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QUISQUALIC ACID

QUISQUALIC ACID
QUISQUALIC ACID
CAS No.
52809-07-1
Chemical Name:
QUISQUALIC ACID
Synonyms
QUISQUALATE;QUISQUALIC ACID;L-QUISQUALIC ACID;(+)-QUISQUALIC ACID;L(+)-QUISQUALIC ACID;3-(3,5-DIOXO-1,2,4-OXADIAZOLIDIN-2-YL)-L-ALANINE;β-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)-l-alanine;BETA-(3,5-DIOXO-1,2,4-OXADIZOLIDIN-2-YL)-L-ALANINE;L-(+)-a-Amino-3,5-Dioxo-1,2,4-oxadiazolidine-2-pro;BETA-[3,5-DIOXO-1,2,4-OXADIAZOLIDIN-2-YL]-L-ALANINE
CBNumber:
CB9198500
Molecular Formula:
C5H7N3O5
Formula Weight:
189.13
MOL File:
52809-07-1.mol

QUISQUALIC ACID Properties

Melting point:
185-187°C dec.
alpha 
D20 +17.0° (c = 2.0 in 6M HCl)
Boiling point:
324.36°C (rough estimate)
Density 
1.6649 (rough estimate)
refractive index 
1.6190 (estimate)
storage temp. 
2-8°C
solubility 
NH4OH 1 M: 20 mg/mL, clear, colorless
form 
powder
color 
white to off-white
Water Solubility 
Soluble in ethanol, water. Insoluble in organic solvents.
Merck 
13,8177
BRN 
1078734
Stability:
Stable. Incompatible with strong oxidizing agents.
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  26-36
WGK Germany  3
10
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P321 Specific treatment (see … on this label).
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

QUISQUALIC ACID price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Q2128 Quisqualic acid powder 52809-07-1 1mg $78.3 2018-11-13 Buy
Sigma-Aldrich Q2128 Quisqualic acid powder 52809-07-1 5mg $266 2018-11-13 Buy
Alfa Aesar J61591 (+)-Quisqualic acid, 99+% 52809-07-1 10mg $396 2018-11-13 Buy
Alfa Aesar J61591 (+)-Quisqualic acid, 99+% 52809-07-1 5mg $212 2018-11-13 Buy
Cayman Chemical 20211 L-Quisqualic Acid ≥99% 52809-07-1 1mg $44 2018-11-19 Buy

QUISQUALIC ACID Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

An amino acid that is able to function as an agonist at multiple excitatory amino acid receptor substrates in the central nervous system. It also has high affinity for the kainate, AMPA and the metabotropic receptors. Inhibits the Ca2+/Cl-dependent glutamic acid uptake system in brain synaptic plasma membrane preparations.

Biological Activity

Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect). Also available as part of the Group I mGlu Receptor Tocriset™ .

Purification Methods

It has been purified by ion-exchange chromatography on Dowex 50W (x 8, H+ form); the desired fractions are lyophilised and recrystallised from H2O/EtOH. It has IR (KBr) : 3400-2750br, 1830s, 1775s, 1745s and 1605s cm-1;maxand 1H NMR (NaOD/D2O, pH 13) : 3.55-3.57 (1H m, X of ABX, H-2), 3.72-3.85 (2H, AB of ABX, H-3), 1 3C NMR (D2O) : 50.1t, 53.4d, 154.8s, 159.7s and 171.3s. [Baldwin et al. J Chem Soc, Chem Commun 256 1985.] It is a quasiqualate receptor agonist [Joels et al. Proc Natl Acad Sci USA 86 3404 1989].

QUISQUALIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products


QUISQUALIC ACID Suppliers

Global( 57)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Nanjing Jie Bai Biotechnology Co. Ltd. 13338606537
+86-25-57010870 njyumao@163.com China 32 58
Nanjing Natural selection Biotechnology Co., Ltd. 025-57027729 15850702895
025-57027729 15850702895@163.com China 53 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15940 69
Ascent Scientific 4401179829988
4402030 700 369 customerservice@ascentscientific.co.uk United Kingdom 282 60
Nanjing Chemlin Chemical Co., Ltd 025-83697070
+86-25-83453306 sales@chemlin.com.cn China 20001 64
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32520 50
Syntechem Co.,Ltd Please Email
E-Mail Inquiry info@syntechem.com China 13092 57
NCE Biomedical Co.,Ltd. 4000-027-021 |24 hour enquiry :+86-13986109188 |English:+86-15623472865 |Japanese:+81-08033611988
+86-27-87599188 sales@ncebiomed.com China 1500 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 25127 65

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