo[3,4-b]pyridine-3-carboxylic Acid 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid (9CI, ACI) 116855-08-4 GLYCINESCAFFOLD Heterocycle-Pyridine series