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lycorenine

CAS No.
477-19-0
Chemical Name:
lycorenine
Synonyms
ycorenine;lycorenine;lycorenine USP/EP/BP;9,10-Dimethoxy-1-methyllycorenan-7α-ol;(7alpha)-9,10-dimethoxy-1-methyllycorenan-7-ol;(5aR,7S,11bS,11cS)-9,10-dimethoxy-1-methyl-3,5,5a,7,11b,11c-hexahydro-2H-isochromeno[3,4-g]indol-7-ol;(5aR,7S,11bS,11cS)-1,2,3,5,5a,7,11b,11c-Octahydro-9,10-dimethoxy-1-methyl-[2]benzopyrano[3,4-g]indol-7-ol;[2]Benzopyrano[3,4-g]indol-7-ol, 1,2,3,5,5a,7,11b,11c-octahydro-9,10-dimethoxy-1-methyl-,(5aR,7S,11bS,11cS)-
CBNumber:
CB91377212
Molecular Formula:
C18H23NO4
Molecular Weight:
317.38
MDL Number:
MFCD09954183
MOL File:
477-19-0.mol
Last updated:2023-05-04 17:34:39

lycorenine Properties

Melting point 199-200℃
Boiling point 477.7±45.0 °C(Predicted)
Density 1.28
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form Cryst.
pka 11.98±0.20(Predicted)

lycorenine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 300598 Lycorenine 477-19-0 20mg $490 2021-12-16 Buy
Biorbyt Ltd orb105529 Lycorenine >98% 477-19-0 20mg $569.5 2021-12-16 Buy
AvaChem 1806 Lycorenin 477-19-0 10mg $690 2021-12-16 Buy
DC Chemicals DCS-119 Lycorenine >98%,StandardReferencesGrade 477-19-0 20mg $280 2021-12-16 Buy
Product number Packaging Price Buy
300598 20mg $490 Buy
orb105529 20mg $569.5 Buy
1806 10mg $690 Buy
DCS-119 20mg $280 Buy

lycorenine Chemical Properties,Uses,Production

Description

An alkaloid isolated from Lycoris radiata Herb. the base crystallizes from Me2CO in rhombic prisms and has [α]20D + 149.3°. The alkaloid yields crystalline salts and derivatives, e.g. the aurichloride decomposing at 116°C, platinichloride, also decomposing before melting at 210°C; picrate, m.p. 162°C (dec.); monoacetyl derivative, m.p. 185 _7°C. The diacetyl compound has been prepared although with some difficulty and under forcing conditions, m.p. 17 5-6°C. The alkaloid behaves as a pseudo-base giving an oxime hydrochloride which decomposes at 258°C. On catalytic hydrogenation it yields the dihydro-derivative, m.p. 175- 7°C and prolonged hydrogenation eventually forms deoxytetrahydrolycorenine, ClsH2S03N, m.p. 165-8°C although other compounds are also formed at the same time, e.g. C1sH27 0 2N, m.p. l65-7°C and ClsH2S03N, m.p. l20-3°C. The methiodide decomposes when heated at 260°C and on treatment with silver oxide forms two methine bases, of which the (±)-form has been isolated as the methiodide, m.p. 223°C (dec.). The complete structure has been determined primarily from the mass spectrum.

Uses

Lycorenine is an antibacterial agent extracted from the bulb of Lycoris radiata.

Definition

ChEBI: Lycorenine is an alkaloid.

target

Antifection

References

Kondo, Tomimura, Ishiwatari., J. Pharrn. Soc., Japan, 52, 51 (1932) Spectra: Inuka et aI., Tetrahedron Lett., 4745 (1966) Stereochemistry: Mizukami., Tetrahedron, 11,89 (1960)

lycorenine Preparation Products And Raw materials

Raw materials

Preparation Products

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lycorenine [2]Benzopyrano[3,4-g]indol-7-ol, 1,2,3,5,5a,7,11b,11c-octahydro-9,10-dimethoxy-1-methyl-,(5aR,7S,11bS,11cS)- 9,10-Dimethoxy-1-methyllycorenan-7α-ol (5aR,7S,11bS,11cS)-9,10-dimethoxy-1-methyl-3,5,5a,7,11b,11c-hexahydro-2H-isochromeno[3,4-g]indol-7-ol (5aR,7S,11bS,11cS)-1,2,3,5,5a,7,11b,11c-Octahydro-9,10-dimethoxy-1-methyl-[2]benzopyrano[3,4-g]indol-7-ol ycorenine lycorenine USP/EP/BP (7alpha)-9,10-dimethoxy-1-methyllycorenan-7-ol 477-19-0