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Hydroxyurea

Drugs and clinical application Dosage Adverse reactions, contraindications and the influence of drugs Chemical Properties Uses Production method
Hydroxyurea
Hydroxyurea structure
CAS No.
127-07-1
Chemical Name:
Hydroxyurea
Synonyms
hu;NHY;Oxyure;hidrix;hydrea;hydura;sq1089;DROXIA;Siklos;hydreia
CBNumber:
CB8249322
Molecular Formula:
CH4N2O2
Formula Weight:
76.05
MOL File:
127-07-1.mol

Hydroxyurea Properties

Melting point:
135-140 °C
Boiling point:
136.04°C (rough estimate)
refractive index 
1.4840 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
white
Water Solubility 
soluble
Merck 
14,4848
BRN 
1741548
CAS DataBase Reference
127-07-1(CAS DataBase Reference)
EPA Substance Registry System
Urea, hydroxy-(127-07-1)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H340-H361-H360
Precautionary statements  P501a-P201-P280-P308+P313-P281-P202-P405-P501
Hazard Codes  T,Xn
Risk Statements  46-63-61-40
Safety Statements  53-36/37-45-36-22
RIDADR  2811
WGK Germany  3
RTECS  YT4900000
Hazard Note  Toxic
HazardClass  6.1
PackingGroup  III
HS Code  29242100

Hydroxyurea price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 400046 Hydroxyurea 127-07-1 5gm $96.8 2018-11-20 Buy
Sigma-Aldrich 1332000 Hydroxyurea United States Pharmacopeia (USP) Reference Standard 127-07-1 200mg $348 2018-11-13 Buy
TCI Chemical H0310 Hydroxyurea >97.0%(N) 127-07-1 5g $87 2018-11-22 Buy
TCI Chemical H0310 Hydroxyurea >97.0%(N) 127-07-1 25g $249 2018-11-22 Buy
Alfa Aesar A10831 Hydroxyurea, 98% 127-07-1 1g $21.7 2018-11-13 Buy

Hydroxyurea Chemical Properties,Uses,Production

Drugs and clinical application

Hydroxyurea is a kind of anti-cancer drug for the treatment of chronic myeloid leukemia. At as early as the 1920s, it had been observed that hydroxyurea can cause the rabbits to produce megaloblastic cell similar as pernicious anemia and can inhibit leukocyte generation. In 1963 it had been found of its inhibitory effect on murine leukemia L1210. Hydroxyurea can induce bacteria to produce a toxic molecule itself to achieve the purpose of killing bacteria.
Hydroxy urea is a kind of nucleoside diphosphate reductase inhibitor and can inhibit the reduction from nucleotide to deoxynucleotide, interfering with the biosynthesis of purine and pyrimidine bases and selectively blocking the DNA synthesis. It can also cause partial inhibition of the conversion of ribonucleotides into deoxyribonucleotides. However, it has no blocking effect on RNA and protein synthesis. Hydroxyurea belongs to cycle specific drugs and is sensitive to S phase cell and can induce the hematologic remission of chronic myeloid leukemia. Compared with an alkylating agent busulfan and melphalan, it causes low incidence of secondary leukemia. The myelosuppressive effects of hydroxyurea will last for several days to several weeks which is easier to control compared with the alkylating agent. Clinically hydroxyurea is suitable or the treatment of chronic myeloid leukemia, acute lymphocytic and acute non-lymphocytic leukemia accompanied with high cell count, idiopathic thrombocythemia, polycythemia vera, prevention of retinoic acid syndrome in acute myeloid leukemia and treatment of sickle cell anemia with frequent episodes of pain. In addition, hydroxyurea have a certain effect on the treatment of head and neck cancer, recurrent metastatic ovarian cancer, renal cancer and so on.

Dosage

Adult usual dose:
1. chronic myeloid leukemia, usually the starting dose is daily 20~30mg/kg body weight, take 1 times or 2 times through oral administration; when white cells counts decreases to 10 × 109/L or less, reduce the dose to about 20mg/kg body weight daily with maintained oral administration or changed to oral intermittent administration.
2 for the treatment of head and neck cancer and ovarian cancer; the dose should be 60~80mg/kg body weight each time, or ​​2000~3000mg/m2 (body surface area) with oral administration once every three days. Administrate it alone or in combination with radiotherapy.
This information is edited by Xiongfeng Dai from Chemicalbook.

Adverse reactions, contraindications and the influence of drugs

Myelosuppression was dose-limiting toxicity. Hydroxyurea may cause neutropenia and thrombocytopenia which will disappear at 1 to 2 weeks after discontinuation of the drug; sometimes there may be gastrointestinal reactions, rash, and difficulty in urinating, renal tubular injury as well as testicular atrophy and teratogenesis; there are occasional cases of symptoms of central nervous system and hair loss. It has been also reported that it can cause drug-induced fever which is reproducible under repeated administration. Patients who have allergies, platelets being less than 50 × 109/L, chickenpox, shingles and various kinds of serious infections should be disabled. Pregnant and lactated women should also be disabled. Hydroxyurea can reduce the extent of 5-FU’s being converted into the active metabolite therefore it should be cautious when being taken together. When using hydroxyurea, we should be cautious if need to administrate barbiturates, antipsychotics and anesthetics; when hydroxyurea is combined with allopurinol, colchicine, probenecid for the treatment of gout, the dose of the above drugs should be adjusted. Avoid viral vaccination during treatment. The patients can only be subject to vaccination after discontinuing the drug for three months to one year. Upon taking hydroxyurea sheet, you should appropriately increase the fluid intake amount to increase the amount of urine and excretion of uric acid. The patients should also be subject to regular monitoring of white blood cells, platelets, blood urea nitrogen, uric acid level and inosine concentrations.

