YM155
- CAS No.
- 781661-94-7
- Chemical Name:
- YM155
- Synonyms
- M155;YM155;CS-35;YM155, >=98%;Sepantronium;YM-155;YM 155;YM155 USP/EP/BP;SepantroniuM broMide;Survivin Inhibitor YM155;YM155 (SepantroniuM BroMide)
- CBNumber:
- CB92506237
- Molecular Formula:
- C20H19BrN4O3
- Molecular Weight:
- 443.29386
- MDL Number:
- MFCD11983133
- MOL File:
- 781661-94-7.mol
| Melting point | >180°C (dec.) |
|---|---|
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | solid |
| color | Tan to yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| FDA UNII | 7H5Q4J1CM5 |
| NCI Drug Dictionary | sepantronium bromide |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 29339900 |
YM155 price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 574662 | Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem The Survivin Inhibitor, YM155, also referenced under CAS 781661-94-7, controls the biological activity of Survivin. | 781661-94-7 | 10MG | $155 | 2022-05-15 | Buy |
| Cayman Chemical | 11490 | YM-155 ≥98% | 781661-94-7 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 11490 | YM-155 ≥98% | 781661-94-7 | 5mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 11490 | YM-155 ≥98% | 781661-94-7 | 10mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 11490 | YM-155 ≥98% | 781661-94-7 | 25mg | $257 | 2024-03-01 | Buy |
YM155 Chemical Properties,Uses,Production
Description
YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1?Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2?Induces DNA damage.3?YM-155 induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4
Uses
YM155 is a potent IAP (inhibitor of apoptosis proteins) inhibitor for survivin with IC50 of 0.54 nM.
Uses
YM155 is a novel small-molecule survivin suppressant that suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC. cell lines. Potent Survivin Inhibitor.
Definition
ChEBI: Sepantronium bromide is an organic bromide salt consisting of sepantronium cations and bromide anions. It has been found to selectively inhibit survivin (BIRC5) gene promoter activity and to down-regulate survivin in vitro, so leading to induction of apoptosis. It has a role as an antineoplastic agent, a survivin suppressant and an apoptosis inducer. It contains a sepantronium.
target
Survivin
storage
Store at -20°C
References
1) Nakahara?et al. (2007),?YM155, a novel small-molecule surviving suppressant, induces regression of established human hormone-refractory prostate tumor xenografts; Cancer Res.?67?8014 2) Okamoto?et al. (2012),?Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin; Mol.Cancer Ther.?11?204 3) Glaros?et al. (2012),?The ‘survivin suppressants’ NSC 80467 and YM 155 induce a DNA damage response; Cancer Chemother. Pharmacol.?70?207 4) Wang?et al. (2014),?Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma; Apoptosis?19?748
YM155 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28200 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hunan Jibang Biological Technology Co., LTD | +8613776644403 | sales02@kingboomtech.com | China | 1806 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
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