8-methylquinazoline-2,4(1H,3H)-dione
- CAS No.
- 67449-23-4
- Chemical Name:
- 8-methylquinazoline-2,4(1H,3H)-dione
- Synonyms
- 8-methylquinazoline-2,4-diol;2,4-Dihydroxy-8-methylquinazoline;8-methyl-1H-quinazoline-2,4-dione;8-methylquinazoline-2,4(1H,3H)-dione;2,4(1H,3H)-Quinazolinedione, 8-methyl-;8-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline;8-Methyl-1,2,3,4-tetrahydroquinazoline-2,4-dione
- CBNumber:
- CB91560405
- Molecular Formula:
- C9H8N2O2
- Molecular Weight:
- 176.17
- MDL Number:
- MFCD02167411
- MOL File:
- 67449-23-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 8-methylquinazoline-2,4-diol | CS-W001030 | 1g | $89 |
| 8-Methyl-1,2,3,4-tetrahydroquinazoline-2,4-dione | 4H48-1-MW | 1g | $199 |
| 8-methylquinazoline-2,4-diol | CS-W001030 | 5g | $277 |
| 8-methylquinazoline-2,4-diol | CS-W001030 | 10g | $472 |
| 8-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE 95.00% | CHM0101832 | 5MG | $498.49 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933599590 |
8-methylquinazoline-2,4(1H,3H)-dione price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-W001030 | 8-methylquinazoline-2,4-diol | 67449-23-4 | 1g | $89 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H48-1-MW | 8-Methyl-1,2,3,4-tetrahydroquinazoline-2,4-dione | 67449-23-4 | 1g | $199 | 2021-12-16 | Buy |
| ChemScene | CS-W001030 | 8-methylquinazoline-2,4-diol | 67449-23-4 | 5g | $277 | 2021-12-16 | Buy |
| ChemScene | CS-W001030 | 8-methylquinazoline-2,4-diol | 67449-23-4 | 10g | $472 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0101832 | 8-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE 95.00% | 67449-23-4 | 5MG | $498.49 | 2021-12-16 | Buy |
8-methylquinazoline-2,4(1H,3H)-dione Chemical Properties,Uses,Production
Synthesis
4389-45-1
57-13-6
67449-23-4
GENERAL METHOD: 2-Amino-3-methylbenzoic acid (5.0 g, 33.1 mmol) was mixed with urea (20 g) and the reaction was stirred at 160°C for 6 hours. Upon completion of the reaction, the reaction mixture was cooled to 100 °C and an equal volume of water was slowly added with continuous stirring for 5 min. Subsequently, the precipitate formed was collected by filtration and washed with cold water to obtain a solid filter cake. This filter cake was suspended in 0.5 N NaOH aqueous solution, heated to boiling and held for 5 minutes, then cooled to room temperature. The pH of the suspension was adjusted to 2 with concentrated hydrochloric acid and the quinazoline dione product was collected by filtration. The product was washed with a mixture of water: methanol (1:1) and dried under vacuum to give 4.50 g (25.5 mmol, 77% yield) of 2,4-dihydroxy-8-methylquinazoline solid. The 1H-NMR (CDCl3) data of the product were as follows: δ (ppm) 7.78-7.74 (m, 1H), 7.49-7.46 (m, 1H), 7.11-7.05 (m, 1H), 2.31 (s, 3H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 461 - 467
[2] Synthesis (Germany), 2016, vol. 48, # 8, p. 1226 - 1234
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 254 - 259
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5141 - 5156
[5] Patent: US2016/90374, 2016, A1. Location in patent: Paragraph 0170; 0171
8-methylquinazoline-2,4(1H,3H)-dione Preparation Products And Raw materials
8-methylquinazoline-2,4(1H,3H)-dione Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
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