Chemical Properties

It appears as white needle-like crystals with the melting point being 70-72 ℃ (decomposition) or 141 ℃ (decomposition). It is easily soluble in hot water and ethanol, slightly soluble in cold ethanol, insoluble in ether, benzene. It is unstable when coming across water or heat. It is odorless and tasteless.

Uses

It belongs to anti-metabolic anti-cancer drugs with its major role in the proliferation of cells in G1 and S phase. It also had delayed effect on G1/S interface. It is a cell-specific drug.
It can be applied to biochemical studies.
Through the formation of free nitric oxide, it binds to the tyrosine of the enzyme active site, leaving the nucleoside reductase inactivated. This hampers the synthesis of deoxynucleotide. It is clinically used for the treatment of chronic myelogenous leukemia as well as being used to treat metastatic ovarian cancer, head and neck primary squamous cell carcinoma and intractable psoriasis. The good belongs to anticancer drugs.

Production method

It is produced through the reaction between ethyl carbamate and hydroxylamine hydrochloride. The sodium hydroxide solution was cooled to 20-25 ℃. Add alternately under stirring of urethane and hydroxylamine hydrochloride and react at 25-28 ℃ for 16h. Use hydrochloric acid to neutralize to a pH of 6.5-7, control the temperature be not exceeding 25 ℃. Then apply concentration under reduced pressure, filtered hot and the filtrate was cooled to below 0 ℃ to precipitate our the crystal, filter, wash crystal with ice water, and dry to give crude hydroxyurea with the yield of about 65%. After refining, we can obtain pharmaceutical grade hydroxyurea.

Chemical Properties

Off-White Crystalline Solid

Uses

An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.

Uses

antineoplastic, inhibits ribonucleoside diphosphate reductase

Indications

Hydroxyurea (Hydrea) inhibits the enzyme ribonucleotide reductase and thus depletes intracellular pools of deoxyribonucleotides, resulting in a specific impairment of DNA synthesis. The drug therefore is an Sphase specific agent whose action results in an accumulation of cells in the late G1- and early S-phases of the cell cycle.

General Description

Odorless or almost odorless white to off-white crystalline solid. Tasteless.

General Description

HONH-CO-NH2. The drug is available in a 500-mg capsulefor oral use. Hydroxyurea is often considered an antimetabolitedrug, and it is used to treat myelogenousleukemia, ovarian cancer, and essential thrombocytosis. Themechanism of action of hydroxyurea involves inhibition ofDNA biosynthesis by inhibition of the enzyme ribonucleotidereductase). Resistance can occur viaincreased expression of ribonucleotide reductase. The oralbioavailability is quite high approaching 100% and the drugis distributed to all tissues. Hydroxyurea readily enters theCNS and distributes to human breast milk. A major portionof the total dose is excreted unchanged in the urine. Thedrug has been shown to increase the toxicity of 5-FU, andhydroxyurea may increase the effectiveness of some antimetaboliteHIV drugs. The toxicity profile includes myelosuppression,leucopenia, nausea, vomiting, pruritus hyperpigmentation,headache, drowsiness, and confusion.

Air & Water Reactions

Water soluble.

Reactivity Profile

An amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

Flash point data for Hydroxyurea are not available; however, Hydroxyurea is probably combustible.

Mechanism of action

Hydroxyurea is rapidly absorbed after oral administration, with peak plasma levels achieved approximately 1 to 2 hours after drug administration; its elimination half-life is 2 to 3 hours. The primary route of excretion is renal, with 30 to 40% of a dose excreted unchanged.

Clinical Use

Hydroxyurea is used for the rapid lowering of blood granulocyte counts in patients with chronic granulocytic leukemia. The drug also can be used as maintenance therapy for patients with the disease who have become resistant to busulfan. Only a small percentage of patients with other malignancies have had even brief remissions induced by hydroxyurea administration.

Side effects

Hematological toxicity, with white blood cells affected more than platelets, may occur. Megaloblastosis of the bone marrow also may be observed. Recovery is rapid, generally within 10 to 14 days after discontinuation of the drug. Some skin reactions, including hyperpigmentation and hyperkeratosis, have been reported with chronic treatment.

Veterinary Drugs and Treatments

Hydroxyurea may be useful in the treatment of polycythemia vera, mastocytomas, and leukemias in dogs and cats. It is often used to treat dogs with chronic myelogenous leukemia no longer responsive to busulfan. Hydroxyurea, potentially, may be of benefit in the treatment of feline hypereosinophilic syndrome and in the adjunctive treatment of canine meningiomas. It can also be used in dogs for the adjunctive medical treatment (to reduce hematocrit) of right to left shunting patent ductus arteriosis or tetralogy of Fallot.

Purification Methods

Recrystallise hydroxyurea from absolute EtOH (10g in 150mL). Note that the rate of solution in boiling EtOH is slow (15-30minutes). It should be stored in a cool dry place, but some decomposition could occur after several weeks. [Deghenghi Org Synth Coll Vol V 645 1973.] It is very soluble in H2O and can be crystallised from Et2O. [Kfod Acta Chem Scand 10 256 1956, Beilstein 3 IV 170.]

Hydroxyurea Preparation Products And Raw materials

Raw materials

Preparation Products


Hydroxyurea Suppliers

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View Lastest Price from Hydroxyurea manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-08-27 Hydroxyurea Hydroxycarbamide
127-07-1
US $0.00-0.00 / KG 1g 99.0% 500kg/month Beijing Yibai Biotechnology Co., Ltd
2019-07-04 Hydroxyurea
127-07-1
US $1.00 / KG 1KG 98% 1kg,5kg,100kg career henan chemical co

Hydroxyurea Spectrum


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