Benzyl (3-bromopropyl)carbamate
- CAS No.
- 39945-54-5
- Chemical Name:
- Benzyl (3-bromopropyl)carbamate
- Synonyms
- Nsc78814;Wln: E3mvo1r;N-BOC-3-BROMOPROPYLAMINE;3-Bromo-N-Cbz-1-propanamine;Benzyl (3-bromopropyl)carbamate;Benzyl N-(3-broMopropyl)carbaMate;TERT-BUTYL N-(3-BROMOPROPYL)CARBAMATE;(3-bromopropyl)carbamicacidbenzylester;(3-bromopropyl)-carbamicacibenzylester;N-Benzyloxycarbonyl-3-Bromopropylamine
- CBNumber:
- CB9139372
- Molecular Formula:
- C11H14BrNO2
- Molecular Weight:
- 272.14
- MDL Number:
- MFCD01737871
- MOL File:
- 39945-54-5.mol
- MSDS File:
- SDS
| Melting point | 37-39 °C |
|---|---|
| Boiling point | 379.4±35.0 °C(Predicted) |
| Density | 1.379±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Sparingly), Methanol (Slightly) |
| form | Solid |
| pka | 12.27±0.46(Predicted) |
| color | Off-White |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| F | 10-21 |
Benzyl (3-bromopropyl)carbamate price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B233475 | Benzyl3-bromopropylcarbamate | 39945-54-5 | 100mg | $45 | 2021-12-16 | Buy |
| Usbiological | 165464 | N-tert-Butoxycarbonyl-3-bromopropylamine | 39945-54-5 | 1g | $460 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0174210 | BENZYL 3-BROMOPROPYLCARBAMATE 95.00% | 39945-54-5 | 5MG | $497.4 | 2021-12-16 | Buy |
| Crysdot | CD12075179 | Benzyl(3-bromopropyl)carbamate 95+% | 39945-54-5 | 25g | $713 | 2021-12-16 | Buy |
| Alichem | 39945545 | Benzyl(3-bromopropyl)carbamate | 39945-54-5 | 25g | $763.2 | 2021-12-16 | Buy |
Benzyl (3-bromopropyl)carbamate Chemical Properties,Uses,Production
Uses
N-tert-Butoxycarbonyl-3-bromopropylamine, is a versatile building block used in the synthesis of various pharmaceutical and biologically active compounds. It has been shown to be utilized in the synthesis of an active anti-HIV ethidium-arginine conjugate targeted against the viral TAR RNA sequence.
Synthesis
Benzyl N-(3-bromopropyl)carbamate synthesis: A solution of triphenylphosphine (9.4 g, 28.60 mmol) and carbon tetrabromide (7.5 g, 28.60 mmol) in dry THF was added dropwise (30 mL) to a solution of benzyl N-(3-hydroxypropyl)carbamate (3.0 g, 14.30 mmol) in the same solvent (30 mL). After 48 h of stirring at room temperature, the solution was filtrated to remove an insoluble solid. After evaporation of filtrate, the residue was dissolved in CH2Cl2 and the solution washed with H2O. The organic layer was dried over MgSO4. Removal of the solvent yielded an oily residue, which was purified by column chromatography (CH2Cl2 to MeOH). After evaporation of the solvents benzyl N-(3-bromopropyl)carbamate was obtained as an orange oil (3.2 g, 86.4 %).
Rf (silica-gel, CHCl3) = 0.5. 1H-NMR (300 MHz, CDCl3, ppm) δH 7.32 (5H, m, Cbz), 5.15 (1H, br s, CBzNH-), 5.06 (2H, s, Cbz), 3.39 (2H, t), 3.30 (2H, q), 2.06 – 1.96 (2H, m). 13C-NMR (75.5 MHz, CDCl3, ppm) δc 156.4, 136.3, 128.4, 128.0, 127.9, 66.6, 39.2, 32.3, 30.6.
Benzyl (3-bromopropyl)carbamate Preparation Products And Raw materials
Raw materials
Preparation Products
Benzyl (3-bromopropyl)carbamate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5658 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Jiangsu Yaoheng Pharmaceutical Technology Co., Ltd. | 13524761129 | 2183470029@qq.com | China | 864 | 58 |
| EVERGREEN BIO-PHARM CO., LTD | 13522905323 | sales@hxybio.com | China | 339 | 58 |
| Henan Shengxiang Pharmatech LTD | 15515658315 | 3777161761@qq.com | China | 191 | 58 |
| Adamas Reagent, Ltd. | 400-6009262 16621234537 | zhangsn@titansci.com | China | 14113 | 59 |
39945-54-5(Benzyl (3-bromopropyl)carbamate)Related Search:
1of3