NSC-348884
- CAS No.
- 81624-55-7
- Chemical Name:
- NSC-348884
- Synonyms
- CS-2168;NSC-348884;NSC 348884/NSC348884;NSC348884;NSC-348884;NSC 348884;N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine;N1,N1,N2,N2-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine;1,2-Ethanediamine, N1,N1,N2,N2-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-;1,2-EthanediaMine, N,N,N',N'-tetrakis[(5-Methyl-1H-benziMidazol-2-yl)Methyl]- (9CI);lymphoma,cancer,inhibit,SKOV3,MOSEC/Luc cell,NSC-348884,NSC 348884,LNCaP,doxorubicin,NSC348884,Inhibitor,ES2,small molecular,p53,Apoptosis
- CBNumber:
- CB92582798
- Molecular Formula:
- C38H40N10
- Molecular Weight:
- 636.79
- MDL Number:
- MFCD12546137
- MOL File:
- 81624-55-7.mol
NSC-348884 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16716 | NSC 348884 ≥98% | 81624-55-7 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 16716 | NSC 348884 ≥98% | 81624-55-7 | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 16716 | NSC 348884 ≥98% | 81624-55-7 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 16716 | NSC 348884 ≥98% | 81624-55-7 | 25mg | $479 | 2024-03-01 | Buy |
| TRC | N900560 | NSC348884 | 81624-55-7 | 250mg | $250 | 2021-12-16 | Buy |
NSC-348884 Chemical Properties,Uses,Production
Uses
NSC348884 is a biochemical which inhibitss NPM oligomer formation, upregulates p53 and induces apoptosis.
Biological Activity
nsc348884 is a nucleophosmin inhibitor.nucleophosmin is identified as a multifunctional nucleolar phosphoprotein, which is dysregulated in human malignancies resulting in anti-apoptosis and differentiation inhibition.
in vitro
nsc348884, which was identified as a putative nucleophosmin small molecular inhibitor, was found to be able to disrupt a hydrophobic pocket that was required for oligomerization, and nsc348884 could also inhibit the cell proliferation in distinct cancer cell lines and disrupt nucleophosmin oligomer formation. moreover, the treatment of several cancer cell types with nsc348884 could dose-dependently upregulate p53 and also induce apoptosis that correlated with h2ax phosphorylation, poly(adp-ribose) polymerase cleavage as well as annexin v. furthermore, nsc348884 could also synergize doxorubicin cytotoxicity on the viability of cancer cells [1].
in vivo
previous study showed that the in-vivo intravasation and invasion could be significantly inhibited after the injection of nsc348884 into the tumor-bearing mice. in addition, there was no significant difference in overall cell death that was observed by histology in the treated tumors with the 4-hour brief treatments, indicating that the inhibition seen was specific to migration [2].
IC 50
1.7-4.0 μm for tested cancer cell lines
References
[1] qi w,shakalya k,stejskal a,goldman a,beeck s,cooke l,mahadevan d. nsc348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. oncogene.2008 jul 10;27(30):4210-20.
[2] patsialou a,wang y,lin j,whitney k,goswami s,kenny pa,condeelis js. selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. breast cancer res.2012 oct 31;14(5):r139.
NSC-348884 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4647 | 58 |
View Lastest Price from NSC-348884 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | NSC-348884
81624-55-7
|
US $1.00 / g | 1g | 99% | 200kg | Career Henan Chemical Co |
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- NSC-348884
81624-55-7
- US $1.00 / g
- 99%
- Career Henan Chemical Co